The antioxidant activity of Vitamin C, DPPD and l-cysteine against Cisplatin-induced testicular oxidative damage in rats

Ahmed, Emad A.; Omar, Hossam El-Din M.; Elghaffar, Sary Khaleel Abd; Ragb, Sohair M.M.; Nasser, Ahmed Y.

doi:10.1016/j.fct.2011.02.002

Cited by 74 publications

(65 citation statements)

References 44 publications

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“…Still, administration of vitamin C, DPPD or L-cysteine before cisplatin injection had improved histologi- cal manifestations, and decreased number of apoptotic cells. [22] In our study, as an antioxidant, vitamin C was used before, and after administration of MTX, and similar results were obtained. Use of vitamin C before administration of MTX decreased MTX induced testicular injury which is a good example of protective effects of antioxidants.…”

Section: Discussionsupporting

confidence: 48%

“…Chlorogenic acid also protected seminiferous tubuli against deleterious effects of oxidative stress. Ahmed et al [22] evaluated antioxidant activity of vitamin C, DPPD, and L-cysteine against oxidative injury related to cisplatin use. They observed a significant drop in activities of antioxidants as superoxide dismutase and Glutation S transferase, contrary to marked increases in lipid peroxidation, and levels of total peroxidase, and superoxide anion.…”

Section: Discussionmentioning

confidence: 99%

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The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate

Sayılmaz

Karabulut

Özgörgülü

2016

Turkish Journal of Urology

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Objective: Methotrexate (MTX) leads to acute toxic side effects in tissues or organs containing rapidly dividing cells such as seminiferous tubules. In this study, we investigated the protective effects of vitamin C against MTX-induced injury in rat testis. Material and methods:A total of 31 rats were divided into 4 groups, including the control group. The study was completed within 4 weeks and the rats received daily doses of 2 mL/kg SF, 100 mg/kg vitamin C and 10 mg/kg/day MTX i.p according to their groups. The mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score were determined by histologic examination of each group. Results:The vitamin C + MTX group showed more similarity with the control group. Statistically significant results were achieved between groups as for mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score. When compared with the group which received vitamin C after MTX therapy, values for mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score were significantly higher in the group which received vitamin C before initiation of MTX therapy. Conclusion:Vitamin C decreased MTX-induced testicular histological injuries, especially when used before MTX therapy.

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate

Sayılmaz

Karabulut

Özgörgülü

2016

Turkish Journal of Urology

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“…It is well known that CP leads to a significant reduced antioxidant status in humans and animals. 45,46 On the other hand, in another study, Dengiz et al 47 reported that montelukast plus CP injection generally reversed the toxic effects of CP and numerically increased GSH levels. Similarly here, montelukast administration could not increase reduction of GSH levels, whereas montelukast therapy tended to ameliorate GSH enzymes to nearly the same level as controls.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Montelukast against Cisplatin-Induced Acute Renal Damage in Rats

et al. 2012

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Objective: In this study, the therapeutic and protective effects of montelukast against cisplatin (CP)-induced acute renal damage were investigated. Materials and Methods: Thirty-five female rats were divided into five groups as follows: (1) control, (2) montelukast (10 mg/kg daily for 10 days per-oral (p.o.), (3) CP (single dose 7 mg/kg intraperitoneally (i.p.)), (4) CP + montelukast (10 mg/kg daily for 10 days p.o., after 3 days of the injection of CP), (5) montelukast (10 mg/kg daily for 10 days p.o.) + CP (single dose 7 mg/kg i.p., after the last dose of montelukast). At the end of the experiment, malondialdehyde (MDA), a lipid peroxidation product, myeloperoxidase (MPO), and reduced glutathione (GSH) levels were determined in the renal tissue. Also, blood urea nitrogen (BUN) and creatinine (Cr) levels were assayed from the trunk blood samples. Results: CP treatment caused a significant elevation of MDA, MPO, BUN, and Cr levels when compared with the control group. Also, GSH levels were found to be reduced due to the CP treatment. Montelukast administration after CP injection ameliorated all of these parameters. Our histopathological findings (marked swelling of epithelial cells, tubular dilatation, tubular desquamation, and loss of brush border in the kidney) were consistent with the biochemical results. Conclusion: Montelukast treatment after CP injection exerted therapeutic effects against CP-induced acute kidney damage.

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“…Renin is an enzyme formed and released by the granule cells of the glomus (Ahmed et al, 2011). Renin catalyses the conversion of angiotensinogen (protein synthesized by the liver) to angiotensin I. Angiotensin I is converted by a converting enzyme into angiotensin II, which is biologically active (Covic et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Physiologic Human Fluids and Swelling Behavior of Hydrophilic Biocompatible Hybrid Ceramo-Polymeric Materials

Aversa¹,

Petrescu²,

Apicella³

et al. 2016

American Journal of Engineering and Applied Sciences

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All synthetic and natural materials to be used in biomedical applications that involve the contact with human body need to be investigated for their physical and chemical modification induced by the human physiological fluids contact and sorption. The development and testing in human physiological equivalent fluids of new hybrid biomaterials are presented. The role of water and its equilibrium modification in the human physiology is discussed and the swelling and sorption behavior in the physiological environment of a nanostructured and osteoconductive biomaterials based on Poly-Hydroxyl-Ethyl-Meth Acrylate matrix (pHEMA) filled with fumed amorphous nanosilica particles is presented. This material differently swells in presence of aqueous physiological solution fluid. Biological hybrid scaffolds for bone regeneration and growth made using synthetic materials able to correctly interact with the physiological fluids while inducing the growth of biological tissues may favor the birth in the medical field of a new class of hybrid materials. Our multidisciplinary approach explores in the this paper, novel ideas in modeling, design and fabrication of new nanostructured scaffolding biomaterials with enhanced functionality and improved interaction with OB cells.

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The antioxidant activity of Vitamin C, DPPD and l-cysteine against Cisplatin-induced testicular oxidative damage in rats

Cited by 74 publications

References 44 publications

The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate

The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate

Beneficial Effects of Montelukast against Cisplatin-Induced Acute Renal Damage in Rats

Physiologic Human Fluids and Swelling Behavior of Hydrophilic Biocompatible Hybrid Ceramo-Polymeric Materials

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