Hyaluronic acid treatment outcome on the post-extraction wound healing in patients with poorly controlled type 2 diabetes: A randomized controlled split-mouth study

Abstract

Background: Hyaluronic acid is widely used in the medical field. However, there is a lack of research about its effect on patients with certain risks, such as compromised wound healing commonly found in patients with poorly controlled type 2 diabetes. The aim of this study is to investigate the efficacy of hyaluronic acid on the post-extraction wound healing and pain in patients with poorly controlled type 2 diabetes. Material and Methods: The randomized controlled split-mouth study was designed, which included 30 patients with poorly controlled type 2 diabetes with a bilaterally same teeth in the lower jaw for extraction. The sockets treated with 0.8% hyaluronic acid represented the study group, while the sockets where hyaluronic acid was not applied represented the control group. Wound closure rate (WCR), clinical scores in wound healing scale (WHS) and pain intensity in Visual analogue scale (VAS) were recorded. Patients were followed up on 5 th , 10 th , 15 th , 20 th , 25 th day after tooth extraction.

Effect of Aging on Homeostasis in the Soft Tissue of the Periodontium: A Narrative Review

“…Based on these positive roles, hyaluronan is now actively used in the dental field [ 72 ]. Therefore, aging accompanying with progressive decline of hyaluronan severely impairs proliferating and regenerative capacities of oral fibroblasts, resulting in downregulation of ECM production, disorganization of ECM architecture, and inefficient wound healing [ 73 , 74 ]. Indeed, accumulating clinical evidence reveals that wound healing capacity after biopsy or periodontal surgery is higher in younger individuals [ 75 , 76 ].…”

Orodispersible hyaluronic acid film delivery for oral wound healing in rats

“… 7 HA was also effective in reducing the wound after labial frenectomy 8 and healing the extraction site in patients with uncontrolled type II diabetes. 9 Since HA is widely used in its gel form (e.g., Gengigel®; Ricerfarma, Milano, Italy), it can compromise drug delivery to the oral wound site due to the fluidity of saliva and volatility. Additionally, rubbing for 1–2 min to achieve the proper effect is difficult in practice.…”

Impact of Hyaluronic acid on healing of tongue ulcers in diabetic rats

“…previous study on free gingival grafts stated that HA accelerated re-epithelialization of the donor sites (25) . In other researches, HA was also effective in wound closure after labial frenectomy (26) , improving the extraction socket healing in patients with uncontrolled type II diabetes (27) .…”