The antihypertensive potential of flavonoids from Chinese Herbal Medicine: A review

Cao, Yi; Xie, Long; Liu, Kai; Liang, Yusheng; Dai, Xiaolin; Xian, Wang; Lu, Jing; Zhang, Xumin; Li, Xiaofang

doi:10.1016/j.phrs.2021.105919

Cited by 62 publications

(39 citation statements)

References 137 publications

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“…The authors reported that hesperidin induced apoptosis in several cancer cells like breast, ovary, prostate, and colon, and it showed hepatoprotective effects against the development of hepatocellular carcinoma. For many of the flavonoids (quercetin, rutin, catechin, epicatechin) identified in our samples, an antihypertensive effect was found [ 38 ]. Quercetin, kaempferol, and rutin also possessed in vivo and in vitro hypoglycemic effects studied through various mechanisms of action [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and DNA-Protective Potentials, Main Phenolic Compounds, and Microscopic Features of Koelreuteria paniculata Aerial Parts

et al. 2022

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Interest in plant extracts as a natural source of antioxidants has grown significantly in recent years. The tree species Koelreuteria paniculata deserves attention due to its wide distribution, good adaptability, and growth to the degree of invasiveness in a number of European countries. The purpose of the present study was to analyze flavonoids and phenolic acids of the ethanol extracts from aerial parts of K. paniculata and to screen their antioxidant and DNA-protective activity. HPLC profiling revealed the presence of five flavonoids, with rutin (4.23 mg/g DW), hesperidin (2.97 mg/g DW), and quercetin (2.66 mg/g DW) as the major ones in the leaves, and (−)-epicatechin (2.69 mg/g DW) in the flower buds. Among the nine phenolic acids identified, rosmarinic, p-coumaric, salicylic, vanillic, and gallic acids were the best represented. All the extracts tested showed in vitro antioxidant activity that was determined by DPPH, ABTS, FRAP, and CUPRAC assays. The highest activity was recorded in the flower parts (in the range from 1133 to 4308 mmol TE/g DW). The DNA-protective capacity of the flower and stem bark extracts from the in vitro nicking assay performed, as well as the main diagnostic microscopic features of the plant substances, are given for the first time. According to the results obtained, the aerial parts of K. paniculata could be valuable sources of natural antioxidants.

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Section: Discussionmentioning

confidence: 99%

Antioxidant and DNA-Protective Potentials, Main Phenolic Compounds, and Microscopic Features of Koelreuteria paniculata Aerial Parts

et al. 2022

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“… 8 Growing evidence reveals that an administration of puerarin efficiently fights age‐related cellular and molecular inflammatory events in the cardiovascular and cerebrovascular systems (Figure 1 ). 7 , 8 , 9 , 10 Puerarin further diminishes the structural and functional adverse remodeling in the cardiovascular system, which can eventually fights diabetes, hypertension, atherosclerosis, and stroke, which are markedly increased with advancing age (Figure 1 ). 2 , 10 , 11 This mini review addresses recent advances in how puerarin combats the structural and functional inflammatory remodeling in the age‐associated cardiovascular and cerebrovascular disorders.…”

Section: Introductionmentioning

confidence: 99%

Effects of puerarin on chronic inflammation: Focus on the heart, brain, and arteries

2021

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Age‐associated increases in physical and mental stress, known as allostatic load, could lead to a chronic low‐grade inflammation in the heart, brain, and arteries. This low‐grade inflammation potentially contributes to adverse structural and functional remodeling, such as intimal medial thickening, endothelial dysfunction, arterial stiffening, cardiac hypertrophy and ischemia, and cognitive decline. These cellular and tissue remodeling is the fertile soil for the development of age‐associated structural and functional disorders in the cardiovascular and cerebrovascular systems in the pathogenesis of obesity, type II diabetes, hypertension, atherosclerosis, heart dysfunction, and cognitive decline. Growing evidence indicates that puerarin, a polyphenol, extracted from Puerara Labota , efficiently alleviates the initiation and progression of obesity, type II diabetes, hypertension, atherosclerosis, cardiac ischemia, cardiac arrythmia, cardiac hypertrophy, ischemic stroke, and cognition decline via suppression of oxidative stress and inflammation. This mini review focuses on recent advances in the effects of puerarin on the oxidative and inflammatory molecular, cellular, tissue events in the heart, brain, and arteries.

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“…These results have suggested the importance of vegetables in the prevention of hypertension in a time-specific manner. Vegetables are also known to include many dietary polyphenols such as flavonoids, and their treatment or prevention of hypertension (43). As previously stated, catechin, a type of flavonoid, suppressed the elevation of postprandial glucose more effectively when taken in the evening than in the morning, suggesting that the metabolic response of polyphenols may depend on their intake timing (21).…”

Section: Discussionmentioning

confidence: 97%

Association Between Na, K, and Lipid Intake in Each Meal and Blood Pressure

et al. 2022

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Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide, and one of the most significant risk factors for CVDs is high blood pressure. Blood pressure is associated with various nutrients, such as sodium, potassium, and cholesterol. However, research focusing on the timing of intake of these nutrients and blood pressure has not been conducted. In this study, we used dietary data and a questionnaire asking about the sleep, physical activity, and blood pressure, collected from the food-log app “Asken” (total N = 2,402), to investigate the relationship between the dietary data of nutrient intake in the breakfast, lunch, and dinner and blood pressure. Daily total intake of various nutrients such as sodium, sodium-to-potassium ratio, total energy, lipid, carbohydrate, and saturated fat showed a significant association with blood pressure depending on the meal timing. From multiple regression analysis, eliminating the confounding factors, lunch sodium-to-potassium ratio, dinner energy, lipid, cholesterol, saturated fat, and alcohol intake were positively associated with blood pressure, whereas breakfast protein and lunch fiber intake showed a negative association with blood pressure. Our results suggest that nutrient intake timing is also an important factor in the prevention of high blood pressure. Our study provides possibilities to prevent hypertension by changing the timing of nutrient intake, especially sodium, together with potassium and lipids. However, because our research was limited to food-log app users, broader research regarding the general population needs to be conducted.

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The antihypertensive potential of flavonoids from Chinese Herbal Medicine: A review

Cited by 62 publications

References 137 publications

Antioxidant and DNA-Protective Potentials, Main Phenolic Compounds, and Microscopic Features of Koelreuteria paniculata Aerial Parts

Antioxidant and DNA-Protective Potentials, Main Phenolic Compounds, and Microscopic Features of Koelreuteria paniculata Aerial Parts

Effects of puerarin on chronic inflammation: Focus on the heart, brain, and arteries

Association Between Na, K, and Lipid Intake in Each Meal and Blood Pressure

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