Topical Therapies for Pruritus

Elmariah, Sarina B.; Lerner, Ethan A.

doi:10.1016/j.sder.2011.04.008

Cited by 80 publications

(70 citation statements)

References 77 publications

(82 reference statements)

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“…There was less symptom of burning and itching in the steroid group compared to the control group. This was somewhat expected as standard management of pruritus associated with inflammatory diseases include topical corticosteroids such as mometasone and betamethasone (46,47). Five of the trials had either mometasone or betamethasone as intervention.…”

Section: Discussionmentioning

confidence: 98%

Topical Management of Acute Radiation Dermatitis in Breast Cancer Patients: A Systematic Review and Meta-Analysis

Haruna

Lipsett

Marignol

2017

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(OR: 0.29; p<0.0001) and reducing the mean RD score p<0.00001 Radiation induces damage to the skin, activating inflammatory pathways and causing cytokines overproduction (1, 2). Radiation dermatitis is a common acute side-effect that occurs within hours to weeks after the start of radiotherapy (3, 4) and affects more than 87% of patients (2, 5). Radiation dermatitis can limit the therapeutic dose delivered to patients and can, sometimes, lead to a break in treatment, thus potentially compromising local control and survival outcome (1, 6). It can also have a considerable impact on patients' quality of life (7,8). Despite significant development in radiotherapy techniques, efficacious interventions in the prevention of acute skin reactions is still lacking and current evidence is unable to provide adequate guidelines for the management of this sideeffect (9, 10). Studies have examined numerous topical agents such as Aloe Vera, aqueous cream, Calendula, petrolatum and sulcrafate cream as a means to reducing the dehydrating effects of radiation dermatitis (6,11,12). However, the results in terms of managing radiation dermatitis and treatment related pain have not been clinically significant (13,14). Corticosteroids have anti-inflammatory properties and are known to down-regulate cytokine gene expression, making them ideal for managing radiation dermatitis (15-17). A systematic review by Bolderston et al. concluded that there is limited evidence to support or oppose the use of topical agents for the management of acute radiation dermatitis (18).Skin care advice given to breast cancer patients varies among institutions (19). No gold-standard for the appropriate management of this side-effect exists and in most cases the decision of care is left at the discretion of the health care professional rather than clinical evidence (20,21). Clinical advice is often given based on anecdotal evidence (22).The present systematic review and meta-analysis was conducted to assess the potential efficacy of corticosteroids in the management of RD and its impact on pain and quality of life in female breast cancer patients. However, the anticipated adverse effect associated with steroids is not evaluated and is beyond the scope of this review. We restricted our review to one site only due to radiotherapy dose variations used in different sites. Materials and MethodsSearch strategy for identification of studies. The electronic literature search was conducted up to and including March 2017. The search terms used were corticosteroid, radiation dermatitis, breast cancer, management, and prevention. The reference lists of potentially eligible studies were subsequently hand searched to identify 5343

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Section: Discussionmentioning

confidence: 98%

Topical Management of Acute Radiation Dermatitis in Breast Cancer Patients: A Systematic Review and Meta-Analysis

Haruna

Lipsett

Marignol

2017

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“…52 The management of pruritus must be based on the physiology of the underlying cause of the itch and must be individualized. 52 While all methods for preventing and treating itch might not be appropriate for the various itchy wounds, options which might be considered are discussed. Many of the treatment options available for managing itch are only appropriate for use once the wounds have healed.…”

Section: Management Of Wound Pruritusmentioning

confidence: 99%

“…42 Pramoxine and eutectic mixture of lidocaine and prilocaine have been used. 42,47,52,54 Antihistamines Sedating antihistamines including hydroxyzine, doxepin, and diphenhydramine have been used with mixed results. 47,52,54 Anticonvulsants Gabapentin may act by blocking postsynaptic calcium channels or inhibiting neurotransmitter synthesis.…”

Section: Anestheticsmentioning

confidence: 99%

“…34,42,52 Photochemotherapy and phototherapy (UVB, ultraviolet B radiation) have been effective in some cases. 34 …”

Section: Chemotherapymentioning

confidence: 99%

“…Wounds as the source or cause of localized itch pose a dilemma in terms of usual treatment for localized itch, which might include at first, moisturizers, emollients, antihistamine creams, and topical corticosteroids; then systemic therapies; and then combination topical and systemic therapy. 52,62 As more is known about itch physiology, advances in itch therapy can be made.…”

Section: Summary Regarding Management Of Wound Pruritusmentioning

confidence: 99%

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Wound pruritus: pathophysiology and management

Paul

2015

CWCMR

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Purpose: The objective of this article is to review literature on wound pruritus, with a focus on summarizing pathophysiology and management. Method: Literature related to the physiology of itch was reviewed. PubMed, MEDLINE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Embase were searched for all research studies written in English which include "wound" (injury/burn) and "pruritus" (itch) in the title or abstract. Articles were accepted if they involved wounds or acute burns. Literature related to options for management of wound pruritus was reviewed. Results: While all types of wounds can be the source of associated pruritus, most studies have been done concerning pruritus associated with burns. There are treatment options for pruritus which can be considered for management of wound pruritus. Conclusion: Further research is indicated to gain insights into the problem of wound pruritus. As more is learned about the physiology of wound pruritus, more effective management strategies can be developed and employed.

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Dermatologicals (D), 2. Antifungals (D01), Emollients and Protectives (D02), and Antipruritics (D04) for Dermatological Use

Kutscher¹

2020

Ullmann's Encyclopedia of Industrial Chemistry

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Topical Therapies for Pruritus

Cited by 80 publications

References 77 publications

Topical Management of Acute Radiation Dermatitis in Breast Cancer Patients: A Systematic Review and Meta-Analysis

Topical Management of Acute Radiation Dermatitis in Breast Cancer Patients: A Systematic Review and Meta-Analysis

Wound pruritus: pathophysiology and management

Dermatologicals (D), 2. Antifungals (D01), Emollients and Protectives (D02), and Antipruritics (D04) for Dermatological Use

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