The antioxidant and anti-inflammatory efficiency of hyaluronic acid after third molar extraction

Göçmen, Gökhan; Gönül, Onur; Oktay, Nihal Sehkar; Yarat, Ayşen; Göker, Kamil

doi:10.1016/j.jcms.2015.04.022

Cited by 55 publications

(44 citation statements)

References 21 publications

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“…Hyaluronic acid retains the water in aqueous solution and maintains the stiffness that acts as a antimictobal barrier, directly after HA application (15,23,24). Gocmen et al confirmed that HA has an anti-inflammatory effect and that it improves angiogenesis after one week following extraction (17). These results agree with our Pain scores on VAS decreased during follow-up period; for the control group from 2.68 to 0.36 and for the HA group from 3.04 to 0.60.…”

Section: Resultsmentioning

confidence: 99%

“…Owing to biocompatible features and participation in biological processes related to tissue healing, HA has become widely used in dentistry (15). The studies have demonstrated the beneficial role of HA on swelling, pain and anti-inflammatory efficiency in oral surgery (16,17). Furthermore, some authors reported its role in bone repair by facilitating cell's migration, proliferation and differentiation (18).…”

Section: Methodsmentioning

confidence: 99%

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Hyaluronic acid treatment outcome on the post-extraction wound healing in patients with poorly controlled type 2 diabetes: A randomized controlled split-mouth study

Marin¹,

Popović-Pejičić²,

Radošević-Carić³

et al. 2020

Med Oral

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Background: Hyaluronic acid is widely used in the medical field. However, there is a lack of research about its effect on patients with certain risks, such as compromised wound healing commonly found in patients with poorly controlled type 2 diabetes. The aim of this study is to investigate the efficacy of hyaluronic acid on the post-extraction wound healing and pain in patients with poorly controlled type 2 diabetes. Material and Methods: The randomized controlled split-mouth study was designed, which included 30 patients with poorly controlled type 2 diabetes with a bilaterally same teeth in the lower jaw for extraction. The sockets treated with 0.8% hyaluronic acid represented the study group, while the sockets where hyaluronic acid was not applied represented the control group. Wound closure rate (WCR), clinical scores in wound healing scale (WHS) and pain intensity in Visual analogue scale (VAS) were recorded. Patients were followed up on 5 th , 10 th , 15 th , 20 th , 25 th day after tooth extraction.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Hyaluronic acid treatment outcome on the post-extraction wound healing in patients with poorly controlled type 2 diabetes: A randomized controlled split-mouth study

Marin¹,

Popović-Pejičić²,

Radošević-Carić³

et al. 2020

Med Oral

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“…Half of the patients were randomly assigned to receive a local HA gel (0.8% [w/v]; Gengigel, Ricerfarma, Italy) following tooth removal (n=20) 5,6 . A 0.2 ml HA gel was applied immediately after M3 removal to the edge of the extraction socket.…”

Section: Methodsmentioning

confidence: 99%

Effects of hyaluronic acid on bleeding following third molar extraction

et al. 2017

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Objective To explore the effects of hyaluronic acid (HA) on bleeding and associated outcomes after third molar extraction.Methods Forty patients who had undergone molar extraction were randomly divided into two groups; 0.8% (w/v) HA was applied to the HA group (n=20) whereas a control group (n=20) was not treated. Salivary and gingival tissue factor (TF) levels, bleeding time, maximum interincisal opening (MIO), pain scored on a visual analog scale (VAS), and the swelling extent were compared between the two groups.Results HA did not significantly affect gingival TF levels. Salivary TF levels increased significantly 1 week after HA application but not in the control group. Neither the VAS pain level nor MIO differed significantly between the two groups. The swelling extent on day 3 and the bleeding time were greater in the HA group than in the control group.Conclusions Local injection of HA at 0.8% prolonged the bleeding time, and increased hemorrhage and swelling in the early postoperative period after third molar extractions.

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“…Other research includes the postoperative use of hyaluronic acid gel, which has anti-inflammatory effects, although oxidative stress and clinical results are similar by one week after surgery (27); platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), which proved very beneficial in the cicatrization of soft tissue and helped speed up the wound’s healing process (28); and photodynamic and ozone therapy, which reduce bleeding and exudate, decrease the wound’s temperature and improve the patient’s quality of life during the postoperative period (29). …”

Section: Discussionmentioning

confidence: 99%

The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction

Madrazo-Jiménez¹,

Rodríguez-Caballero²,

Serrera-Figallo³

et al. 2016

Med Oral

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BackgroundDespite efforts to prevent postoperative discomfort, there are still many immediate side effects associated with the surgical extraction of impacted lower third molars. Cicatrization is a physiological process through which the loss of integrity of oral mucosa is recovered and damaged tissues are repaired. Bexident Post (ISDIN, Spain) is a topical gel that contains chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol. While this gel has many clinical indications, there are no published clinical trials evaluating its use in impacted mandibular third molar surgery. This study aims to clinically evaluate the efficacy of a gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol on wound healing and reduction of postoperative side effects and complications after extraction of an impacted mandibular third molar.Material and MethodsA split-mouth design study was carried out on a total of 50 bilaterally and symmetrically impacted third molar extractions, which were randomly placed into either a control group (CG=25) or an experimental group (EG=25). Patients were all informed of the purpose of the study and provided written consent. All procedures were carried out by the same dental practitioner, in accordance with standard surgical protocol. A different dental practitioner, unaware of which treatment had been applied, provided follow-up care. The EG applied 10 ml of topical gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol to the surgical wound three times a day for 10 days, patients in the CG did not apply any gel.ResultsThe groups were homogeneous insofar as potentially confounding variables. No significant findings were found regarding postoperative swelling and pain. Neither of the groups displayed poor healing or infectious complications of the wound during the postoperative period. In all the recorded follow-ups (Day 7 p=0.001, and Day 14 p=0.01), the wound’s aesthetic appearance was better in the EG. Overall treatment tolerance was satisfactory and similar in both groups.ConclusionsThe gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not aid in patients’ postoperative comfort; however, improved wound healing was observed. Key words:Impacted lower third molar, postoperative wound healing, chitosan, chlorhexidine, allantoin, dexpanthenol, postoperative period.

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The antioxidant and anti-inflammatory efficiency of hyaluronic acid after third molar extraction

Cited by 55 publications

References 21 publications

Hyaluronic acid treatment outcome on the post-extraction wound healing in patients with poorly controlled type 2 diabetes: A randomized controlled split-mouth study

Hyaluronic acid treatment outcome on the post-extraction wound healing in patients with poorly controlled type 2 diabetes: A randomized controlled split-mouth study

Effects of hyaluronic acid on bleeding following third molar extraction

The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction

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