Anxiolytic and Antidepressant-Like Effects of the Aqueous Extract of<i>Alafia multiflora</i>Stem Barks in Rodents

Foyet, Harquin Simplice; Tsala, David Emery; Bouba, Armand Abdou; Hrițcu, Lucian

doi:10.1155/2012/912041

Cited by 30 publications

(25 citation statements)

References 31 publications

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“…Head-dipping behavior of experimental animals is the main basis of hole board apparatus. If the test animals are sensitive to changes in the emotional state and or in anxiolytic state, head-dipping might have increased [42,43]. Increased head-dipping was observed with chloroform soluble fraction (at both doses level of 200 mg/kg and 400 mg/kg) in respect to other fractions.…”

Section: Discussionmentioning

confidence: 92%

In-vivo and in-vitro evaluation of pharmacological activities of Ardisia solanacea leaf extract

et al. 2019

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Background: The Bangladeshi rural and hilly areas people have long tradition to use various medicinal plants for treating different diseases. That's why, the crude methanolic leaf extract of Ardisia solanacea with its different fractions (petroleum ether, carbon tetrachloride, n-hexane and chloroform fractions) were subjected to investigate bioactivities in swiss albino mice; namely analgesic, CNS, and Oral hypoglycemic activities, while in-vitro evaluation of cytotoxicity. Methods: Central nervous system activity was investigated by various method such as Elevated plus maze, Hole board, Hole cross and Open field test apparatus. Analgesic activity was evaluated by both acetic acid induced and tail immersion method. Hypoglycemic activity was evaluated by oral glucose tolerance test and cytotoxicity was evaluated by Brine shrimp lethality bioassay. Results: In CNS activity, among others fractions, ASCF fraction produced a significant anxiolytic activity in both elevated plus maze and Hole board test. During open-field test almost all the fractions of A. solanacea leaves extract display decreased locomotor activities that indicates significant sedative activity. The ASME and ASCF showed significant peripheral analgesic activity at a dose of 200 mg/kg and 400 mg/kg body weight (p < 0.05). In tail immersion method, among others extracts chloroform fractions exhibited significant (p < 0.05) elongation of reaction time 30 min after oral dose of 200 and 400 mg/kg body weight respectively. The methanolic and n-hexane extracts reduced blood glucose level significantly after 90 min with value of 53.94% and 48.15% respectively (p < 0.05). In case of cytotoxicity activity, among other fractions carbon tetrachloride fraction showed lowest LC 50 values. Conclusions: From the above results, it is clear that different fractions of A. solanacea showed significant pharmacological potentiality in different in-vitro and in-vivo study model. So, it will be very much possible source for an isolating lead compound for curing the numerous disorders.

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Section: Discussionmentioning

confidence: 92%

In-vivo and in-vitro evaluation of pharmacological activities of Ardisia solanacea leaf extract

et al. 2019

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“…The exposure of mice to bright unknown spaces produces fear and anxiety responses in the animals changing their behavior and locomotive activity 13,14 . The number of crossed lines measures locomotor activity, and it is used to measure the sedative activity in mice 15,16 roughly. Foyet and colleagues define it as horizontal movement.…”

Section: Discussionmentioning

confidence: 99%

Sedative and anxiolytic effect of the methanolic extract of Erythrina edulis Triana ex Micheli in mice

Sarmiento

Saa

Peñaherrera

2018

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The traditional use of medicinal plants and its link with pharmacological studies is essential in order to corroborate the effect scientifically. The present work was an experimental study designed to investigate the sedative and anxiolytic effect of the methanol extract of the leaves of Erythrina edulis. The extract was prepared by percolation. Different concentrations: 500, 250 and 125 mg/kg of the extract and diazepam as a controlled drug were administered intraperitoneally to Swiss CD1 mice for both, sedation and anxiety tests. The sleep enhancement test with pentobarbital and the traction test were used for the sedative activity. Results showed that the extract did not possess sedative activity in any of the administered doses. However, the possibility of an opposite effect was observed as an activation of the central nervous system probably. The anxiolytic activity was evaluated by the open field test and the elevated plus maze test, where a behavior with a low level of anxiety was observed. Altogether, the results suggest that the extract has an anxiolytic activity without sedation, which supports traditional use. But, its responses are not dose-dependent, and its mechanism of action is unknown. Besides, toxicity assay was performed in Artemia salina nauplii, resulting in a lethal concentration 50 of 16.570 ug/mL corresponding to zero toxicity. Finally, the phytochemical analysis of the extract revealed the presence of flavonoids (flavonols, flavones and phenolic carboxylic acids), anthrones, anthranols, terpenes (mono and sesquiterpenes), saponins and hydrolysable tannins.

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“…A wide range of plant-derived flavonoids, terpenes, can cross the bloodbrain barrier and are able to influence brain function [95] such as the modulation of the function of inotropic GABA receptors. Due to the presence of flavonoids in the extract of A. Multifora and its higher antioxidant activities, it is presumed that this plant might have pharmacological effects at the level of the central nervous system including antidepressant activity [96].…”

Section: Alafia Multiforamentioning

confidence: 99%

A Review Study on the Traditional Plants has Potential Antidepressant Property

Rahman¹

2017

MOJCSR

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DiscussionThis review includes detailed description of antidepressant activity of 21 medicinal plants whose roots, leaves, fruits extracts were used to evaluate the activity from various research articles.The tests employed for antidepressant activity includes HBT, FST, TST, OFT, EPMT, and MACT using rotarod and THB. These tests are employed with slight modification from original method, keeping basic concept same. HBTExploratory behaviour of rodents such as mice is evaluated using hole board test. The floor of the apparatus has regularly arranged holes. The animal is placed in the arena. Both frequency and duration of spontaneous elicited hole-poking behavior are then measured during a short period of time. This test also provides a simple method for assessing anxious response of a rodent to an unfamiliar environment. The use of the hole-board in this perspective relies on the hypothesis that the behavior of animals exposed to a novel situation results from competition AbstractDepression refers to a state of low mood and aversion to activity characterized by depressed mood, loss of interest, reduced energy and concentration. The reasons for the disease include stimulation of MAO-A, inhibition of NA and 5-HT. Symptoms include the diminished interest of pleasure, feelings of worthlessness or inappropriate guilt, a decrease in appetite and libido, insomnia, and recurrent thoughts of death or suicide. There are plenty of synthetic drugs used to treat depression but not enough blissful for patients, moreover, these synthetic drugs have potential side effects. After decades of serious obsession with the modern medicinal system, people have started looking at the ancient healing systems like Ayurveda, Siddha, and Unani. Many scientists are researching plant material for treating this disorder and there are lots of publications on it. But this is not sufficient for treating depression; further outcome should come into light that's the purpose of our review.

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Anxiolytic and Antidepressant-Like Effects of the Aqueous Extract ofAlafia multifloraStem Barks in Rodents

Cited by 30 publications

References 31 publications

In-vivo and in-vitro evaluation of pharmacological activities of Ardisia solanacea leaf extract

In-vivo and in-vitro evaluation of pharmacological activities of Ardisia solanacea leaf extract

Sedative and anxiolytic effect of the methanolic extract of Erythrina edulis Triana ex Micheli in mice

A Review Study on the Traditional Plants has Potential Antidepressant Property

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