The role of the anterior pretectal nucleus in pain modulation: A comprehensive review

Genaro, Karina; Prado, Wiliam A.

doi:10.1111/ejn.15255

Cited by 3 publications

(1 citation statement)

References 263 publications

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“…Anterior pretectal nucleus inputs: APT is mainly involved in antinociception (Foster et al, 1989;Genaro and Prado, 2021) and is extensively connected, in addition to other structures, with pain and somatosensory related brainstem nuclei. In register with previous studies in rats (Bokor et al, 2005;Giber et al, 2008;Wanaverbecq et al, 2008), we show that APT axons are present across most of Po and leave dense clustered arborizations in the rostral region of the nucleus.…”

Section: Trigeminal Inputsmentioning

confidence: 99%

A combinatorial input landscape in the “higher-order relay” posterior thalamic nucleus

et al. 2022

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A large part of the thalamus is not directly involved in relaying ascending sensory inputs to the cerebral cortex. The functions and wiring of such "non-primary" nuclei remain unclear. The Posterior nucleus, a representative "non-primary" nucleus of the rodent thalamus, receives heavy and powerful inputs from cortical layer 5 (L5) cells. In addition, Po receives also some trigeminal, spinal and superior colliculus (SC) inputs, as well as powerful inhibitory inputs from the zona incerta (ZI) and anterior pretectal nucleus (APT). To elucidate to which extent these input systems converge or remain separate within Po, we first mapped the distribution of terminals immunolabeled for markers of glutamatergic or GABAergic neurotransmission and L5 terminals constitutively labeled in Rbp4-Cre;Ai14 mice. Besides, we retrogradely traced and quantified the sources of brain and spinal cord input reaching different Po regions. In addition, we compared bouton sizes in axons anterogradely labeled from the above input sources. Our data delineate several domains within Po, each dominated by specific sets of inputs. Cortical L5 afferents predominate in central and ventral Po. In contrast, large glutamatergic terminals from the trigeminal complex and spinal cord as well as GABAergic terminals from APT and ZI prevail in rostral and dorsal Po, and along the border with the ventral posteromedial nucleus. SC inputs preferentially target dorsal and caudal Po. These findings reveal multiple partly overlapping domains within Po. Hence, thalamic neuron subpopulations in different parts of Po may integrate diverse combinations of tactile, motor and pain-related inputs and give rise to functionally diverse thalamocortical subnetworks. Significance statementMany nuclei of the thalamus are not involved in relaying to cortex new information about the world or the body. The functions and wiring of such "non-primary" nuclei remain unclear. Here, we first mapped across the brain and spinal cord the origin of the input pathways reaching the Posterior nucleus, a typical non-primary relay nucleus.Then, we analyzed input distribution within the nucleus and, as a proxy for synaptic strength, the size of their axon terminals. We report a complex tridimensional mosaic of partly overlapping input-specific domains and significant bouton size differences. This wiring may allow diverse inputs to converge in graded combinatorial fashion onto thalamic cell subpopulations, hence giving rise to emergent computations and functionally diverse thalamocortical subnetworks.

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Section: Trigeminal Inputsmentioning

confidence: 99%

A combinatorial input landscape in the “higher-order relay” posterior thalamic nucleus

et al. 2022

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Single-neuron projectomes of mouse paraventricular hypothalamic nucleus oxytocin neurons reveal mutually exclusive projection patterns

Li,

Jiang,

et al. 2024

Neuron

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Targeted photothrombotic subcortical small vessel occlusion using in vivo real-time fiber bundle endomicroscopy in mice

Kim¹,

Choi

Moon³

et al. 2023

Biomed. Opt. Express

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The development of an accurate subcortical small vessel occlusion model for pathophysiological studies of subcortical ischemic stroke is still insignificant. In this study, in vivo real-time fiber bundle endomicroscopy (FBEµ) was applied to develop subcortical photothrombotic small vessel occlusion model in mice with minimal invasiveness. Our FBFµ system made it possible to precisely target specific blood vessels in deep brain and simultaneously observe the clot formation and blood flow blockage inside the target blood vessel during photochemical reactions. A fiber bundle probe was directly inserted into the anterior pretectal nucleus of the thalamus in brain of live mice to induce a targeted occlusion in small vessels. Then, targeted photothrombosis was performed using a patterned laser, observing the process through the dual-color fluorescence imaging. On day one post occlusion, infarct lesions are measured using TTC staining and post hoc histology. The results show that FBEµ applied to targeted photothrombosis can successfully generate a subcortical small vessel occlusion model for lacunar stroke.

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The role of the anterior pretectal nucleus in pain modulation: A comprehensive review

Cited by 3 publications

References 263 publications

A combinatorial input landscape in the “higher-order relay” posterior thalamic nucleus

A combinatorial input landscape in the “higher-order relay” posterior thalamic nucleus

Single-neuron projectomes of mouse paraventricular hypothalamic nucleus oxytocin neurons reveal mutually exclusive projection patterns

Targeted photothrombotic subcortical small vessel occlusion using in vivo real-time fiber bundle endomicroscopy in mice

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