The antioxidant effects of coenzyme Q10 on albino rat testicular toxicity and apoptosis triggered by bisphenol A

Abstract

Polycarbonate plastics for packaging and epoxy resins are both made with the industrial chemical bisphenol A (BPA). This investigation looked at the histological structure, antioxidant enzymes, and albino rats' testis to determine how Coenzyme Q10 (CoQ10) impacts BPA toxicity. For the experiments, 18 adult male rats were broken into three groups: group 1 received no therapy, group 2 acquired BPA, and group 3 got daily BPA treatment accompanied by coenzyme Q10, one hour apart. All experiment done for 14 days. The biochemical biomarkers catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) were altered as a result of BPA exposure. The testicular histological architecture, which is made up of apoptosis, was also exaggerated. Furthermore, rats given BPA and CoQ10 treatment may experience a diminution in these negative BPA effects. These protective properties of CoQ10 may be correlated with the ability to eliminate oxidizing substances that can harm living species.The outcomes might support the hypothesis that CoQ10 prevented oxidative damage and boosted rats' stress responses when BPA was introduced. Thus, by shielding mammals from oxidative stress, CoQ10 aids in the growth and development of the animals.BPA is extremely hazardous to humans and can persist in tissues. Human reproductive functions are a worry due to human exposure to BPA, especially for occupational workers who are typically exposed to higher doses of BPA. As a result, in order to reduce the health risks, BPA usage must be minimized across a diverse range of industries, and improper plastic container handling must be prohibited. By giving CoQ10 to patients, BPA's harmful effects on reproductive structures and functions may be avoided.

Silk Fibroin Encapsulated Icariin Nanoparticles Mitigate Bisphenol A‐Induced Spermatogenesis Dysfunction

“…Increasing evidence demonstrates that BPA produced substantial harm to the testis, resulting in not only generally decreased germ cell numbers, low sperm quality, oxidative stress, and autophagy, but also aberrant apoptosis. [ 40 ] To investigate the potential correlation between the toxicity resistance of ICA‐SNPs and their antiapoptotic effects, we conducted a TUNEL assay to assess the level of apoptosis in the testicular tissue. The mice that were exposed to BPA exhibited an increase in the positive apoptotic signal.…”