The Antimicrobial Activity of Multipurpose Disinfecting Solutions in the Presence of Different Organic Soils

Yamasaki, Katsuhide; Mizuno, Yohei; Kitamura, Yoshiyuki; Willcox, Mark

doi:10.1097/icl.0000000000000694

Cited by 8 publications

(11 citation statements)

References 23 publications

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“…48 A recent study has also confirmed that P-I is effective against clinical isolates of bacterial species (P. aeruginosa from a patient with MK; and S. marcescens and Achromobacter xylosoxidans from CL cases), even in the presence of organic soils, and reports no adverse events due to P-I. 13 Furthermore, a study comparing a P-I MPS to a PQ-1 plus PHMB MPS found they were both effective against in vitro planktonic bacteria (standard strain S. marcescens; and clinically isolated P. aeruginosa, Delftia acidovorans, Stenotrophomonas maltophilia, S. aureus, and S. epidermidis), but only P-I was effective against biofilms isolated from CL cases. 85 Studies have also proven P-I is effective against in vitro clinically isolated 86 and known pathogenic 87,88 strains of Acanthamoeba cysts and trophozoites.…”

Section: Povidone-iodinementioning

confidence: 84%

“…Studies have found that the efficacy of MPS against ISO standard strains may differ in the presence of organic soil. [11][12][13] Organic soil found in the tear film may be transferred from a removed CL into a MPS and may neutralize the disinfecting agent. 9 The FDA standards require proof of efficacy against a laboratoryprepared organic soil composed of a mixture of killed Saccharomyces cerevisiae and inactivated fetal bovine serum.…”

Section: Preservatives In Mps -Standardizations For Efficacy and Safetymentioning

confidence: 99%

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Common Ophthalmic Preservatives in Soft Contact Lens Care Products: Benefits, Complications, and a Comparison to Non-Preserved Solutions

Bradley¹,

Sicks²,

Pucker³

2021

OPTO

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Purpose: Preservatives are essential for preventing contact lens (CL)-related microbial keratitis (MK). The purpose of this review is to summarize the current knowledge related to the use of common ophthalmic preservatives in CL care products with respect to both safety and efficacy. Methods: Manuscripts written in English were obtained by searching PubMed.gov with the term contact lens plus antimicrobial, benzalkonium chloride, biguanide, Aldox, polyquaternium, preservative, thimerosal, EDTA (ethylenediaminetetraacetic acid), chlorhexidine, or blister pack. Results: This review found that first-generation preservatives are no longer used in CL multipurpose solutions (MPS) due to their high levels of ocular toxicity. Modern, highmolecular-weight preservatives, including polyquaternium-1 (PQ-1) and biguanides (PHMB), are generally effective against bacteria, minimally effective against fungi, and not effective against Acanthamoeba. PQ-1 and PHMB are likely safe when used with CLs, but they may cause ocular adverse events, with roughly equal risk between the two preservatives. Some CL MPS contain both PQ-1 and PHMB, but no increased risk of adverse events has been reported when combining the two. Hydrogen-peroxide (H 2 O 2 ) solutions are effective against all common ocular microbes, including Acanthamoeba, and they have been proven safe with proper compliance. Povidone-iodine (P-I) solutions are not currently commercially available in North America, but they have been shown in other countries to be safe and effective. Conclusion:Patients should be monitored when using PQ-1 or PHMB-containing solutions since they have been associated with ocular adverse events. If events are detected, patients should be switched to an alternative solution. H 2 O 2 or P-I solutions are preferred for any patient who may expose their CLs to water because they are the only solution categories effective against Acanthamoeba.

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Section: Povidone-iodinementioning

confidence: 84%

Section: Preservatives In Mps -Standardizations For Efficacy and Safetymentioning

confidence: 99%

Common Ophthalmic Preservatives in Soft Contact Lens Care Products: Benefits, Complications, and a Comparison to Non-Preserved Solutions

Bradley¹,

Sicks²,

Pucker³

2021

OPTO

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“…This is an obvious difference from other multipurpose disinfecting solution and hydrogen peroxide–based products. A recent study investigating the antimicrobial efficacy of contact lens care products in the presence of the model tear organic soil reported that multipurpose disinfecting solution was significantly affected by the organic soil, unlike the solution containing povidone-iodine, which maintained its activity 48 …”

Section: Discussionmentioning

confidence: 99%

“…A recent study investigating the antimicrobial efficacy of contact lens care products in the presence of the model tear organic soil reported that multipurpose disinfecting solution was significantly affected by the organic soil, unlike the solution containing povidone-iodine, which maintained its activity. 48 These experiments have demonstrated that the number of bacteria in lens storage cases can be significantly reduced if appropriate lens and lens case hygiene is performed. Therefore, contact lens users should be recommended to, at a minimum, rinse and air-dry their lens cases when using cleadew and rinse, tissue-wipe, and air-dry when using Biotrue after contact lens disinfection.…”

