Recent Progress for the Utilization of Curcuma longa, Piper nigrum and Phoenix dactylifera Seeds against Type 2 Diabetes

Khaliq, Tanweer; Sarfraz, Maliha; Ashraf, Muhammad Aleem

doi:10.7727/wimj.2016.176

Cited by 19 publications

(18 citation statements)

References 30 publications

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“…Similar to P. amaryllifolius, V. negundo and P. nigrum showed greater than 80% inhibition. The anti-diabetic properties of V. negundo and P. nigrum have been welldocumented by many research studies [47][48][49][50][51] , but most of them involved in vivo studies and no inhibitory pathways were illustrated. Betulinic acid, one of the compounds present in V. negundo leaves, was reported to have potent PTP1B inhibition activity 52 .…”

Section: Discussionmentioning

confidence: 99%

Docking-based virtual screening in search for natural PTP1B inhibitors in treating type-2 diabetes mellitus and obesity

et al. 2020

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Introduction: Growing incidence of type-2 diabetes mellitus (T2DM), together with obesity, shows the complexity and progressive nature of these metabolic disorders and alarms the necessity to explore new and alternative therapeutic pathways and drugs. Diabetes has also been proven to be a key cause of premature aging through different mechanisms. Understanding these mechanisms could lead us to manage diabetes more efficiently, thus curtailing its age-related complications. Insulin and leptin resistance are the most common pathophysiological link between T2DM and obesity. Protein tyrosine phosphatase 1B (PTP1B) is thought to interfere with glucose homeostasis and satiety through down-regulation of insulin and leptin signaling pathways. Thus, drugs that are potent to impede this enzyme should be effective in treating T2DM and obesity. Method: In line with that, our current study involved screening of potent PTP1B inhibitors from the Natural Product Discovery System (NADI) database using in silico virtual screening and in vitro PTP1B inhibition study. The compounds that showed promising interaction with PTP1B catalytic site were traced down to their plant of origin. Further, the extracts of the plants were tested in vitro for PTP1B inhibition activity. Results: Our results showed promising PTP1B inhibition activity of Pandanus amaryllifolius, Vitex negundo and Piper nigrum with 94.38%, 89.03% and 81.39% inhibition, respectively. Conclusion: Therefore, the compounds of these plants might be an attractive option to develop drugs for T2DM and obesity.

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Section: Discussionmentioning

confidence: 99%

Docking-based virtual screening in search for natural PTP1B inhibitors in treating type-2 diabetes mellitus and obesity

et al. 2020

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“…Установено е, че етанолният екстракт на куркума има по-висока хипогликемична активност. [22] Антидиабетната активност на куркумина се дължи на инхибирането от негова страна на α-глюкозидазата. Установено е, че един от куркуминоидите (бис-деметоксикуркумин) показва най-голяма антихипергликемична активност, което е предпоставка за разработването на нови лекарствени продукти, които да се прилагат при пациенти, страдащи от диабет.…”

Section: въведениеunclassified

The Benefits of Curcumin in Various Diseases and the Extension of Its Application Through Various Technological Approaches

Argilashki¹,

Koleva²,

Hadzhieva³

2018

KIJ

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Turmeric is a plant that is widely used as a spice, and is also imposed in Ayurveda and Chinese medicin as a healing remedy.Indian traditional medicine has successfully established the use of turmeric for wound healing, rheumatic disorders, gastrointestinal symptoms, deworming, rhinitis and as a cosmetic. Turmeric (Curcuma Longa L.) is a perennial, herbaceous plant belonging to the family of Ginger ( Zingiberaceae). The usable part is the rhizome, which is cylindrical, often branched, on the outside is brown, inside is intense yellow with bitter taste and strong aroma.In the review, we present contemporary studies exploring the nature of turmeric. Due to its polyphenolic chemical structure curcumin has an anti-inflammatory, cholecinetic and antioxidant effect. These characteristics determine the use of curcumin for various diseases - diabetes, arthritis, Alzheimer's, asthma and heart failure, psoriasis, dermatitis, cancers, ophthalmic diseases, uroinfections, acne, vitiligo, etc. A limiting factor for the widespread use of curcumin in medicine is its physico-chemical instability, extremely low water solubility, poor bioavailability, rapid metabolism, which make it difficult to use it as a therapeutic agent. That is why in the present review we also present various technological approaches, such as: complexation with cyclodextrin; the use of adjuvants such as piperine that prevents glucuronidation and the rapid elimination of curcumin; use of liposomal curcumin; use of curcumin structural analogs; application of curcumin in complexes with phospholipids; use of nanoparticles; inclusion in emulsions. These methods aim at increasing the solubility, optimizing the absorption and the bioavailability of curcumin, leading to the expansion of the turmeric application areas and offering additional opportunities for targeted therapy or prophylaxis of specific diseases.In order to prevent various diseases in the future, it is necessary to increase the use of curcumin as an active agent both in the diet and in the form of concentrated sources such as tablets, capsules and other dosage forms.

