The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes

Alkholy, Usama M.; Abdalmonem, Nermin; Zaki, Ahmed A.; Elkoumi, Mohamed A.; Hashim, Mustafa I. Abu; Basset, Maha A.A.; Salah, Hossam

doi:10.1016/j.jped.2017.12.005

Cited by 16 publications

(13 citation statements)

References 26 publications

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“…Although vitamin D 3 deficiency showed no association with the DM group, but, total vitamin E and α-tocopherol were strikingly exhibited to be associated with T2DM progression based on the HbA1c values. This is aligned with previous studies reporting the relationship between vitamin E status and the incidence of T2DM [ 15 , 48 , 49 , 50 , 51 ].…”

Section: Discussionsupporting

confidence: 92%

Correlation between Levels of Vitamins D3 and E in Type 2 Diabetes Mellitus: A Case-Control Study in Serdang, Selangor, Malaysia

et al. 2021

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An overview of vitamins D3 and E suggests micronutrient deficiency contributes to type 2 diabetes mellitus (T2DM). A case-control study was conducted to determine the status of plasma vitamins D3 and E isomers amongst diabetic Malaysians. Two groups were recruited for participation, one comprising fifty diabetic subjects (DM) and one comprising fifty non-diabetic (non-DM) subjects, in order to assess their plasma vitamin D3, calcium and vitamin E status. Glycaemic status (haemoglobin A1c, HbA1c; fasting blood glucose, FBG; C-Peptide) and lipid profiles (total cholesterol, TC; triglycerides, TG; low-density lipoprotein-cholesterol, LDL-C; high-density lipoprotein-cholesterol, HDL-C) were assessed, followed by anthropometric measurements. The Mann–Whitney U-test, Kruskal–Wallis and Spearman’s correlation coefficient were used to elucidate the association between levels of plasma vitamins D3 and E and T2DM. The vitamin D3 deficiency group (<20 ng/mL) showed a significant correlation (p < 0.05) with glycaemic status (HbA1c and FBG) and lipid profiles (HDL-C, LDL and TC). Spearman’s correlation demonstrated that vitamin D3 status is strongly correlated with HDL levels (p < 0.05). Similarly, plasma total vitamin E levels >4.9 μg/mL revealed significantly different FBG, HbA1c, C-Peptide, LDL, HDL and TC levels across both groups. Moreover, family history, smoking, waist circumference and HbA1c levels demonstrated a significant association (p < 0.05) with levels of vitamins D and E but not FBG and lipid profiles. This could be because the pre-diabetic status among the non-DM group influenced the outcomes of this study.

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Section: Discussionsupporting

confidence: 92%

Correlation between Levels of Vitamins D3 and E in Type 2 Diabetes Mellitus: A Case-Control Study in Serdang, Selangor, Malaysia

et al. 2021

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“…Differences may also be due to the severity of disease. New studies conducted among children with type 1 diabetes showed higher concentrations of vitamin E and CoQ10 in those with metabolically unbalanced diabetes compared to those with good glycemic control and healthy children [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Statin Therapy on the Plasma Concentrations of Retinol, Alpha-Tocopherol and Coenzyme Q10 in Children with Familial Hypercholesterolemia

Motkowski

Maciejczyk

Hryniewicka

et al. 2020

Cardiovasc Drugs Ther

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Purpose Familial hypercholesterolemia (FH) requires early treatment. However, statins, which are regarded the first-line therapy, have an influence on redox balance. Antioxidant vitamins are important for many metabolic processes in the developing body. There are few data available on the long-term safety of statin use in children. The aim of this study was to evaluate the influence of statin treatment in children with FH on plasma concentrations of antioxidant vitamins: retinol, alpha-tocopherol and coenzyme Q10. Methods The first study group consisted of 13 children aged 10–18 years treated with simvastatin for at least 6 months, and the second group comprised 13 age- and sex-matched children with hypercholesterolemia, in whom pharmacological treatment had not been applied yet. Analyses were performed using a high-performance liquid chromatograph coupled with a MS detector. Results The analysis did not reveal significant differences in the concentration of retinol, alpha-tocopherol or coenzyme Q10 between the studied groups. The adjustment of the concentrations of the vitamins to the cholesterol level also indicated no significant differences. We found no deficits in antioxidant vitamins in patients treated with statins, or any risk of adverse effects associated with an increase in their concentration. Conclusion There is no rationale for additional supplementation using antioxidant vitamins or modification of low-fat and low-cholesterol diet in pediatric patients treated with statins.

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“…Ubiquinone endogenous levels depend on the production and consumption rates within the organism. Ubiquinone levels are altered in some diseases associated with oxidative stress, including PD [ 57 , 58 , 59 , 60 ].…”

Section: Mitochondria-targeted Antioxidants Therapeutic Effect On mentioning

confidence: 99%

Antioxidant Therapeutics in Parkinson’s Disease: Current Challenges and Opportunities

et al. 2021

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Oxidative stress is considered one of the pathological mechanisms that cause Parkinson’s disease (PD), which has led to the investigation of several antioxidants molecules as a potential therapeutic treatment against the disease. Although preclinical studies have demonstrated the efficacy of these compounds to maintain neuronal survival and activity in PD models, these results have not been reflected in clinical trials, antioxidants have not been able to act as disease modifiers in terms of clinical symptoms. Translational medicine currently faces the challenge of redesigning clinical trials to standardize criteria when testing molecules to reduce responses’ variability. Herein, we discuss current challenges and opportunities regarding several non-enzymatic antioxidants’ therapeutic molecules for PD patients’ potential treatment.

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The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes

Abstract: Patients with type 1 diabetes, especially poorly controlled, had elevation of plasma vitamin E and coenzyme Q10 levels and decreased platelet redox status of coenzyme Q10, which may be an indicator of increased oxidative stress.

Cited by 16 publications

References 26 publications

Correlation between Levels of Vitamins D3 and E in Type 2 Diabetes Mellitus: A Case-Control Study in Serdang, Selangor, Malaysia

Correlation between Levels of Vitamins D3 and E in Type 2 Diabetes Mellitus: A Case-Control Study in Serdang, Selangor, Malaysia

Effect of Statin Therapy on the Plasma Concentrations of Retinol, Alpha-Tocopherol and Coenzyme Q10 in Children with Familial Hypercholesterolemia

Antioxidant Therapeutics in Parkinson’s Disease: Current Challenges and Opportunities

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