Protective Effects of Caffeic Acid Phenethyl Ester on Fluoxetine-Induced Hepatotoxicity: An Experimental Study

Abstract

Background. The aim of the study was to analyse the effect of caffeic acid phenethyl ester (CAPE) on fluoxetine-induced hepatotoxicity in rats. Materials and Methods. Group I served as control. Group II received CAPE intraperitoneally. Group III received fluoxetine per orally. Group IV received fluoxetine and CAPE. The total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), and liver enzymes including paraoxonase-1 (PON-1), aspartate transaminase, and alanine transaminase levels were measured. Liver tissues were processed histopathologically for evaluation of liver injury and to validate the serum enzyme levels. Results. An increase in TOS and OSI and a decrease in TAC and PON-1 levels in serum and liver tissues of Group III were observed compared to Groups I and II. After treatment with CAPE, the level of TOS and OSI decreased while TAC and PON-1 increased in serum and liver in Group IV. Histopathological examination of the liver revealed hepatic injury after fluoxetine treatment and reduction of injury with CAPE treatment. Conclusion. Our results suggested that CAPE treatment provided protection against fluoxetine toxicity. Following CAPE treatment with fluoxetine-induced hepatotoxicity, TOS and OSI levels decreased, whereas PON-1 and TAC increased in the serum and liver.

Histological Interfaces of Liver, Kidney and Cerebrum in Male Rats exposed to Fluoxetine

“…3.4). Histopathological examination of the liver revealed hepatic injury after fluoxetine treatment (Yilmaz et al, 2016). Furthermore, hepatocellular hydropic vacuolar degeneration, portal area and lobular inflammation were observed as a result of rat exposure to fluoxetine which agree with our results (Özden et al, 2005).…”

Vinpocetine attenuates fluoxetine-induced liver damage in rats; Role of Nrf2 and PPAR-γ

“…Fluoxetine is, a commonly prescribed selective serotonin reuptake inhibitor antidepressant, used to treat disorders such as major depressive disorder, panic disorder, and bulimia nervosa. 4 Indeed, impaired liver function is seen in 0.5%–3% of patients treated with antidepressants. The molecular mechanism by which FLX induces hepatotoxicity is not fully understood, but clinical and experimental studies suggest oxidative stress, inflammatory process, and apoptosis have a role in this toxicity.…”

“…4,5 Hepatic ischemia, necrosis, cholestasis, steatosis, portal zone inflammation, lobular inflammation, and hepatomegaly were reported with different doses of fluoxetine. 4,[6][7][8] Vinpo is a synthetic ethyl ester of vinca alkaloid vincamine, and it is widely prescribed as a cryoprotective agent in the treatment of memory disturbances, cognitive impairment, stroke, and dementia. 9 Vinpo is gaining interest from the academic and scientific community due to its higher safety profile and fewer side effects for long-term use.…”

The role of potassium channels on vasorelaxant effects of elabela in rat thoracic aorta

“…[ 12 ] All surgical operations and isolated tissue bath studies were performed as previously described. [ 13 , 14 ]…”