The antioxidant effects of pomegranate extract on local and remote organs in a mesenteric ischemia and reperfusion model

Kılıç, Elif; Türkoğlu, Ahmet; Keleş, Ayşenur; Ekinci, Aysun; Kesgin, Siddika; Gümüş, Metehan

doi:10.1179/1351000215y.0000000013

Cited by 3 publications

(2 citation statements)

References 44 publications

(39 reference statements)

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“…Hepatocellular hydropic degeneration, hepatomegaly, steatosis, lobular inflammation, focal necrosis, cholestasis, portal zone inflammation, and increase in oxidative stress were reported with aforesaid doses of fluoxetine [ 9 – 11 ]. Some traditional drugs which have pleiotropic biological activity are currently used as supplements for treatment of different diseases such as cholestasis, hepatosteatosis, and hepatic ischemia [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Caffeic Acid Phenethyl Ester on Fluoxetine-Induced Hepatotoxicity: An Experimental Study

Yılmaz

Elbey

Yazgan

et al. 2016

BioMed Research International

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Background. The aim of the study was to analyse the effect of caffeic acid phenethyl ester (CAPE) on fluoxetine-induced hepatotoxicity in rats. Materials and Methods. Group I served as control. Group II received CAPE intraperitoneally. Group III received fluoxetine per orally. Group IV received fluoxetine and CAPE. The total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), and liver enzymes including paraoxonase-1 (PON-1), aspartate transaminase, and alanine transaminase levels were measured. Liver tissues were processed histopathologically for evaluation of liver injury and to validate the serum enzyme levels. Results. An increase in TOS and OSI and a decrease in TAC and PON-1 levels in serum and liver tissues of Group III were observed compared to Groups I and II. After treatment with CAPE, the level of TOS and OSI decreased while TAC and PON-1 increased in serum and liver in Group IV. Histopathological examination of the liver revealed hepatic injury after fluoxetine treatment and reduction of injury with CAPE treatment. Conclusion. Our results suggested that CAPE treatment provided protection against fluoxetine toxicity. Following CAPE treatment with fluoxetine-induced hepatotoxicity, TOS and OSI levels decreased, whereas PON-1 and TAC increased in the serum and liver.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of Caffeic Acid Phenethyl Ester on Fluoxetine-Induced Hepatotoxicity: An Experimental Study

Yılmaz

Elbey

Yazgan

et al. 2016

BioMed Research International

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“…Aerobic exercise can lead to free radicals increased production, reactive oxygen (ROS) and nitrogen (NRS) species, causing oxidative stress with potential damage to various organs (Liu et al, 2000 ). The ischemia reperfusion process along the exercise can cause changes in several organs, such as lungs, kidneys, liver, and intestine (Kiliç et al, 2015 ). Thus, launched the hypothesis that acute swimming exercise promotes oxidative stress and leads to changes in the rat ileum morphology; however, we observed that the exercise did not imbalance the reactive oxygen species in the ileum.…”

Section: Discussionmentioning

confidence: 99%

Acute Aerobic Swimming Exercise Induces Distinct Effects in the Contractile Reactivity of Rat Ileum to KCl and Carbachol

et al. 2016

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Aerobic exercise promotes short-term physiological changes in the intestinal smooth muscle associated to the ischemia-reperfusion process; however, few studies have demonstrated its effect on the intestinal contractile function. Thus, this work describes our observations regarding the influence of acute aerobic swimming exercise in the contractile reactivity, oxidative stress, and morphology of rat ileum. Wistar rats were divided into sedentary (SED) and acutely exercised (EX-AC) groups. Animals were acclimated by 10, 10, and 30 min of swimming exercise in intercalated days 1 week before exercise. Then they were submitted to forced swimming for 1 h with a metal of 3% of their body weight attached to their body. Animals were euthanized immediately after the exercise section and the ileum was suspended in organ baths for monitoring isotonic contractions. The analysis of lipid peroxidation was performed in order to determinate the malondialdehyde (MDA) levels as a marker of oxidative stress, and intestinal smooth muscle morphology by histological staining. Cumulative concentration-response curves to KCl were altered in the EX-AC with an increase in both its efficacy and potency (Emax = 153.2 ± 2.8%, EC50 = 1.3 ± 0.1 × 10−2 M) compared to the SED group (Emax = 100%, EC50 = 1.8 ± 0.1 × 10−2 M). Interestingly, carbachol had its efficacy and potency reduced in the EX-AC (Emax = 67.1 ± 1.4%, EC50 = 9.8 ± 1.4 × 10−7 M) compared to the SED group (Emax = 100%, EC50 = 2.0 ± 0.2 × 10−7 M). The exercise did not alter the MDA levels in the ileum (5.4 ± 0.6 μ mol/mL) in the EX-AC compared to the SED group (8.4 ± 1.7 μ mol/mL). Moreover, neither the circular nor the longitudinal smooth muscle layers thickness were modified by the exercise (66.2 ± 6.0 and 40.2 ± 2.6 μm, respectively), compared to the SED group (61.6 ± 6.4 and 34.8 ± 3.7 μm, respectively). Therefore, the ileum sensitivity to contractile agents is differentially altered by the acute aerobic swimming exercise, without affecting the oxidative stress and the morphology of ileum smooth muscle.

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The effects of roflumilast on the pancreas and remote organs in a cerulein-induced experimental acute pancreatitis model in rats

et al. 2016

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The antioxidant effects of pomegranate extract on local and remote organs in a mesenteric ischemia and reperfusion model

Abstract: These data may explain the positive protective effects of pomegranate based on the histopathologic findings in ischemic conditions in an intestinal IR injury model.

Cited by 3 publications

References 44 publications

Protective Effects of Caffeic Acid Phenethyl Ester on Fluoxetine-Induced Hepatotoxicity: An Experimental Study

Protective Effects of Caffeic Acid Phenethyl Ester on Fluoxetine-Induced Hepatotoxicity: An Experimental Study

Acute Aerobic Swimming Exercise Induces Distinct Effects in the Contractile Reactivity of Rat Ileum to KCl and Carbachol

The effects of roflumilast on the pancreas and remote organs in a cerulein-induced experimental acute pancreatitis model in rats

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