The antidepressant-like effects of Aloysia polystachya (Griseb.) Moldenke (Verbenaceae) in mice

Hellión-Ibarrola, M.C.; Ibarrola, D.A.; Montalbetti, Y.; Kennedy, María L.; Heinichen, O.; Campuzano, M.; Ferro, Esteban; Alvarenga, Nelson; Tortoriello, Jaime; Lima, Thereza Christina Monteiro de; Mora, Sergio

doi:10.1016/j.phymed.2007.11.018

Cited by 33 publications

(26 citation statements)

References 14 publications

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“…The immobility time has been shown to be reduced by treatment with antidepressant drugs [24]. Because the pharmacotherapy of depression typically requires chronic drug treatment to obtain a full response in terms of antidepressant effect, it is critical to perform repeated treatments in the FST rat model [25]. …”

Section: Discussionmentioning

confidence: 99%

Anxiolytic and Antidepressant-Like Effects of the Aqueous Extract ofAlafia multifloraStem Barks in Rodents

Foyet

Tsala

Bouba

et al. 2012

Advances in Pharmacological Sciences

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The present study examined the anxiolytic and antidepressant effects of the aqueous extract of Alafia multiflora Stapf (AM) stem barks (150 and 300 mg/kg, 7 days administration) on rats and mice, using experimental paradigms of anxiety and depression. In the open field, the aqueous extract increased significantly the number of center square crossed and the time spent at the center of the field as well as the rearing time, while the grooming time was reduced significantly. In the elevated plus maze, the aqueous extract increased the time spent and the number of entries in the open arms. All these effects were also completely reversed by flumazenil, an antagonist of benzodiazepine receptors and pindolol a β-adrenoceptors blocker/5-HT 1A/1B receptor antagonist. The time spent in the light compartment, the latency time, and the number of the light-dark transitions increased significantly in the light/dark exploration test after the treatment with AM. The extract was able to reduce significantly the immobility time and increase swimming as well as climbing duration. Taken together, the present work evidenced anxiolytic effects of the aqueous extract of AM that might involve an action on benzodiazepine-type receptors and an antidepressant effect where noradrenergic mechanisms will probably play a role.

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Section: Discussionmentioning

confidence: 99%

Anxiolytic and Antidepressant-Like Effects of the Aqueous Extract ofAlafia multifloraStem Barks in Rodents

Foyet

Tsala

Bouba

et al. 2012

Advances in Pharmacological Sciences

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“…In spite of its wide use and the local experiences for cultivation (Burdyn et al, 2006) there were not studies about its gastrointestinal properties. Nevertheless, there were described anxiolytic and antidepressant effects of A. polystachya (Mora et al, 2005;Hellion-Ibarrola et al, 2008). Also, it has been described the presence of (-)-carvone in the essential oil of A. polystachya (Werdin-González et al, 2010), which was related to antispasmodic effect of Mentha genus (de Goncalves et al, 2008) as well as other terpenic compounds.…”

Section: Introductionmentioning

confidence: 99%

Antispasmodic effects of Aloysia polystachya and A. gratissima tinctures and extracts are due to non-competitive inhibition of intestinal contractility induced by acethylcholine and calcium

Consolini¹,

Berardi²,

Rosella³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The antispasmodic effects of acqueous extracts (AE) and tinctures (T) of Aloysia polystachya (Griseb.) Moldenke and Aloysia gratissima (Gillies & Hook.) Tronc., Verbenaceae, were studied on rat isolated ileum and duodenum. These plants are used for gastrointestinal disorders and as eupeptic in South America. Both AE non-competitively inhibited the dose-response curves (DRC) of ACh and the DRC of Ca 2+ in high-[K + ] o , as well as the T. The T of A. polystachya and A. gratissima respectively inhibited the ACh-DRC at the IC50 of 3.15±0.57 and 6.46±2.28 mg leaves/mL. The Ca 2+ -antagonist activity of both T occurred with IC50 respectively similar to those of the ACh-DRC, and was potentiated by the depolarization produced by 10 mM TEA, a blocker of K + -channels. The spasmolytic effect of T does not involve DA release and binding to D2, since it was not reduced by 10 µM metoclopramide. Also, T induced dose-dependent relaxation on the tonic contracture produced by high-[K + ] o and ACh. By TLC there were detected in the leaves the presence of carvone, and flavonoids such as quercetin and hesperidin. By HPLC there were not found vitexin nor isovitexin, identified in A. citriodora. The monoterpene (-)-carvone non-competitively inhibited the ACh-DRC (pD´2 of 4.0±0.1) and the DRC of Ca 2+ (pD´2 of 3.86±0.19), suggesting that the Ca 2+ -influx blockade is the mechanism of its antispasmodic effect. Results suggest that the antispasmodic effect of A. polystachya and A. gratissima are mostly explained by the non-competitive blockade of Ca +2 influx. It could be associated to the presence of flavonoids, and in the tinctures to some spasmolytic components of the essential oil such as carvone.

