The antioxidant system in combined therapy of epilepsy with traditional anticonvulsants and an antioxidant ?-tocopherol

Tupeev, I. R.; Крыжановский, Г. Н.; Nikushkin, E. V.; Bordyukov, M. M.; Yuzefova, S. M.

doi:10.1007/bf00802834

Cited by 8 publications

(8 citation statements)

References 2 publications

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“…Only after one month of additional therapy, they reported greatly improved patients' general state, achieved namely through decreased epileptic seizure frequency, which was further supported by an observed increase in SOD activity and consequently significant improvement in EEG results. They concluded that using of α-tocopherol in the multiple-therapy approach to epilepsy treatment improved neuroprotective and antiepileptic effects [ 218 ].…”

Section: Studies Of Antioxidants Usage In Patients With Epilepsymentioning

confidence: 99%

Antioxidants as a Preventive Treatment for Epileptic Process: A Review of the Current Status

Martinc¹,

Grabnar²,

Vovk

2015

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Epilepsy is known as one of the most frequent neurological diseases, characterized by an enduring predisposition to generate epileptic seizures. Oxidative stress is believed to directly participate in pathways leading to neurodegeneration, which serves as the most important propagating factor, leading to the epileptic condition and cognitive decline. Moreover, there is also a growing body of evidence showing the disturbance of antioxidant system balance and consequently increased production of reactive species in patients with epilepsy. A meta-analysis, conducted in the present review confirms an association between epilepsy and increased lipid peroxidation. Furthermore, it was also shown that some of the antiepileptic drugs could potentially be responsible for additionally increased lipid peroxidation. Therefore, it is reasonable to propose that during the epileptic process neuroprotective treatment with antioxidants could lead to less sever structural damages, reduced epileptogenesis and milder cognitive deterioration. To evaluate this hypothesis studies investigating the neuroprotective therapeutic potential of various antioxidants in cells, animal seizure models and patients with epilepsy have been reviewed. Numerous beneficial effects of antioxidants on oxidative stress markers and in some cases also neuroprotective effects were observed in animal seizure models. However, despite these encouraging results, till now only a few antioxidants have been further applied to patients with epilepsy as an add-on therapy. Based on the several positive findings in animal models, a strong need for more carefully planned, randomized, double-blind, cross-over, placebo-controlled clinical trials for the evaluation of antioxidants efficacy in patients with epilepsy is warranted.

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Section: Studies Of Antioxidants Usage In Patients With Epilepsymentioning

confidence: 99%

Antioxidants as a Preventive Treatment for Epileptic Process: A Review of the Current Status

Martinc¹,

Grabnar²,

Vovk

2015

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“…The protective, anti-atheromatic effect of vitamins is based on their anti-oxidant and anti-inflammatory properties. Tupeev et al (1993) found a positive effect of prolonged vitamin E treatment (600 mg/day) in patients with generalized seizures: seizure frequency was reduced, EEG improved and anti-oxidant activity increased.…”

Section: Drug-resistant Epilepsy and Polytherapymentioning

confidence: 96%

Epilepsy Treatment and Nutritional Intervention

Majkowski¹

2014

Pharmacology and Nutritional Intervention in the Treatment of Disease

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“…Tupeev et al [119] found a positive effect of prolonged vitamin E treatment (600 mg/day) in patients with generalized seizures: seizure frequency was reduced, EEG improved, and antioxidant activity increased.…”

Section: Drug-resistant Epilepsy: Polytherapymentioning

confidence: 99%

Free Radicals and Antioxidants: Opportunities for Enhancing Treatment of Epilepsy with Personalized Medicine

Majkowski¹,

Westermarck²,

Atroshi³

2020

Personalized Medicine, in Relation to Redox State, Diet and Lifestyle

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Introduction: Epileptic seizures and antiepileptic drugs (AEDs) are a source of oxygen stress. Oxygen stress can have negative effects. These effects which can be prevented are largely unknown in clinical epileptology. Objective: The objective of the study is to discuss (a) homeostatic oxidant, antioxidant imbalance due to epileptic seizures and AEDs, (b) the protective factors that help prevent oxygen stress (OS), and personalized medicine based on pharmacogenomics and diet as therapeutic challenges in epilepsy. Discussion: Experimental models of epileptic seizures evoked by various means suggest that seizures can cause neuronal destruction. This is accompanied by an increased activity of free radicals and a reduction of total antioxidant capacity (in red blood cells, blood serum, and cerebrospinal fluid). A number of antioxidants have been found to attenuate the negative effects of OS and act neuroprotectively if they are administered prior to seizure occurrence: vitamins (C, E), trace elements (Se, Zn), melatonin, erdosteine, or natural herbal extracts. New AEDs (GBP, LEV, LTG, and TGB) cause no, or very little, OS as opposed to other drugs (CBZ, PHT, PB, VPA, TPM, or OXC), which have pronounced albeit heterogeneous and dose-dependent effects. It is suggested that AEDs should be administered together with free radical sweepers (vitamins, trace elements, electrolytes, melatonin) and other anti-oxidizing substances. Conclusions: (1) Epileptic seizures and AEDs cause OS. The effects vary greatly depending, among other things, on the daily drug dose. (2) The findings of research using a variety of seizure models are more unequivocal than the findings of research on patients with epilepsy. This suggests that the relations among seizures, AEDs, OS etiology, and OS consequences are complex. (3) Since existing AEDs cause OS, it is necessary to develop a new approach to AED treatment. (4) It is important to know the patient's specific characteristics, including previous history, lifestyle, age, gender, weight, diet, environment, etc. They can be valuable tools to improve the quality of life of a person suffering from epilepsy. This concept of managing the patient health is called targeted medicine or personalized medicine.

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The antioxidant system in combined therapy of epilepsy with traditional anticonvulsants and an antioxidant ?-tocopherol

Cited by 8 publications

References 2 publications

Antioxidants as a Preventive Treatment for Epileptic Process: A Review of the Current Status

Antioxidants as a Preventive Treatment for Epileptic Process: A Review of the Current Status

Epilepsy Treatment and Nutritional Intervention

Free Radicals and Antioxidants: Opportunities for Enhancing Treatment of Epilepsy with Personalized Medicine

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