The antinociception evoked by anterior pretectal nucleus stimulation is partially dependent upon ventrolateral medullary neurones

Terenzi, Mariana Graciela; Rees, H.; Morgan, Simeon J.; Foster, Gregory D.; Roberts, M. W.

doi:10.1016/0304-3959(91)90209-g

Cited by 24 publications

(8 citation statements)

References 31 publications

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“…The ascending limb of this reflex loop projects through the contralateral DLF, probably to the parabrachial nuclei, and the descending limb projects through the ipsilateral DLF. The origin of the descending (excitatory and inhibitory) pathways is unknown, but the inhibitory one may originate in the parabrachial and ventrolateral regions of the medulla (Terenzi et al 1991, 1992; Rees & Roberts, 1993), i.e. they are different from the descending inhibitory pathway related to the periaqueductal gray and rostral ventromedial system (Basbaum & Fields, 1984; Fields et al 1991).…”

Section: Discussionmentioning

confidence: 99%

Spino‐bulbo‐spinal pathway mediating vagal modulation of nociceptive‐neuroendocrine control of inflammation in the rat

Miao¹,

Jänig

Jasmin

et al. 2001

The Journal of Physiology

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Stimulation of nociceptors by intradermal capsaicin produces depression of bradykinin (BK)-induced synovial plasma extravasation (PE) that is markedly enhanced by subdiaphragmatic vagotomy. This depression is mediated by the adrenal medullae, a propriospinal pathway between the afferent nociceptive input and preganglionic neurones projecting to the adrenal medullae, and a spino-bulbo-spinal pathway. Here we investigated the role of spinal ascending and descending pathways in the interaction between noxious and vagal afferent inputs, leading to inhibition of BK-induced PE mediated by the adrenal medullae. Nociceptors in the paw were activated by capsaicin and depression of BK-induced PE was measured in rats with intact or cut subdiaphragmatic vagus nerves. After cutting the dorsolateral funiculus (DLF) contralateral to the stimulated hindpaw (segmental level C5/C6 and T8/T9), depression of BK-induced PE was weak or absent both in rats with intact vagus nerves and in vagotomised rats, suggesting that an ascending excitatory pathway was interrupted. After cutting the DLF ipsilateral to the stimulated hindpaw, depression of BK-induced PE was already markedly enhanced, even in the absence of vagotomy. Ipsilateral DLF lesion (L2/L3) below the level of the spinal output to the adrenal medullae produced the same effect, suggesting interruption of a descending inhibitory pathway that relays the effect of vagal activity to the level of the capsaicin-induced nociceptive input. Contralateral and ipsilateral hemisection of the spinal cord (C5/C6) produced the same changes as the corresponding DLF lesions. Ipsi- or contralateral lesion of the dorsal funiculus at the spinal level T8/T9 had no effect on depression of BK-induced PE generated by cutaneous noxious stimulation of the forepaw. We suggest that noxious stimulation activates an ascending pathway of the spino-bulbo-spinal excitatory circuit which projects through the DLF contralateral to the nociceptive input, and that the inhibitory pathway which is activated by vagal afferent activity projects through the DLF ipsilateral to the nociceptive input.

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Section: Discussionmentioning

confidence: 99%

Spino‐bulbo‐spinal pathway mediating vagal modulation of nociceptive‐neuroendocrine control of inflammation in the rat

Miao¹,

Jänig

Jasmin

et al. 2001

The Journal of Physiology

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“…Fluoro Ruby-labeled terminations in the medial BPN from the dorsal column nuclei coincided with projection fields in adjacent sections formed by BDA-labeled ZI axons. In this regard it is interesting to note that the pretectal nuclei (in particular the anterior pretectal nucleus) like the ZI receive projections from the dorsal column nuclei (Wiberg and Blomqvist, 1984) and have been shown to play a role in stimulation-produced analgesia (Brandao et al, 1991;Terenzi et al, 1991;Wang et al, 1992).…”

Section: Potential Overlap Between Zi Terminations and Those Of The Dmentioning

confidence: 99%

Orthograde axonal transport studies of projections from the zona incerta and pretectum to the basilar pontine nuclei in the rat

