The antioxidant master glutathione and periodontal health

Bains, Vivek Kumar; Bains, Rhythm

doi:10.4103/1735-3327.166169

Cited by 44 publications

(37 citation statements)

References 118 publications

(219 reference statements)

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“…It has been shown that periodontal disease is associated with reduced levels of antioxidants enzymes[ 53 49 ] as superoxide dismutase (SOD), catalase, glutathione peroxidase, and nonenzymatic antioxidants as glutathione (major antioxidant molecule),[ 54 55 56 ] albumin,[ 13 ] and Vitamins C.[ 56 ] After periodontal therapy, oxidative stress decreased and antioxidant enzyme levels were significantly increased compared to basal levels while no improvement in any parameter was found in oral hygiene reinforcement group. [ 39 57 58 ] However, some investigators reported higher levels of enzymatic antioxidant which decreased significantly after periodontal therapy.…”

Section: Discussionmentioning

confidence: 99%

Impact of nonsurgical periodontal therapy on total antioxidant capacity in chronic periodontitis patients

Bansal¹,

Gupta

Bey

et al. 2017

J Indian Soc Periodontol

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Aim:The aim of this study was to determine the utility of plasma total antioxidant capacity (TAC) as marker of periodontal disease by estimating TAC of periodontally healthy and chronic periodontitis patients and the impact of scaling and root planning on total antioxidant status of periodontitis patients.Materials and Methods:Blood plasma samples were collected from randomly selected eighty individuals (40 periodontally healthy controls and 40 chronic periodontitis patients), with an age range of 20–45 years and were analyzed for TAC by ferric reducing antioxidant power assay. Scaling and root planing was performed in periodontitis patients, and TAC level was measured again after 3 weeks. Data were analyzed with t-test, using SPSS software (PSAW, Windows version 18.0).Results:The mean plasma TAC was significantly lower (792.33 ± 124.33 μmol/L, P < 0.001) in chronic periodontitis patients compared to healthy control (1076.08 ± 193.82 μmol/L). Plasma TAC level increased significantly (989.75 ± 96.80, P < 0.001) after scaling and root planing.Conclusions:An inverse relationship exists between plasma TAC and severity of chronic periodontitis suggesting disturbed oxidant-antioxidant balance in chronic periodontitis. Scaling and root planing resulted in the restoration of TAC to normal levels. These results are important from the perspective of including antioxidants in periodontal therapy regime to boost up body's antioxidant defense system and to reduce oxidative stress-mediated periodontal tissue damage. We concluded that TAC can be used as a biomarker to evaluate the health of periodontium.

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Section: Discussionmentioning

confidence: 99%

Impact of nonsurgical periodontal therapy on total antioxidant capacity in chronic periodontitis patients

Bansal¹,

Gupta

Bey

et al. 2017

J Indian Soc Periodontol

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“…To evaluate the response of the endogenous antioxidant glutathione to incremental concentrations of H 2 O 2 in each cell-line, we then determined the relative levels of OS that causes decompensation of the GSH/GSSG antioxidant system in the cell after 24 h exposure ( Figure 4A,B). In this study we profiled the cell lines using the glutathione system which has been reported as a reliable and sensitive marker of oxidative cellular status [47,48]. Furthermore, because the physiological variable of cell viability was used as a general indicator of the response of the cells to ROS (H 2 O 2 ), it is scientifically plausible that viability changes will be a reliable indicator of the total cellular antioxidant capacity, and therefore, a singular marker (glutathione) would provide enough insight on the differences in the total antioxidant capacities of the two cell lines.…”

Section: Discussionmentioning

confidence: 99%

Differential Sensitivity of Two Endothelial Cell Lines to Hydrogen Peroxide Toxicity: Relevance for In Vitro Studies of the Blood–Brain Barrier

Alamu

Rado

Ekpo

et al. 2020

Cells

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Oxidative stress (OS) has been linked to blood–brain barrier (BBB) dysfunction which in turn has been implicated in the initiation and propagation of some neurological diseases. In this study, we profiled, for the first time, two endothelioma cell lines of mouse brain origin, commonly used as in vitro models of the blood–brain barrier, for their resistance against oxidative stress using viability measures and glutathione contents as markers. OS was induced by exposing cultured cells to varying concentrations of hydrogen peroxide and fluorescence microscopy/spectrometry was used to detect and estimate cellular glutathione contents. A colorimetric viability assay was used to determine changes in the viability of OS-exposed cells. Both the b.End5 and bEnd.3 cell lines investigated showed demonstrable content of glutathione with a statistically insignificant difference in glutathione quantity per unit cell, but with a statistically significant higher capacity for the b.End5 cell line for de novo glutathione synthesis. Furthermore, the b.End5 cells demonstrated greater oxidant buffering capacity to higher concentrations of hydrogen peroxide than the bEnd.3 cells. We concluded that mouse brain endothelial cells, derived from different types of cell lines, differ enormously in their antioxidant characteristics. We hereby recommend caution in making comparisons across BBB models utilizing distinctly different cell lines and require further prerequisites to ensure that in vitro BBB models involving these cell lines are reliable and reproducible.

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“…It is suggested that the GSH in the bile protects the body against dietary xenobiotics, prevents lipid peroxidation in the lumen of the intestine, and defends the intestinal epithelium against oxygen radicals [27]. Glutathione is the most important redox regulator that controls inflammatory processes, thus damaging the periodontium [28].…”

Section: Glutathione (Gsh and Gssg)mentioning

confidence: 99%

Antioxidants and Periodontal Diseases

Talmaç¹,

Çalışır²

2019

Gingival Disease - A Professional Approach for Treatment and Prevention

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Excessive reactive oxygen species production plays an important role in the pathogenesis of various chronic inflammatory diseases, including periodontal disease. Reactive oxygen species could damage the cells and the tissues. In the pathogenesis of periodontal diseases, the increased PMN count and activity cause a high rate of ROS release. This leads to increased oxidative stress in periodontal tissues. Periodontal tissues require adequate levels of antioxidants to prevent tissue damage caused by reactive oxygen species. The use of antioxidants in the treatment of periodontal disease and periodontal health has gained importance in recent studies. Antioxidants can be used to treat periodontal disease locally or systemically. Therefore, this chapter focuses on the effects of antioxidant on periodontal tissues.

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The antioxidant master glutathione and periodontal health

Cited by 44 publications

References 118 publications

Impact of nonsurgical periodontal therapy on total antioxidant capacity in chronic periodontitis patients

Impact of nonsurgical periodontal therapy on total antioxidant capacity in chronic periodontitis patients

Differential Sensitivity of Two Endothelial Cell Lines to Hydrogen Peroxide Toxicity: Relevance for In Vitro Studies of the Blood–Brain Barrier

Antioxidants and Periodontal Diseases

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