The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-α and free fatty acids

El‐Moselhy, Mohamed A.; Taye, Ashraf; Sharkawi, Sara Shaaban; El-Sisi, Suzan F. I.; Ahmed, Ahmed Fahmy

doi:10.1016/j.fct.2011.02.004

Cited by 166 publications

(113 citation statements)

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“…Long-term curcumin administration in mice has been shown to improve insulin signaling and glucose disposal by attenuating inflammation and obesity [17,26] . However, it is not clear whether curcumin could exert its insulinsensitizing action by anti-oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice

Wang²,

Gao³

et al. 2012

WJD

208

134

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AIM:To investigate the signaling mechanism of antioxidative action by curcumin and its impact on glucose disposal. METHODS:Male C57BL/6J mice were fed with either a normal diet (n = 10) or a high fat diet (HFD) (n = 20) to induce obesity and insulin resistance. After 16 wk, 10 HFD-fed mice were further treated with daily curcumin oral gavage at the dose of 50 mg/kg body weight (BW) (HFD + curcumin group). After 15 d of the curcumin supplementation, an intraperitoneal glucose tolerance test was performed. Fasting blood samples were also collected for insulin and glucose measurements. Insulin-sensitive tissues, including muscle, adipose tissue and the liver, were isolated for the assessments of malondialdehyde (MDA), reactive oxygen species (ROS) and nuclear factor erythroid-2-related factor-2 (Nrf2) signaling. RESULTS:We show here that in a HFD mouse model, short-term curcumin gavage attenuated glucose intolerance without affecting HFD-induced BW gain. Curcumin also attenuated HFD-induced elevations of MDA and ROS in the skeletal muscle, particularly in its mitochondrial fraction, but it had no such an effect in either adipose tissue or the liver of HFD-fed mice. Correspondingly, in skeletal muscle, the levels of total or nuclear content of Nrf2, as well as its downstream target, heme oxygenase-1, were reduced by HFD-feeding. Curcumin intervention dramatically reversed these defects in Nrf2 signaling. Further analysis of the relationship of oxidative stress with glucose level by a regression analysis showed a positive and significant correlation between the area under the curve of a glucose tolerance test with MDA levels either in muscle or muscular mitochondria. CONCLUSION:These findings suggest that the shortterm treatment of curcumin in HFD-fed mice effectively ameliorates muscular oxidative stress by activating Nrf2 function that is a novel mechanism for its effect in improving glucose intolerance. Key words: Oxidative stress; Insulin resistance; Glucose tolerance; Nuclear factor erythroid-2-related factor-2; Curcumin; Mitochondria

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Section: Discussionmentioning

confidence: 99%

Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice

Wang²,

Gao³

et al. 2012

WJD

208

134

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“…Most of the studies have been focused on its major active principle called curcumin and the yellow pigmented fraction of C. longa, which contains curcuminoids chemically related to curcumin (57). In this context, the antihyperglycemic effects produced by these compounds have been investigated (58) and the alpha-glucosidase inhibitory activity of curcuminoids and their analogs have been remarked (59) as well as the inhibitory potential of the water-soluble protein fraction of turmeric rhizome (60). Isopropanol and acetone extracts of Curcuma longa L were among the eleven Ayurvedic Indian medicinal plants that were recently screened for their pancreatic alpha-amylase inhibitory activity (29), presenting an IC 50 value of 0.16 µg/ml and 7.4 µg/ml, respectively.…”

Section: Curcuma Longa L (Zingiberaceae)mentioning

confidence: 99%

Antidiabetic effects of natural plant extracts via inhibition of carbohydrate hydrolysis enzymes with emphasis on pancreatic alpha amylase