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“…In addition, ingredients of the above mixture are well-known antidiabetic herbal therapeutics in traditional medicine that have been extensively used to manage diabetes not only in Sri Lanka but also in many South Asian countries. Recent scientific studies have disclosed their evidences for potential antidiabetic activity of its ingredients: leaves of M. koenigii , cloves of A. sativum , P. nigrum , and their isolated compounds [ 4 – 9 ]. Although there is no scientific data on antidiabetic activity of dried fruit rinds of G. quaesita , plants of this genus such as Garcinia pedunculata, Garcinia indica , and Garcinia xanthochymus have been reported for their significant antidiabetic activities in vivo [ 10 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Acute and Subchronic Toxicity Profile of a Polyherbal Drug Used in Sri Lankan Traditional Medicine

Liyanagamage

Jayasinghe

Attanayake

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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A polyherbal drug composed of leaves of Murraya koenigii L. Spreng, cloves of Allium sativum L., fruits of Garcinia quaesita Pierre, and seeds of Piper nigrum L. is a popular drug which has been used by indigenous practitioners in Sri Lanka for the treatment of diabetes mellitus and dyslipidemia. The acute toxicity assessment was conducted, following a single oral dose of 0.25–2.0 g/kg in healthy rats, and rats were observed up to 14 days. The hot water extract (1.0 g/kg) and the water : acetone extract (0.5, 1.0, and 1.5 g/kg) were administered to Wistar rats for 28 days in the subchronic study. Hypoglycemic and antihyperglycemic activities (dose response studies) of cold water, hot water, and water : acetone extracts of the polyherbal mixture were evaluated at the doses of 0.5, 1.0, and 1.5 g/kg in healthy and streptozotocin-induced diabetic rats (70 mg/kg, ip), respectively. Acute toxicity study showed that the polyherbal drug did not cause any change in animals throughout the experimental period of 14 days. The administration of the hot water extract and the water : acetone extract of the polyherbal drug for 28 days did not produce changes in the selected biochemical and hematological parameters in Wistar rats (p > 0.05). The histological assessment corroborated the biochemical findings with no significant treatment-related changes in the kidney and liver. The treatment of polyherbal drug significantly lowered the serum glucose concentration compared to the diabetic control rats (p < 0.05) while it did not lead to a severe reduction of glucose concentration in healthy rats. The hot water and water : acetone extracts of the polyherbal drug showed a statistically significant improvement on total area under the glucose tolerance curve in diabetic rats (p < 0.05), reflecting dose-dependent antihyperglycemic effects of the drug. Based on the results, we conclude that the aforementioned antidiabetic polyherbal remedy is free of toxic/adverse effects at the equivalent human therapeutic dose in healthy Wistar rats and would be a safe therapeutic agent for long-term treatments.

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Recent Progress for the Utilization of Curcuma longa, Piper nigrum and Phoenix dactylifera Seeds against Type 2 Diabetes

Cited by 19 publications

References 30 publications

Docking-based virtual screening in search for natural PTP1B inhibitors in treating type-2 diabetes mellitus and obesity

Docking-based virtual screening in search for natural PTP1B inhibitors in treating type-2 diabetes mellitus and obesity

The Benefits of Curcumin in Various Diseases and the Extension of Its Application Through Various Technological Approaches

Acute and Subchronic Toxicity Profile of a Polyherbal Drug Used in Sri Lankan Traditional Medicine

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