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“…Besides that, it was demonstrated that PFE exhibits low toxicity, no lethality, was well tolerated, did not induce significant changes in several behavioural and physiological parameters and is devoid of any hypnosedative activity, when administered to mice [15]. Recently, the antidepressant action of some herbal medicines has been reported focusing on polyphenols as their major component [3] [4] [14]. The edible part of pomegranate is rich in anthocyanins thus; the major class of phytochemical present in pomegranate is the polyphenols.…”

Section: Discussionmentioning

confidence: 99%

“…This test was performed according to the procedure described by Porsolt et al [11]- [13], with slight modifications [14]. Briefly, 1 h after dosing, the animals were individually forced to swim in a transparent glass vessel (25 cm high, 15 cm in diameter) filled with (12.5 cm high) water at 21˚C -24˚C.…”

Section: Behavioral Testsmentioning

confidence: 99%

The Antidepressant-Like Effects of <i>Punica granatum</i> (Pomegranate) Extract in Mice

Jahromy¹,

Khakpour²,

Khorgami³

2014

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The aim of the present work is to evaluate the putative antidepressant-like effects of pomegranate fruit extract including seeds (PFE) on the performance of male mice in the forced swimming test (FST), after acute administration, after short-term treatment (7 days) and, after repeated administration in a 24-h period (24, 12 and 1 h before swimming test). A single dose (20 ml/kg p.o.) of PFE, in male mice provoked a significant reduction of the immobility time. Such effect was also observed with short-term treatment (7 days) with doses of 1 and 10 ml/kg/day of PFE. Moreover, it was noted that there were important differences in the onset of the antidepressant-like effect in the FST, depending on the modality of treatment with PFE. Both efficacy and potency were higher when repeated administration of PFE was used, and surprisingly the dose of 10 ml/kg (24, 12 and 1 h before swimming test) was as effective as Fluoxetine. In the same way, the short term administration (7 days) improved significantly efficacy and potency of the PFE in comparison to a single dose treatment. These results indicate an antidepressant-like profile of action for PFE which deserves further research.

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The antidepressant-like effects of Aloysia polystachya (Griseb.) Moldenke (Verbenaceae) in mice

Cited by 33 publications

References 14 publications

Anxiolytic and Antidepressant-Like Effects of the Aqueous Extract ofAlafia multifloraStem Barks in Rodents

Anxiolytic and Antidepressant-Like Effects of the Aqueous Extract ofAlafia multifloraStem Barks in Rodents

Antispasmodic effects of Aloysia polystachya and A. gratissima tinctures and extracts are due to non-competitive inhibition of intestinal contractility induced by acethylcholine and calcium

The Antidepressant-Like Effects of <i>Punica granatum</i> (Pomegranate) Extract in Mice

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The antidepressant-like effects of Aloysia polystachya (Griseb.) Moldenke (Verbenaceae) in mice

Cited by 33 publications

References 14 publications

Anxiolytic and Antidepressant-Like Effects of the Aqueous Extract ofAlafia multifloraStem Barks in Rodents

Anxiolytic and Antidepressant-Like Effects of the Aqueous Extract ofAlafia multifloraStem Barks in Rodents

Antispasmodic effects of Aloysia polystachya and A. gratissima tinctures and extracts are due to non-competitive inhibition of intestinal contractility induced by acethylcholine and calcium

The Antidepressant-Like Effects of &lt;i&gt;Punica granatum&lt;/i&gt; (Pomegranate) Extract in Mice

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The Antidepressant-Like Effects of <i>Punica granatum</i> (Pomegranate) Extract in Mice