The antioxidant methyl 3-(3,5-di-<i>tert</i>-butyl-4-hydroxyphenyl)propionate

Li, Xiang; Wang, Zhigang; Chen, Hou-He; Liu, Shenggao

doi:10.1107/s2053229614021445

Cited by 14 publications

(5 citation statements)

References 21 publications

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“…In addition, the EC50 value of bee bread sample was measured as 80.08 ± 0.10 mg/mL. All values ranked it among the powerful antioxidant foods (Li et al, 2014). This high antioxidant property of EBB can be probably due to the functional compounds in its content such as phenolic compound (Methyl-3-(3,5-Ditertbutyl-4-Hydroxyphenyl)-Propionate), aromatic group (Benzo[G]Quinoline-2-Carboxylic-Acid), and terpenoid (Cholest-5-En-3-Ol(3Beta)) (Borawska et al, 2014;Greenland & Bowden, 1994;Khan et al, 2019).…”

Section: Resultsmentioning

confidence: 96%

Comprehensive Study on BeeBread: Palynological Analysis, Chemical Composition, Antioxidant and Cytotoxic Activities

Dervişoğlu

Çobanoğlu

YELKOVAN

et al. 2022

International Journal of Secondary Metabolite

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Bee bread is a bee product obtained as a result of fermentation of pollen stored by honey bees in the cells of the honeycomb. Palynological analysis, chemical composition, antioxidant activity of bee bread and its cytotoxic effect against human lung carcinoma (A549), human prostate cancer (DU 145) and human neuroblastoma (SH-SY5Y) cell lines were investigated in this study. 25 plant taxa were identified with palynological analysis. Fatty acids, cyclic, aromatic, phenolic, terpenoid, diterpen and metallic complex structures were seen in GC-MS results. FTIR consequence were compatible with GC-MS results and the structure types of FTIR results were seen in the dominant compounds of GC-MS results. Radical scavenging activity (RSA) of bee bread showed inhibition variability between 20.15 ± 0.68% and 93.18 ± 0.44% depending on the concentration. In addition, the EC50 value was measured as 80.08 ± 0.10 mg/mL. Bee bread exhibited moderately cytotoxic effect at all concentrations (15.625 - 2000 µg/mL) against A549, DU 145, and SH-SY5Y cell lines. Bee bread can be used in medical fields because of it’s antioxidant and anticancer properties.

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Section: Resultsmentioning

confidence: 96%

Comprehensive Study on BeeBread: Palynological Analysis, Chemical Composition, Antioxidant and Cytotoxic Activities

Dervişoğlu

Çobanoğlu

YELKOVAN

et al. 2022

International Journal of Secondary Metabolite

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“…Methyl ester of 3‐(3,5‐di‐tert‐butyl‐4‐hydroxyphenyl)‐propionic acid (Li et al . ), pyrrolo[1,2‐a]pyrazine‐1,4‐dione, hexahydro‐3‐(2‐methylpropyl) and pyrrolo[1,2‐a]pyrazine‐1,4‐dione, hexahydro‐3‐(phenylmethyl) (Ser et al . ) with retention time of 18·3, 18·5 and 22·9 min, respectively, are the three potent antioxidants in this FBE (Fig.…”

Section: Resultsmentioning

confidence: 99%

Simultaneous anti-diabetic and anti-vascular calcification activity of Nocardia sp. UTMC 751

Salimi

Jafari-Nodooshan

Zohourian

et al. 2018

Lett Appl Microbiol

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Actinobacteria are one of the best natural libraries for discovering drugs. Various commercial drugs have been developed against infectious and metabolic disorders from actinobacteria; however, there is no report on their simultaneous inhibitory effect against diabetes, a life-threatening disease, and its related pathological processes, like inflammation and vascular calcification (VC). In this research, after several screening, Nocardia sp. UTMC 751 was introduced as the first microbial source exhibiting a simultaneous inhibitory activity on the targets, including hyperglycaemia and protein glycation, and other involved pathological processes like inflammation and VC.

