Epilepsy Treatment and Nutritional Intervention

Majkowski, J

doi:10.5772/57484

Cited by 2 publications

(5 citation statements)

References 147 publications

(132 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, pretreatment with WCW 2 hours before systemic injection of KA produced a better protective effect than post-treatment (12,36, and 60 hours), especially in the CA3 region (Fig. 3).…”

Section: Discussionmentioning

confidence: 63%

“…8,12,14 Therefore, we evaluated whether the level of the seizures was related to the level of cell death in the hippocampus by evaluating the level of hippocampal cell death 3 days after the i.p. injection of KA.…”

Section: Discussionmentioning

confidence: 99%

“…), and WCW groups (WCW-only-treated group; saline, i.c.v.+WCW, p.o.). To examine the therapeutic time window of WCW for the KAinduced cell death in hippocampus, mice from KA+WCW group were randomly subdivided into the following groups (n = 6-7 per group): KA-treated and WCW-pretreated group (2 hours before KA injection) and post-treated groups (12,36, and 60 hours after KA injection).…”

Section: Experiments Groups To Evaluate Excitotoxic Cell Deathmentioning

confidence: 99%

“…Epilepsy also affects about 1% of the world population, and 30% of the epileptic patients are resistant to anticonvulsant drugs. 12 Moreover, anticonvulsant drugs only provide symptomatic treatment without influencing the course of the disease, and thus, alternative therapeutic approaches to attenuate epileptogenesis after a seizure are highly desirable.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Oriental Medicine Woohwangchungsimwon Attenuates Kainic Acid-Induced Seizures and Neuronal Cell Death in the Hippocampus

Choi

Jang

Kim

et al. 2016

Rejuvenation Research

View full text Add to dashboard Cite

Woohwangchungsimwon (WCW) is an oriental medicine that has been extensively prescribed in Asia to patients with apoplexy, high blood pressure, acute/chronic convulsion, and so on. However, the potential therapeutic value of WCW in treating the pathologic brain has not yet been fully investigated. In the present study, we evaluated whether WCW has beneficial effects on kainic acid (KA)-induced excitotoxicity. An intraperitoneal injection of KA (40 mg/kg) and an intracerebroventricular injection of KA (0.2 μg) produced typical seizure behavior and neuronal cell death in the CA1 and CA3 pyramidal layers of the hippocampus, respectively. However, the systemic administration of WCW significantly attenuated the seizure behavior and neuronal cell death. WCW was found to exert the best protective effect when it was administrated 2 hours before a KA injection. Moreover, this WCW-induced neuroprotection was accompanied by a reduction in microglia activation and tumor necrosis factor-alpha, interleukin (IL)-1β, IL-6, inducible nitric oxide synthase, and cyclooxyganase-2 in the hippocampus. These results suggest that WCW has therapeutic potential to suppress KA-induced pathogenesis in the brain by inhibiting inflammation.

show abstract

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Experiments Groups To Evaluate Excitotoxic Cell Deathmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Oriental Medicine Woohwangchungsimwon Attenuates Kainic Acid-Induced Seizures and Neuronal Cell Death in the Hippocampus

Choi

Jang

Kim

et al. 2016

Rejuvenation Research

View full text Add to dashboard Cite

show abstract

“…properties have been attributed to anti-stress, immune-modulating, anti-inflammatory, and antiaging effects [120].…”

Section: Drug-resistant Epilepsy: Polytherapymentioning

confidence: 99%

Free Radicals and Antioxidants: Opportunities for Enhancing Treatment of Epilepsy with Personalized Medicine

Majkowski¹,

Westermarck²,

Atroshi³

2020

Personalized Medicine, in Relation to Redox State, Diet and Lifestyle

Self Cite

View full text Add to dashboard Cite

Introduction: Epileptic seizures and antiepileptic drugs (AEDs) are a source of oxygen stress. Oxygen stress can have negative effects. These effects which can be prevented are largely unknown in clinical epileptology. Objective: The objective of the study is to discuss (a) homeostatic oxidant, antioxidant imbalance due to epileptic seizures and AEDs, (b) the protective factors that help prevent oxygen stress (OS), and personalized medicine based on pharmacogenomics and diet as therapeutic challenges in epilepsy. Discussion: Experimental models of epileptic seizures evoked by various means suggest that seizures can cause neuronal destruction. This is accompanied by an increased activity of free radicals and a reduction of total antioxidant capacity (in red blood cells, blood serum, and cerebrospinal fluid). A number of antioxidants have been found to attenuate the negative effects of OS and act neuroprotectively if they are administered prior to seizure occurrence: vitamins (C, E), trace elements (Se, Zn), melatonin, erdosteine, or natural herbal extracts. New AEDs (GBP, LEV, LTG, and TGB) cause no, or very little, OS as opposed to other drugs (CBZ, PHT, PB, VPA, TPM, or OXC), which have pronounced albeit heterogeneous and dose-dependent effects. It is suggested that AEDs should be administered together with free radical sweepers (vitamins, trace elements, electrolytes, melatonin) and other anti-oxidizing substances. Conclusions: (1) Epileptic seizures and AEDs cause OS. The effects vary greatly depending, among other things, on the daily drug dose. (2) The findings of research using a variety of seizure models are more unequivocal than the findings of research on patients with epilepsy. This suggests that the relations among seizures, AEDs, OS etiology, and OS consequences are complex. (3) Since existing AEDs cause OS, it is necessary to develop a new approach to AED treatment. (4) It is important to know the patient's specific characteristics, including previous history, lifestyle, age, gender, weight, diet, environment, etc. They can be valuable tools to improve the quality of life of a person suffering from epilepsy. This concept of managing the patient health is called targeted medicine or personalized medicine.

show abstract

Epilepsy Treatment and Nutritional Intervention

Cited by 2 publications

References 147 publications

Oriental Medicine Woohwangchungsimwon Attenuates Kainic Acid-Induced Seizures and Neuronal Cell Death in the Hippocampus

Oriental Medicine Woohwangchungsimwon Attenuates Kainic Acid-Induced Seizures and Neuronal Cell Death in the Hippocampus

Free Radicals and Antioxidants: Opportunities for Enhancing Treatment of Epilepsy with Personalized Medicine

Contact Info

Product

Resources

About