Section: Article Informationmentioning

confidence: 98%

Effect of Hygiene Procedures on Lens Case Contamination with Povidone-Iodine or Multipurpose Disinfecting Solutions

Nakagawa¹,

Nakagawa²,

Willcox

et al. 2021

Optom Vis Sci

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SIGNIFICANCE:A multipurpose disinfecting solution (MPDS), which contains povidone-iodine (PI) as a disinfectant, has high disinfecting efficacy not only on planktonic bacterium but also on the case biofilms. The addition of case hygiene practice removed more bacteria from cases than MPDS alone. PURPOSE:This study compared the ability of two MPDSs, one containing PI and another containing polyaminopropyl biguanide and polyquaternium, to reduce bacterial numbers in solution or adhered to the cases following case hygiene procedures.METHODS: Bacterial strains (Delftia acidovorans, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Serratia marcescens, Staphylococcus aureus, and Staphylococcus epidermidis) were exposed to the MPDSs for the recommended disinfection times, and the viable number evaluated according to ISO 14729. Cases were inoculated with bacterial strains and incubated for 24 hours to allow for biofilm formation. Cases were disinfected with both disinfecting solutions for 4 hours and rinsed, followed by recapping or air-drying, or tissue-wiping and air-drying for 18 hours. The number of survivors was counted using standard culture techniques. RESULTS:Both products exceeded the recommended 3-log reduction against planktonic bacteria. Regarding biofilm, after rinsing and recapping wet, the numbers of D. acidovorans (mean difference [95% confidence interval] log 10 colony-forming units per case, −2.9 [0.8 to −4.6], P < .01), P. aeruginosa (−2.0 [0.5 to −3.1], P < .01), S. marcescens (−1.7 [0.8 to −3.5], P < .05), and S. epidermidis (−2.1 [0.6 to −3.5], P < .05) in PI cases were significantly lower than in the dual-disinfectant MPDS storage cases. After air-drying, the PI storage cases had significantly lower numbers of S. maltophilia (−2.6 [0.6 to −4.0], P < .01), D. acidovorans (−1.6 [0.7 to −3.3], P < .05), and S. aureus (−1.6 [0.7 to −3.1], P < .05). The addition of tissue-wiping reduced the bacterial numbers in the MPDS storage cases to levels in the PI storage cases. CONCLUSIONS: Contact lens users should be recommended to tissue-wipe and air-dry their lens storage cases after disinfection with regular MPDS.

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“…[19][20][21][22] The PVP-I system is an innovative disinfecting solution compared with an MPDS from the perspective of disinfecting efficacy, including stand-alone tests, biofilm, and lens surface or lens case contamination. 6,[23][24][25] Thus, in Japan, PVP-I system for rigid lenses is currently recommended for the care of orthokeratology lenses in the orthokeratology guidelines developed by the Japan Contact Lens Society. 26 In fact, the number of PVP-I system users is steadily increasing year by year.…”

mentioning

confidence: 99%

Advances in Contact Lens Care Solutions: PVP-I Disinfectant and HAD Wetting Agents From Japan

Itokawa,

Yamasaki,

Suzuki

et al. 2023

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Half of the individuals who wear contact lenses use reusable lenses that require proper care. Improper contact lens (CL) care and using inadequate disinfecting solutions can lead to lens contamination, CL-related microbial keratitis, and Acanthamoeba keratitis. Oxidative disinfecting solutions, such as hydrogen peroxide, show higher efficacy than multipurpose solutions. Povidone–iodine (PVP-I), an oxidative disinfectant used in ophthalmic surgery, has been proven to be safe and effective. The PVP-I system, a CL disinfecting solution developed in Japan, has demonstrated excellent antimicrobial and antiviral properties. Although CL discomfort does not have a risk of ocular disorders with poor visual prognosis, such as keratitis, CL discomfort can still lead to lens dropout and thus needs to be addressed. To mitigate CL discomfort, it is essential to use disinfecting solutions containing surfactants and wetting agents that improve wettability of the lens surface. A CL solution containing hyaluronic acid derivatives (HADs) as wetting agents that permanently adhere to the lens surface to improve wettability of the lens surface was developed in Japan. There is potential for HAD to be integrated into various solutions. This article reviews the efficacy of novel PVP-I–based disinfecting solution and HAD wetting agents.

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The Antimicrobial Activity of Multipurpose Disinfecting Solutions in the Presence of Different Organic Soils

Cited by 8 publications

References 23 publications

Common Ophthalmic Preservatives in Soft Contact Lens Care Products: Benefits, Complications, and a Comparison to Non-Preserved Solutions

Common Ophthalmic Preservatives in Soft Contact Lens Care Products: Benefits, Complications, and a Comparison to Non-Preserved Solutions

Effect of Hygiene Procedures on Lens Case Contamination with Povidone-Iodine or Multipurpose Disinfecting Solutions

Advances in Contact Lens Care Solutions: PVP-I Disinfectant and HAD Wetting Agents From Japan

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