The Antiosteoporosis Effects of Yishen Bugu Ye Based on Its Regulation on the Differentiation of Osteoblast and Osteoclast

Abstract

Yishen Bugu Ye (YSBGY), a traditional Chinese medicine comprising 12 types of medicinal herbs, is often prescribed in China to increase bone strength. In this study, the antiosteoporotic effects of YSBGY were investigated in C57BL/6 mice afflicted with dexamethasone-(Dex-) induced osteoporosis (OP). The results showed that YSBGY reduced the interstitial edema in the liver and kidney of mice with Dex-induced OP. It also increased the number of trabecular bone elements and chondrocytes in the femur, promoted cortical bone thickness and trabecular bone density, and modulated the OP-related indexes in the femur and tibia of OP mice. It also increased the serum concentrations of type I collagen, osteocalcin, osteopontin, bone morphogenetic protein-2, bone morphogenetic protein receptor type 2, C-terminal telopeptide of type I collagen, and runt-related transcription factor-2 and reduced those of tartrate-resistant acid phosphatase 5 and nuclear factor of activated T cells in these mice, suggesting that it improved osteoblast differentiation and suppressed osteoclast differentiation. The anti-inflammatory effect of YSBGY was confirmed by the increase in the serum concentrations of interleukin-(IL-) 33 and the decrease in concentrations of IL-1, IL-7, and tumor necrosis factor-α in OP mice. Furthermore, YSBGY enhanced the serum concentrations of superoxide dismutase and catalase in these mice, indicating that it also exerted antioxidative effects. This is the first study to confirm the antiosteoporotic effects of YSBGY in mice with Dex-induced OP, and it showed that these effects may be related to the YSBGYinduced modulation of the osteoblast/osteoclast balance and serum concentrations of inflammatory factors. These results provide experimental evidence supporting the use of YSBGY for supporting bone formation in the clinical setting.

Combined Therapy of Yishen Zhuanggu Decoction and Caltrate D600 Alleviates Postmenopausal Osteoporosis by Targeting FoxO3a and Activating the Wnt/β-Catenin Pathway

“…Recently, combined therapy of TCM and western medicines has been considered as a promising therapeutic strategy for PMO. YSZG decoction as a TCM is widely used for enhancing bone strength, which exhibits antiosteoporosis effects [29]. Caltrate D600 is a western medicine that is of assistance in preventing and treating osteoporosis.…”

Traditional Chinese medicine in osteoporosis: from pathogenesis to potential activity

“…Further study revealed that QEP could prevent osteoblast ferroptosis and increase osteogenesis ( Shuai et al, 2019 ; Hao et al, 2022 ). Yangyang et al confirmed that Yishen Bugu Ye (YSBGY) showed potential anti-osteoporotic effects through the modulation of the osteoblast/osteoclast balance and serum concentrations of inflammatory factors ( Li et al, 2020 ). As a famous Chinese medicine preparation, Erzhi Wan (EZW) has a favorable anti-OP potential, mainly through inhibiting osteoclast bone absorption ( Zhang et al, 2008 ).…”

Corrigendum to “The Antiosteoporosis Effects of Yishen Bugu Ye Based on Its Regulation on the Differentiation of Osteoblast and Osteoclast”

“…In the article titled “The Antiosteoporosis Effects of Yishen Bugu Ye Based on Its Regulation on the Differentiation of Osteoblast and Osteoclast” [ 1 ], the authors identified a mistake in Figure 1 , where panel 2 of the liver samples was duplicated with panel 6. The authors confirm that this does not affect the results and conclusions of the article, and the corrected Figure 1 is as follows:…”