Botulinum Toxin for Hyperhidrosis

Grunfeld, Alexander; Murray, Christian; Solish, Nowell

doi:10.2165/00128071-200910020-00002

Cited by 80 publications

(90 citation statements)

References 179 publications

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“…Sabe-se que a toxina botulí-nica tem efeito inibitório na secreção de glândulas exógenas, sendo utilizada para o tratamento de lacrimejamento reflexo por regeneração aberrante de paralisia de nervo facial (síndro-me das lágrimas de crocodilo) (15) e na hiperhidrose (16)(17) . É possível que a toxina aplicada na região pré-septal da pálpebra possa difundir para as glândulas lacrimais acessórias e principal causando diminuição da secreção aquosa e justificando a redução nos valores de Schirmer basal.…”

Section: Discussionunclassified

Influência da toxina botulínica tipo A na função lacrimal de pacientes com distonias faciais

Oliveira¹,

Oliveira²,

Cariello³

et al. 2010

Arq. Bras. Oftalmol.

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Section: Discussionunclassified

Influência da toxina botulínica tipo A na função lacrimal de pacientes com distonias faciais

Oliveira¹,

Oliveira²,

Cariello³

et al. 2010

Arq. Bras. Oftalmol.

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“…1,4 Normally, percutaneous penetration of drugs is restricted by the epidermis. Iontophoresis and phonophoresis are noninvasive methods of administering molecules through the skin, facilitating their penetration through hair follicles or sweat ducts.…”

Section: Comunicationmentioning

confidence: 99%

“…8 Intradermal infiltrations of BTX (types A and B) are effective options; however, they are limited by their cost and by the local discomfort, and may result in transitory alterations to the fine movements of the hands. 4,7 T2-T3 thoracic sympathectomy is an alternative solution for palmar hyperhidrosis; however, it is asso- …”

Section: Comunicationmentioning

confidence: 99%

Tratamento da hiperidrose palmar com onabotulinumtoxinA veiculada por iontoforese ou fonoforese: relato de casos

Andrade

Flores²,

Uscello³

et al. 2011

An. Bras. Dermatol.

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Hiperidrose palmar idiopática é doença frequente, que tem grande impacto na qualidade de vida dos pacientes, e seu tratamento definitivo (simpatectomia) associa-se a risco cirúrgico e efeitos adversos. Fármacos, como onabotulinumtoxinA, podem ser veiculados percutaneamente por iontoforese ou fonoforese e contribuir no tratamento da hiperidrose. Os autores apresentam quatro casos em que houve melhora objetiva e subjetiva da sudorese após dez sessões consecutivas de iontoforese ou fonoforese, sem evidências de efeitos adversos. Os resultados clínicos mantiveram-se por 16 semanas de observação após a interrupção do tratamento. Técnicas de veiculação percutânea de medicamentos devem ser percebidas como opções nos tratamentos dermatológicos.

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“…Various methods for reducing excessive sweating include: special diets (without coffee, tea, coca-cola, chocolate), diverse antiperspirants, such as over-the counter ointments/tinctures, topical aluminium chloride, medicines, drugs (oral anticholinergics), tap water ionophoresis (9), intradermal injections of botulinum toxin type A (botox) (10,11), but only surgical treatment has shown the best long-term results (12)(13)(14).…”

Section: Surgical Techniquementioning

confidence: 99%

Videothoracoscopic sympathectomy - a standard treatment for primary hyperhidrosis at the Clinic of Thoracic Surgery in Sremska Kamenica / Videotorakoskopska simpatektomija – standarna hirurška metoda za lečenje primarne hiperhidroze na Klinici za grudnu hirurgiju u Sremskoj Kamenici

Kuhajda¹,

Milos²,

Đurić³

et al. 2010

Serbian Journal of Dermatology and Venerology

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Primary hyperhidrosis affects approximately 3% of the world's population, particularly young female adults. It is defined as excessive, profuse sweating of the palms, soles, armpits and face. Conservative treament includes diverse modalities, however, surgical treatment has shown the best long-term results. The objective of this study was to assess some disease-specific epidemiological characteristics in a pre-selected group of patients seeking surgical therapy, as well as outcomes of thoracoscopic sympathectomy. The severity and impact of hypehidrosis was assessed, using Hyperhidrosis Disease Severity Scale (HDSS: patients rate the serverity of symptoms on a scale from 1 to 4). Thoracoscopic sympathectomy was performed using a double lumen endotracheal tube, via bilateral 5 mm dual port videothoracoscopic camera 0°, and an endoscopic ultrasound activated harmonic scalpel. The sympathetic chain was resected on both sides at the level of the second and the third thoracic ganglion (T2 and T3), using an ultrasound knife. The extirpated chain was also at the level T3-T4 and sent for ex tempore analysis. There were 162 patients undergoing thoracoscopic sympathectomy: 39.51% were males and 60.49% females; at presentation their mean age (± SD) was 30.5 (±8.3), range 16 -58 years. Axillary hyperhidrosis occurs later than palmar-axillary-plantar (p<0.05). A total of 35.18% of the evaluated patients were able to name at least one member of their families who also suffered from hyperhidrosis. The most commonly affected area was palmar-axillary-plantar (30.25%). Fifty patients (30.86%) received conservative therapy before surgery. The most commonly used conservative therapy modalities included different kinds of ointments/tinctures (11.73%), botox (8.02%) and iontophoresis (2.47%). Prior to surgery, 91.36% of patients reported severe sweating (HDSS score 3 or 4). The highest mean score was given for a combination of facial-palmar-axillaryplantar hyperhidrosis (3.80±0.24). All surgeries were successfully performed, with no complications, or perioperative morbidity. The mean hospital stay was 1.28±0.68 days long. After surgery, 93.21% of patients reported mild or moderate hyperhidrosis (HDSS score 1 or 2). Compensatory sweating (lower part of the back, and abdomen) was reported by 34.57% of patients after the surgery. All patients had a 6-months long follow-up: a significant improvement in quality of life was reported by 84.56% of patients (Yates corrected c 2 (1) = 228.42; p=0.0000)); due to compensatory sweating, only 4.94% and 1.85% of patients reported bad and very bad quality of life, respectively. In conclusion, nowadays videothoracoscopic sympathectomy is a standard treatment for primary hyperhidrosis with a high success rate. T5, and to lower limbs at T2 and T7. Videothoracoscopic sympathectomy -a standard treatment for primary hyperhidrosis at the Clinic of Thoracic Surgery in Sremska KamenicaExcessive sweating or hyperhidrosis affects approximately 3% of the world population (1, 2), predominantly young femal...

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Botulinum Toxin for Hyperhidrosis

Cited by 80 publications

References 179 publications

Influência da toxina botulínica tipo A na função lacrimal de pacientes com distonias faciais

Influência da toxina botulínica tipo A na função lacrimal de pacientes com distonias faciais

Tratamento da hiperidrose palmar com onabotulinumtoxinA veiculada por iontoforese ou fonoforese: relato de casos

Videothoracoscopic sympathectomy - a standard treatment for primary hyperhidrosis at the Clinic of Thoracic Surgery in Sremska Kamenica / Videotorakoskopska simpatektomija – standarna hirurška metoda za lečenje primarne hiperhidroze na Klinici za grudnu hirurgiju u Sremskoj Kamenici

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