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“…), Methyl 3‐(3,5‐di‐tert‐butyl‐4‐hydroxyphenyl) propionate (Li et al . ), 1H‐Indole‐3‐propanoic acid (Bendheim et al . ), phenol, 2,4‐bis(1,1‐dimethylethyl) (Govindappa et al .…”

Section: Discussionmentioning

confidence: 99%

“…[Colour figure can be viewed at wileyonlinelibrary.com]a potential source of additional promising candidates for further investigation. Among the detected compounds 2 (3H)-Benzofuranone(Meng et al 2016), Methyl 3-(3,5di-tert-butyl-4-hydroxyphenyl) propionate(Li et al 2014), 1H-Indole-3-propanoic acid(Bendheim et al 2002), phenol, 2,4-bis(1,1-dimethylethyl)(Govindappa et al 2014;Padmavathi et al 2014;Rangel-S anchez et al 2014), hexadecanoic acid(Rahuman et al 2000;Kumar et al 2010;Aparna et al 2012), Cinnamic acid(Sova 2012) and 1H-Indole-3-carboxaldehyde(Naik et al 2012)…”

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confidence: 99%

Isolation and screening of rareActinobacteria, a new insight for finding natural products with antivascular calcification activity

et al. 2017

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Aim: Vascular calcification (VC) is a significant pathological process in some life-threatening diseases. Several pathological mechanisms, including transdifferentiation of vascular smooth muscle cells to osteoblast-like cells and apoptosis are involved in VC. Compounds with an inhibitory effect on these processes are potentially efficient medications. In consideration of the multiple biological activities of Actinobacteria, this research was aimed at finding anti-VC metabolite-producing Actinobacteria. Methods and Results: After the isolation and identification of Actinobacteria, the effect of their fermentation broth extracts on the apoptosis rate was measured using various methods, for example, ethidium bromide/acridine orange staining, DNA laddering and diphenylamine assays. The effect of the most effective fermentation broth extract of Actinobacteria (FBEA) on the mRNA expression of runt-related transcription factor 2 (Runx2) and osteopontin (OPN) was examined. Finally, the most effective FBEA was fractionated and the chemical composition of anti-VC fractions was analysed using GC-MS. Various VC inhibition rates were observed in the tested FBEA (20 lg ml À1 ; 17Á9-60Á15%). The inhibition of DNA fragmentation was 7-48%.The FBE with the greatest anticalcification activity belonged to Kribbella sp. UTMC 267 and, according to 16S rRNA analysis, Kribbella sancticallisti with a similarity of 98Á53% is its nearest neighbour. The FBE of Kribbella sp. UTMC 267 reduced Runx2 mRNA expression by 2Á95-fold and OPN mRNA expression by 28Á57-fold, both of which are considered significant (P < 0Á05). Finally, GC-MS analysis showed the existence of potent anti-oxidative and anti-inflammation agents in FBE of Kribbella sp. UTMC 267. Conclusions: Actinobacterial metabolites can provide a new strategy for treating VC diseases by reducing the expression of osteogenic genes, the apoptosis rate and oxidative stress. Significance and Impact of the Study: This study highlights the therapeutic potential of Kribbella sp. metabolites and Actinobacteria as a new natural source for drug discovery programs in the nonantibiotic bioactivity field.

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The antioxidant methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate

Cited by 14 publications

References 21 publications

Comprehensive Study on BeeBread: Palynological Analysis, Chemical Composition, Antioxidant and Cytotoxic Activities

Comprehensive Study on BeeBread: Palynological Analysis, Chemical Composition, Antioxidant and Cytotoxic Activities

Simultaneous anti-diabetic and anti-vascular calcification activity of Nocardia sp. UTMC 751

Isolation and screening of rareActinobacteria, a new insight for finding natural products with antivascular calcification activity

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