The antiepileptic effect of Centella asiatica on the activities of Na + /K + , Mg 2+ and Ca 2+ -ATPases in rat brain during pentylenetetrazol-induced epilepsy

Visweswari, G; Prasad, Kanchi Siva; Valluru, Lokanatha; Rajendra, Wudayagiri

doi:10.4103/0253-7613.64504

Cited by 21 publications

(7 citation statements)

References 29 publications

(32 reference statements)

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“…The neuroprotective effects of Centella asiatica have been well documented [20, 61-64], yet these effects have usually been attributed to the bioactive triterpenes (asiatic acid, madecassic acid, asiaticoside, madacassoside) present in the plant. We previously reported that our original extract of CAW does not contain these triterpenes [18].…”

Section: Discussionmentioning

confidence: 99%

Caffeoylquinic Acids in Centella asiatica Protect against Amyloid-β Toxicity

Gray

Morré

Kelley

et al. 2014

JAD

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The accumulation of β-amyloid (Aβ) is a hallmark of Alzheimer’s disease and is known to result in neurotoxicity both in vivo and in vitro. We previously demonstrated that treatment with the water extract of Centella asiatica (CAW) improves learning and memory deficits in Tg2576 mice, an animal model of Aβ accumulation. However the active compounds in CAW remain unknown. Here we used two in vitro models of Aβ toxicity to confirm this neuroprotective effect, and identify several active constituents of the CAW extract. CAW reduced Aβ-induced cell death and attenuated Aβ-induced changes in tau expression and phosphorylation in both the MC65 and SH-SY5Y neuroblastoma cell lines. We confirmed and quantified the presence of several mono- and dicaffeoylquinic acids (CQAs) in CAW using chromatographic separation coupled to mass spectrometry and ultraviolet spectroscopy. Multiple dicaffeoylquinic acids showed efficacy in protecting MC65 cells against Aβ-induced cytotoxicity. Isochlorogenic acid A and 1,5-dicaffeoylquinic acid were found to be the most abundant CQAs in CAW, and the most active in protecting MC65 cells from Aβ-induced cell death. Both compounds showed neuroprotective activity in MC65 and SH-SY5Y cells at concentrations comparable to their levels in CAW. Each compound not only mitigated Aβ-induced cell death, but was able to attenuate Aβ-induced alterations in tau expression and phosphorylation in both cell lines, as seen with CAW. These data suggest that CQAs are active neuroprotective components in CAW, and therefore are important markers for future studies on CAW standardization, bioavailability and dosing.

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Section: Discussionmentioning

confidence: 99%

Caffeoylquinic Acids in Centella asiatica Protect against Amyloid-β Toxicity

Gray

Morré

Kelley

et al. 2014

JAD

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“…In another study [ 74 ], De Lucia et al reported anticonvulsant and sedative activities of the hydroalcoholic extract of C. asiatica in rats using elevated-plus labyrinth and PTZ-induced convulsion models, and the extract was also shown to exert low toxicity by chronic application with the LD 50 value of 675 mg/kg (b.w.). Anticonvulsant activity of the hexane, chloroform, ethyl acetate, water, and n -butanol extracts prepared from C. asiatica was determined using PTZ-induced convulsion model in male Wistar rats, and effect of the extracts was also searched on Na + /K + , Mg 2+ , and Ca 2+ -ATPase activity [ 75 ]. The results pointed out to an increase in activity of three types of ATPases in the extract-administered groups accompanied by anticonvulsant activity.…”

Section: Neuroprotective Activity Of C Asiaticamentioning

confidence: 99%

Centella asiatica(L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential

Orhan

2012

Evidence-Based Complementary and Alternative Medicine

188

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This paper covers the studies relevant to neuroprotective activity of Centella asiatica (L.) Urban, also known as “Gotu Kola.” The plant is native to the Southeast Asia and has been used traditionally as brain tonic in ayurvedic medicine. The neuroprotective effect of C. asiatica has been searched using the key words “Centella, Centella asiatica, gotu kola, Asiatic pennywort, neuroprotection, and memory” through the electronic databases including Sciencedirect, Web of Science, Scopus, Pubmed, and Google Scholar. According to the literature survey, C. asiatica (gotu kola) has been reported to have a comprehensive neuroprotection by different modes of action such as enzyme inhibition, prevention of amyloid plaque formation in Alzheimer's disease, dopamine neurotoxicity in Parkinson's disease, and decreasing oxidative stress. Therefore, C. asiatica could be suggested to be a desired phytopharmaceutical with neuroprotective effect emerged from traditional medicine.

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“…[ 6 ] Anti seizure activity may result from direct or indirect modulation of ATPase activity. [ 7 ] Centella asiatica inhibits the memory impairment induced by scopolamine through the inhibition of AChE. [ 8 ] BR-16A (Mentat), a formulation containing Centella asiatica proved for its antistress effects.…”

Section: Introductionmentioning

confidence: 99%

Nootropic herbs (Medhya Rasayana) in Ayurveda: An update

Kulkarni¹,

Girish²,

Kumar³

2012

Phcog Rev

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Cognitive deficits that present with many of neuropsychiatric conditions and/or alone as developmental deficit demand use of nootropics to boost cognitive abilities. Recently there is a tremendous urge to explore medicinal plants globally for improving cognitive function owing to their less adverse effects. Ayurveda provides a list of herbs known for nootropic activity as well as their multi-dimensional utility in various conditions. Present paper is a review to update knowledge on pharmacological properties, major chemical constituents, therapeutic actions, preclinical studies, safety and possible mode of action of the selected herbs from ayurvedic pharmacopoeia. Concurrently, it opens up for further research and standardization on nootropic herbs

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The antiepileptic effect of Centella asiatica on the activities of Na⁺ /K⁺ , Mg²⁺ and Ca²⁺ -ATPases in rat brain during pentylenetetrazol-induced epilepsy

Cited by 21 publications

References 29 publications

Caffeoylquinic Acids in Centella asiatica Protect against Amyloid-β Toxicity

Caffeoylquinic Acids in Centella asiatica Protect against Amyloid-β Toxicity

Centella asiatica(L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential

Nootropic herbs (Medhya Rasayana) in Ayurveda: An update

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