The Antidiabetic Effect of Low Doses ofMoringa oleiferaLam. Seeds on Streptozotocin Induced Diabetes and Diabetic Nephropathy in Male Rats

Abstract

The antidiabetic activity of two low doses of Moringa seed powder (50 and 100 mg/kg body weight, in the diet) on streptozotocin (STZ) induced diabetes male rats was investigated. Forty rats were divided into four groups. The diabetic positive control (STZ treated) group showed increased lipid peroxide, increased IL-6, and decreased antioxidant enzyme in the serum and kidney tissue homogenate compared with that of the negative control group. Immunoglobulins (IgA, IgG), fasting blood sugar, and glycosylated hemoglobin (HbA1c) were also increased as a result of diabetes in G2 rats. Moreover albumin was decreased, and liver enzymes and α-amylase were not affected. In addition, the renal functions and potassium and sodium levels in G2 were increased as a sign of diabetic nephropathy. Urine analysis showed also glucosuria and increased potassium, sodium, creatinine, uric acid, and albumin levels. Kidney and pancreas tissues showed also pathological alteration compared to the negative control group. Treating the diabetic rats with 50 or 100 mg Moringa seeds powder/kg body weight in G3 and G4, respectively, ameliorated the levels of all these parameters approaching the negative control values and restored the normal histology of both kidney and pancreas compared with that of the diabetic positive control group.

Thymoquinone Improves Anti-Diabetic Activity of Metformin in Streptozotocin-Induced Diabetic Male Rats

“…Oxygen free radicals could react with polyunsaturated fatty acids which lead to lipid peroxidation [51]. In our investigation STZ-diabetic rats showed approximately 4-folds increasing in lipid peroxidation level ( These results are in agreement with previous investigations [52][53] and may be attributed to the fact that the elevated generation of free radicals resulting in the consumption of anti-oxidant defense components which may lead to disruption of cellular functions and oxidative damage to membranes and may enhance susceptibility to lipid peroxidation [54,55]. On the other hand, the combined treatment with TQ and MET improved MDA and TAC and closely restored them to their normal levels.…”

Salvadora persica leaf aqueous extract attenuates hyperglycemia and hyperlipidemia in alloxan induced diabetic male rats

“…To achieve the objective of this study, diabetes was induced in male rats by the intraperitoneal injection of alloxan according to Dash et al [12] and two doses of leaf aqueous extract were used in treating the alloxan diabetic rats for 28 d. In this study, induction of diabetes damaged insulin secreting β-pancreatic cells, reduces the endogenous insulin release and lowers the intake of glucose by the cells which leads to increase blood sugar level and hemoglobin A1c [36][37][38]. The serum alpha-amylase which is considered as an indication of proper pancreatic function [39,40] was also decreased as a result of diabetes and nearly restored its normal levels by treating with S. persica leaf aqueous extract.…”

“…The serum alpha-amylase which is considered as an indication of proper pancreatic function [39,40] was also decreased as a result of diabetes and nearly restored its normal levels by treating with S. persica leaf aqueous extract. In addition, the immunoglobulin's (IgG, IgA and IgM) levels were increased by diabetes [38,41] and they were decreased with the administration of the aqueous extract of S. persica to the alloxan induced diabetic rats in G3 and G4 for 4 weeks. This result is consistent with recent studies by Deepti et al [42] who reported that there was a positive correlation between the two parameters elevated HbA1c and Immunoglobulin level.…”

Phytochemicals, Management of Diabetic Peripheral Neuropathy, Experimental Evidences

“…The administration of 50-100 mg MO seed powder/kg body weight to diabetic rats has been reported to ameliorate DPN and to restore the normal histology of both kidney and pancreas [26].…”