The Antidepressant-like Effect of Hyperbrasilol B, A Natural Dimeric Phloroglucinol Derivative is Prevented by Veratrine, a Sensitive-Voltage Na+ Channel Opener

Abstract

This work was carried out in collaboration between all authors. Author FBC contributed with the design of the study; performed the In vivo experiments, statistical analysis an literature searches; wrote the protocol and the first draft of the manuscript. Author SS performed all chemical procedures. Author LGM contributed with In vivo experiments and statistical analysis. Author PMC performed In vitro experiments. Author GVP planned and supervised all chemical experiments. Author CWN planned and supervised all in vitro experiments. Author SMKR designed the whole study, managed the literature searches, statistical analyses and revised the final version of the manuscript. All authors read and approved the final manuscript.

Methylene-bridged dimeric natural products involving one-carbon unit in biosynthesis

“…The results showed that the antidepressant-like effect might be due to the alterations in the sodium ion gradient. 41…”

Cytotoxic and Antibacterial Prenylated Acylphloroglucinols from Hypericum olympicum L.

“…Other pharmacological effects of phloroglucinols include antioxidant, antidepressant, antiviral (including effectiveness against SARS-CoV-19), antinociceptive etc. [ 23 , 27 , 33 , 34 , 35 ].…”