The antioxidant and neuroprotective effects of the Psychotria camptopus Verd. Hook. (Rubiaceae) stem bark methanol extract contributes to its antiepileptogenic activity against pentylenetetrazol kindling in male Wistar rats

Pentylenetetrazole kindling-induced epilepsy rat models: Insight on the severity state, a comparative study

“…Moreover, these significant alterations in the CKEOD group were observed in both the pre-frontal cortex and the hippocampus; and it is clearly established that the pre-frontal cortex and the hippocampus are among the most vulnerable structures during epileptogenesis ( Roganovic et al 2019 ). In addition, many hypotheses suggest that the oxidative stress created during epileptogenesis would contribute to the development of refractory forms of epilepsy, which do not respond to currently available antiepileptic drugs ( Fokoua et al 2021 ).…”