Etxeberría

Garza²,

Campión³

et al. 2012

Expert Opinion on Therapeutic Targets

313

179

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Importance of the field: The increasing prevalence of type 2 diabetes mellitus and the negative clinical outcomes observed with the commercially available anti-diabetic drugs have led to the investigation of new therapeutic approaches focused on controlling postprandrial glucose levels. The use of carbohydrate digestive enzyme inhibitors from natural resources could be a possible strategy to block dietary carbohydrate absorption with less adverse effects than synthetic drugs. Areas covered in this review: This review covers the latest evidence regarding in vitro and in vivostudies in relation to pancreatic alpha-amylase inhibitors of plant origin, and presents bioactive compounds of phenolic nature that exhibit anti-amylase activity.What the reader will gain: The state of the art of the search for new pancreatic alpha amylase inhibitors of plant origin for the treatment of type 2 diabetes mellitus.Take home message: Pancreatic alpha-amylase inhibitors from traditional plant extracts are a promising tool for diabetes treatment. Many studies have confirmed the alpha-amylase inhibitory activity of plants and their bioactive compounds in vitro, but few studies corroborate these findings in rodents and very few in humans. Thus, despite some encouraging results, more research is required for developing a valuable anti-diabetic therapy using pancreatic alpha-amylase inhibitors of plant origin.Keywords: alpha-amylase; flavonoids; proanthocyanidins; tannins; type 2 diabetes mellitus 2 IntroductionDiabetes mellitus is one of the world´s major diseases, with an estimation of 347 million adults affected in 2011 (1). Type 2 diabetes mellitus, by far the most common type, is a metabolic disorder of multiple etiology characterized by carbohydrate, lipid and protein metabolic disorders that includes defects in insulin secretion, almost always with a major contribution of insulin resistance (2). These abnormalities could lead to lesions such as retinopathy, nephropathy, neuropathy, and angiopathy (3).In this context, the inhibition of carbohydrate digestive enzymes is considered a therapeutic tool for the treatment of type 2 diabetes (4). The most important digestive enzyme is pancreatic alpha-amylase (EC 3.2.1.1), a calcium metalloenzyme that catalyzes the hydrolysis of the alpha-1,4 glycosidic linkages of the starch, amylose, amylopectin, glycogen, and various maltodextrins and is responsible of most of starch digestion in humans. A second enzyme named alpha-glucosidase or maltase (EC 3.2.1.20) catalyzes the final step of the digestive process of carbohydrates acting upon 1,4-alpha bonds and giving as a result glucose (4).A positive correlation between human pancreatic alpha-amylase (HPA) activity and the increase in postprandial glucose levels has been shown, demonstrating the relevance of suppressing postprandial hyperglycemia (PPHG) in the treatment of type 2 diabetes (5). The ability of the alpha-amylase enzyme inhibitors to avoid dietary starch to be digested and absorbed in the organism has allowed to designat...

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“…In diabetic nephropathy, excretion of larger amounts of higher molecular weight proteins and renal tubular enzymes takes place. It was observed that the hyperglycaemic animals fed on a curcumin diet reduced excretion of these proteins and urinary enzymes significantly than control diet fed rats (26). In different studies, it was indicated that curcumin and turmeric delayed cataract in rats in streptozotocin-induced hyperglycaemia (28).…”

Section: Curcuma Longa (Turmeric)mentioning

confidence: 96%

“…El-Moselhy et al, in their study, described that an oral dose of 80 mg of curcumin, given for 60 and 15 days to rats with induced Type 2 diabetes and high fat diet insulin resistance, had antidiabetic activity (26), while another study conducted in 2012 reported that dietary curcumin was effective in controlling the increased levels of fasting blood glucose (27).…”

Section: Curcuma Longa (Turmeric)mentioning

confidence: 99%

Recent Progress for the Utilization of Curcuma longa, Piper nigrum and Phoenix dactylifera Seeds against Type 2 Diabetes

Khaliq¹,

Sarfraz²,

Ashraf³

2016

West Indian Med J

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The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-α and free fatty acids

Cited by 166 publications

References 70 publications

Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice

Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice

Antidiabetic effects of natural plant extracts via inhibition of carbohydrate hydrolysis enzymes with emphasis on pancreatic alpha amylase

Recent Progress for the Utilization of Curcuma longa, Piper nigrum and Phoenix dactylifera Seeds against Type 2 Diabetes

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