The antimicrobial effect behind <i>Cannabis sativa</i>

Schofs, Laureano; Sparo, Mónica; Bruni, Sergio Fabian Sanchez

doi:10.1002/prp2.761

Cited by 59 publications

(36 citation statements)

References 102 publications

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“…Several terpenoids in the Cannabis essential oils have been demonstrated to have anti-microbial effect, which include the monoterpenes α-pinene, linalool, and limonene, and the bitter-tasting sesquiterpenes nerolidol, β-caryophyllene, and caryophyllene oxide [33,[74][75][76]. α-Pinene inhibited the growth of both Gram-positive bacteria (e.g., various Clostridium species, Enterococcus faecium, Streptococcus salivarius, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus pneumoniae) and Gramnegative bacteria (e.g., various Pseudomonas species), as well as the fungus Candida albicans [34,[77][78][79].…”

Section: Anti-microbial Activity Of Terpenoids In Cannabis Essential ...mentioning

confidence: 99%

Anti-Microbial Activity of Phytocannabinoids and Endocannabinoids in the Light of Their Physiological and Pathophysiological Roles

Sionov

Steinberg

2022

Biomedicines

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Antibiotic resistance has become an increasing challenge in the treatment of various infectious diseases, especially those associated with biofilm formation on biotic and abiotic materials. There is an urgent need for new treatment protocols that can also target biofilm-embedded bacteria. Many secondary metabolites of plants possess anti-bacterial activities, and especially the phytocannabinoids of the Cannabis sativa L. varieties have reached a renaissance and attracted much attention for their anti-microbial and anti-biofilm activities at concentrations below the cytotoxic threshold on normal mammalian cells. Accordingly, many synthetic cannabinoids have been designed with the intention to increase the specificity and selectivity of the compounds. The structurally unrelated endocannabinoids have also been found to have anti-microbial and anti-biofilm activities. Recent data suggest for a mutual communication between the endocannabinoid system and the gut microbiota. The present review focuses on the anti-microbial activities of phytocannabinoids and endocannabinoids integrated with some selected issues of their many physiological and pharmacological activities.

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Section: Anti-microbial Activity Of Terpenoids In Cannabis Essential ...mentioning

confidence: 99%

Anti-Microbial Activity of Phytocannabinoids and Endocannabinoids in the Light of Their Physiological and Pathophysiological Roles

Sionov

Steinberg

2022

Biomedicines

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“…Wang et al, reported that the activation of cannabinoid receptors reduces inflammation, fibrogenesis, and stimulates reepithelialization during skin wound healing [ 18 ]. Furthermore, there has also been great interest in the antibacterial activity of cannabinoids since 1950 and plenty of works have demonstrated their bacteriostatic and bactericidal effect predominantly against Gram-positive bacteria [ 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

et al. 2021

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Wounds represent a major healthcare problem especially in hospital-associated infections where multi-drug resistant strains are often involved. Nowadays, biomaterials with therapeutic molecules play an active role in wound healing and infection prevention. In this work, the development of collagen hydrogels loaded with silver nanoparticles and Cannabis sativa oil extract is described. The presence of the silver nanoparticles gives interesting feature to the biomaterial such as improved mechanical properties or resistance to collagenase degradation but most important is the long-lasting antimicrobial effect. Cannabis sativa oil, which is known for its anti-inflammatory and analgesic effects, possesses antioxidant activity and successfully improved the biocompatibility and also enhances the antimicrobial activity of the nanocomposite. Altogether, these results suggest that this novel nanocomposite biomaterial is a promising alternative to common treatments of wound infections and wound healing.

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“…CBN has shown the potential to have antibacterial activity [31]. CBC has shown to have anti-inflammatory and antinociceptive activity [32]. The common metabolites of Cannabis are shown in Figure 1.…”

Section: Cannabismentioning

confidence: 99%

Untitled

2021

BJSTR

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Ayurveda and herbal medicine have been around since the early days of medicine and have now been gaining recognition and popularity in modern medicine as secondary metabolites from plants have been identified to possess therapeutic value. Different parts of a plant can be used in herbal medicine, however, flowers, especially female flowers are the most concentrated regions for sites of production of beneficial secondary metabolites in cannabis, saffron and Epiphyllum oxypetalum. Research is slowly focusing on investigating the therapeutic activity of many medicinal plants as well as identifying its secondary metabolites and their role in the pharmacologic activity. Plants such as cannabis, saffron, and Epiphyllum oxypetalum are of growing interest as people are considering nutritionally important diets.

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The antimicrobial effect behind Cannabis sativa

Cited by 59 publications

References 102 publications

Anti-Microbial Activity of Phytocannabinoids and Endocannabinoids in the Light of Their Physiological and Pathophysiological Roles

Anti-Microbial Activity of Phytocannabinoids and Endocannabinoids in the Light of Their Physiological and Pathophysiological Roles

Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

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