The Antiperspirant Action of Topically Applied Anticholinergics*†

MacMillan, F.S. Kilmer; Reller, Herbert H.; Synder, Fred H.

doi:10.1038/jid.1964.167

Cited by 63 publications

(29 citation statements)

References 7 publications

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“…Relatively low efficacy, poor absorption, and cutaneous and systemic adverse effects [18,[66][67][68][69] Topical glycopyrrolate (0.5-4% cream, aqueous solution or pads) is primarily indicated for craniofacial HH [70,71] and various types of gustatory sweating (Frey syndrome, [72] diabetic, [73,74] and compensatory [75] ) anesthetics (e.g. lidocaine [lignocaine], prilocaine)…”

Section: Diagnostic Approachmentioning

confidence: 99%

Botulinum Toxin for Hyperhidrosis

Grunfeld

Murray

Solish

2009

American Journal of Clinical Dermatology

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Primary focal hyperhidrosis is a disorder of idiopathic excessive sweating that typically affects the axillae, palms, soles, and face. The disorder, which affects up to 2.8% of the US population, is associated with considerable physical, psychosocial, and occupational impairments. Current therapeutic strategies include topical aluminum salts, tap-water iontophoresis, oral anticholinergic agents, local surgical approaches, and sympathectomies. These treatments, however, have been limited by a relatively high incidence of adverse effects and complications. Non-surgical treatment complications are typically transient, whereas those of surgical therapies may be permanent and significant. Recently, considerable evidence suggests that botulinum toxin type A (BTX-A) injections into hyperhidrotic areas can considerably reduce focal sweating in multiple areas without major adverse effects. BTX-A has therefore shown promise as a potential replacement for more invasive treatments after topical aluminum salts have failed. This article reviews the epidemiology, diagnosis, and management of primary focal hyperhidrosis, with an emphasis on recent research evidence supporting the use of BTX-A injections for this indication.

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Section: Diagnostic Approachmentioning

confidence: 99%

Botulinum Toxin for Hyperhidrosis

Grunfeld

Murray

Solish

2009

American Journal of Clinical Dermatology

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“…A tissue counterpart of m 4 has been found in the peripheral lung strip of the rabbit (27,28); however, the physiological function of M 4 has not been elucidated yet. The tissue and functional counterparts of m 5 have not been discovered yet.…”

Section: Introductionmentioning

confidence: 99%

“…Muscarinic receptor antagonists have also been used as mydriatic/cycloplegic agents (2-4) and as experimental antiperspirants (5)(6)(7). Because of the broad range of anticholinergic effects, treatment with belladonna alkaloids directed to a certain organ system almost always induces undesirable effects in other organ systems (4).…”

Section: Introductionmentioning

confidence: 99%

Receptor binding studies of soft anticholinergic agents

et al. 2001

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“…Most dermatologists however, find their use uniformly disappointing. More recently topical scopolamine esters have been used to suppress axillary sweating (MacMillan, Reller & Snyder, 1964;Stoughton et al, 1964). Surgical management of axillary hyperhidrosis includes cervico-thoracic sympathectomy, with the removal of the 4th and 5th thoracic ganglia (Mac-Gregor, 1955;DeTakats, 1957) and a local surgical technique involving dissection of the glandular layer of the axilla, described by Skoog & Thyresson, 1962. Apart from the greater surgical hazards associated with sympathectomy over this simple pro- cedure, is the occasional disadvantage of the compensatory thermal hyperhidrosis, principally of the trunk, that may ensue (Shelley & Florence, 1960).…”

Section: Discussionmentioning

confidence: 99%

Axillary skin excision as a treatment for axillary hyperhidrosis

Weaver

1970

Postgraduate Medical Journal

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Treatment10% iodine in starch powder was applied to both axillae on a small cotton wool pad, after initially washing and drying the axillae with dry gauze. After 2 or 3 min, sweat from the glands in the central portion of the axillae had turned the starch iodine powder dark blue. The stained zone measured 4 x 6 cm. Under general anaesthesia, bilateral elliptical incisions were made in the axillae and placed transversely in the line of the skin crease. They were both 7 cm long and 3 cm wide at the centre. The skin edges were undercut by 1 cm on either side removing subcutaneous glandular tissue. Warm wet swabs were placed in the wounds and pressure applied for 5 min. Any remaining bleeding points were diathermied. After haemostasis the skin edges were apposed with interrupted silk mattress sutures and a light pressure dressing applied for the first 24 hr. The patient was then discharged from hospital and returned 8 days later for removal of his sutures (Fig. 1.). Wound healing was satisfactory and the operation caused minimal discomfort. The patient was delighted with the result and is symptom-free after a period of 9 months.Case 2. C.D.Male, aged 20, a university student, was referred from the Department of Dermatology at the Westminster Hospital following the demonstrated success of our first patient. This patient was an anxious, rather highly strung young man with generalized hyperhidrosis which was much worse in his axillae on 9 May 2018 by guest. Protected by copyright.

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The Antiperspirant Action of Topically Applied Anticholinergics*†

Cited by 63 publications

References 7 publications

Botulinum Toxin for Hyperhidrosis

Botulinum Toxin for Hyperhidrosis

Receptor binding studies of soft anticholinergic agents

Axillary skin excision as a treatment for axillary hyperhidrosis

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