Mihailoff

1995

J of Comparative Neurology

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This study employed orthogradely transported axonal tracers to demonstrate, in the rat, projections that reach the basilar pontine nuclei from the zona incerta or pretectal nuclei. Except for the most rostral levels, all subdivisions of the zona incerta give rise to substantive basilar pontine projections. Although some topographic differences exist among the temination patterns of various subdivisions, no clear somatotopically organized scheme is apparent. Most incertopontine axons descend to the basilar pons in association with fibers of the medial lemniscus or crus cerebri and reach ipsilateral ventral and medial pontine gray regions. A sparse number of terminals are evident in the contralateral medial pontine gray. The anterior pretectal axons also descend with the medial lemniscus and crus cerebri to enter exclusively the ipsilateral basilar pons where they terminate most densely in ventral and medial regions. Dual orthograde labeling experiments indicate that some pretectal terminal fields in the pontine gray are shared with incertopontine projections and with afferents from the dorsal column nuclei. This potential convergence of basilar pontine afferent projections is significant in light of 1) the known somatosensory input to the zona incerta and pretectum and 2), the fractured somatotopy of peripheral cutaneous inputs that arrive in the cerebellar cortex via mossy fibers. The present studies also employed electron microscopy to identify synaptic boutons formed by incerto- and pretectopontine axons, and they proved to be remarkably similar. Each is a medium to small-sized bouton that contains spheroidal synaptic vesicles and forms asymmetric membrane specializations. Most incerto- and pretectopontine boutons participate in glomerular synaptic complexes that include a single, centrally located bouton contacted on its perimeter by several types of dendritic profiles including shafts and spine-like appendages. A relatively small number of labeled boutons of either type contacts single, isolated dendritic elements in the neuropil. Taken together, these findings suggest that some basilar pontine neurons might receive convergent inputs from the zona incerta and pretectum as well as other somatosensory-related systems such as the dorsal column nuclei and sensorimotor cortex.

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“…First, the jaw‐opening reflex is more potently inhibited by electrical‐ and glutamate‐induced activation of the PAG than the APtN (Chiang et al., 1991). Second, RVM lesions, which profoundly depress the antinociceptive effects of PAG stimulation (Azami et al., 1982), barely affect the antinociception induced by APtN stimulation (Terenzi et al., 1991). Third, systemic injections of serotonin (5‐HT) receptor antagonists do not change the APtN stimulation effects (Rees, Prado, et al., 1987) but abolish PAG stimulation‐evoked antinociception (Carstens et al., 1981).…”

Section: Do the Aptn And Pag Stimulation Activate Similar Mechanisms?mentioning

confidence: 99%

“…Furthermore, electrical APtN stimulation excites cells in the RVL, whereas bilateral electrolytic RVL lesions, including LPGi, reduce the antinociceptive effect of APtN stimulation to 70% in the rat tail‐flick test (Terenzi et al., 1991). The RVL constitutes a large cell population that projects to the spinal cord (Basbaum & Fields, 1979; Skagerberg & Bjorklund, 1985) and is involved in the direct inhibition of spinal dorsal horn neurons (Basbaum & Fields, 1984; Willis, 1988).…”

Section: Mediation Involved In Descending Pathways From the Aptnmentioning

confidence: 99%

The role of the anterior pretectal nucleus in pain modulation: A comprehensive review

Genaro

Prado

2021

Eur J of Neuroscience

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A nociceptive stimulus initiates a cascade of events. An effective way to understand the physiology of pain sensation is to follow the nociceptive signaling pathway from the periphery to the central nervous system (CNS), with a focus on the neuroanatomical, neurochemical, and molecular mechanisms that integrate and modulate nociceptive signals.The term nociception is used to describe the signal following an injury that will be modulated at multiple steps within

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The antinociception evoked by anterior pretectal nucleus stimulation is partially dependent upon ventrolateral medullary neurones

Cited by 24 publications

References 31 publications

Spino‐bulbo‐spinal pathway mediating vagal modulation of nociceptive‐neuroendocrine control of inflammation in the rat

Spino‐bulbo‐spinal pathway mediating vagal modulation of nociceptive‐neuroendocrine control of inflammation in the rat

Orthograde axonal transport studies of projections from the zona incerta and pretectum to the basilar pontine nuclei in the rat

The role of the anterior pretectal nucleus in pain modulation: A comprehensive review

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