The Aqueous Lyophilisate of Alchemilla Kiwuensis Engl. (Rosaceae) Displays Antiepileptogenic and Antiepileptic Effects on PTZ-induced Kindling in rats: Evidence of Modulation of Glutamatergic and GABAergic Pathways Coupled to Antioxidant Properties

Foutsop, Aurelien Fossueh; Ateufack, Gilbert; Adassi, Blesdel Maxwell; Yassi, Francis Bray; Kom, Tatiana Diebo; Noungoua, Chretien Mbeugangkeng; Petsou, Adolph; Ngoupaye, Gwladys Temkou

doi:10.1007/s11064-023-03982-0

Neurochem Res

2023

DOI: 10.1007/s11064-023-03982-0

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The Aqueous Lyophilisate of Alchemilla Kiwuensis Engl. (Rosaceae) Displays Antiepileptogenic and Antiepileptic Effects on PTZ-induced Kindling in rats: Evidence of Modulation of Glutamatergic and GABAergic Pathways Coupled to Antioxidant Properties

Aurelien Fossueh Foutsop,

Gilbert Ateufack,

Blesdel Maxwell Adassi

et al.

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2024

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Phytotherapeutic options for the treatment of epilepsy: pharmacology, targets, and mechanism of action

Waris,

Ullah,

Asim

et al. 2024

Front. Pharmacol.

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Epilepsy is one of the most common, severe, chronic, potentially life-shortening neurological disorders, characterized by a persisting predisposition to generate seizures. It affects more than 60 million individuals globally, which is one of the major burdens in seizure-related mortality, comorbidities, disabilities, and cost. Different treatment options have been used for the management of epilepsy. More than 30 drugs have been approved by the US FDA against epilepsy. However, one-quarter of epileptic individuals still show resistance to the current medications. About 90% of individuals in low and middle-income countries do not have access to the current medication. In these countries, plant extracts have been used to treat various diseases, including epilepsy. These medicinal plants have high therapeutic value and contain valuable phytochemicals with diverse biomedical applications. Epilepsy is a multifactorial disease, and therefore, multitarget approaches such as plant extracts or extracted phytochemicals are needed, which can target multiple pathways. Numerous plant extracts and phytochemicals have been shown to treat epilepsy in various animal models by targeting various receptors, enzymes, and metabolic pathways. These extracts and phytochemicals could be used for the treatment of epilepsy in humans in the future; however, further research is needed to study the exact mechanism of action, toxicity, and dosage to reduce their side effects. In this narrative review, we comprehensively summarized the extracts of various plant species and purified phytochemicals isolated from plants, their targets and mechanism of action, and dosage used in various animal models against epilepsy.

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Phytotherapeutic options for the treatment of epilepsy: pharmacology, targets, and mechanism of action

Waris,

Ullah,

Asim

et al. 2024

Front. Pharmacol.

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show abstract

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The Aqueous Lyophilisate of Alchemilla Kiwuensis Engl. (Rosaceae) Displays Antiepileptogenic and Antiepileptic Effects on PTZ-induced Kindling in rats: Evidence of Modulation of Glutamatergic and GABAergic Pathways Coupled to Antioxidant Properties

Cited by 1 publication

References 86 publications

Phytotherapeutic options for the treatment of epilepsy: pharmacology, targets, and mechanism of action

Phytotherapeutic options for the treatment of epilepsy: pharmacology, targets, and mechanism of action

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