The antidepressant effect of<i>Cynanchum auriculatum</i>in mice

Ji, Cheng-xue; Li, Xinya; Jia, Shaobo; Liu, Li‐Li; Ge, Yong-Chang; Yang, Qing-Xiong; Zhang, Jianjun

doi:10.3109/13880209.2012.656848

Cited by 17 publications

(6 citation statements)

References 23 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have confirmed the open field to be a classic animal model to evaluate spontaneous and general activity of animals [32,33]. Our interpretation is therefore in line with other studies attributing reduced immobility times in the forced swim test to antidepressant activity of the drug under investigation [34,35]. …”

Section: Discussionsupporting

confidence: 90%

Antidepressant-like effects of the aqueous macerate of the bulb of Gladiolus dalenii Van Geel (Iridaceae) in a rat model of epilepsy-associated depression

Ngoupaye

Bum

Daniels

2013

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundIn Cameroonian traditional medicine various extracts of Gladiolus dalenii Van Geel (Iridaceae) have been used as a cure for various ailments that include headaches, digestive problems, muscle and joint aches, and some central nervous system disorders such as epilepsy, schizophrenia and mood disorders. Owning to this background, the aim of the study was to investigate whether an aqueous macerate of the bulb of Gladiolus dalenii has any antidepressant activity focusing specifically on depression-like behaviours associated with epilepsy.MethodWe used the combined administration of atropine and pilocarpine to rats as our animal model of epilepsy. The forced swim test and spontaneous locomotor activity in the open field test were the two tools used to assess the presence of depression-like behaviour in epileptic and control animals. The following depression-related parameters were determined: plasma ACTH, plasma corticosterone, adrenal gland weight and hippocampal levels of brain-derived neurotrophic factor (BDNF). The effects of Gladiolus dalenii were compared to that of fluoxetine.ResultsOur results showed that we had a valid animal model of epilepsy-induced depression as all 3 measures of construct, predictive and face validity were satisfied. The data indicated that Gladiolus dalenii significantly reduced the immobility times in the forced swim test and the locomotor activity as assessed in the open field. A similar pattern was observed when the HPA axis parameters were analysed. Gladiolus dalenii significantly reduced the levels of ACTH, corticosterone, but not the adrenal gland weight. Gladiolus dalenii significantly increased the level of BDNF in the hippocampus. In all parameters measured the effects of Gladiolus dalenii were significantly greater than those of fluoxetine.ConclusionThe results show that Gladiolus dalenii has antidepressant-like properties similar to those of fluoxetine in epilepsy-associated depressive states. The antidepressant activity of Gladiolus dalenii is likely to be mediated by restoring the activity of the HPA axis and increasing the levels of BDNF in the hippocampus.

show abstract

Section: Discussionsupporting

confidence: 90%

Antidepressant-like effects of the aqueous macerate of the bulb of Gladiolus dalenii Van Geel (Iridaceae) in a rat model of epilepsy-associated depression

Ngoupaye

Bum

Daniels

2013

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…Modern phytochemical and pharmacological studies have demonstrated that C-21 steroidal glycosides are the major active components of Baishouwu ( 2 , 3 ). The total C-21 steroidal glycosides (TCSGs), isolated from Baishouwu, possess various pharmacological activities, including antitumor ( 4 – 11 ), aging-attenuating ( 12 ), free radical-scavenging ( 13 ), immunity-enhancing ( 14 ), depression-reducing ( 15 ) and fungus-suppressing ( 16 ) activities. Recently, it has been reported that the C-21 steroidal glycosides isolated from Baishouwu exhibit notable hepatoprotective effects in vivo ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

Total C-21 steroidal glycosides, isolated from the root tuber of Cynanchum�auriculatum Royle ex Wight, attenuate hydrogen peroxide-induced oxidative injury and inflammation in L02 cells

Wang

Meng

et al. 2018

Int J Mol Med

View full text Add to dashboard Cite

Oxidative stress plays an important role in the pathology of liver disorders. Total C-21 steroidal glycosides (TCSGs), isolated from the root tuber of Cynanchum auriculatum Royle ex Wight, have been reported to exert numerous effects, including liver protective and antioxidant effects. In order to investigate the potential mechanisms underlying the protective effects of TCSGs on liver function, the present study used the human normal liver cell line, L02, to evaluate the effects of TCSGs on hydrogen peroxide (H2O2)-induced oxidative injury and inflammatory responses. The L02 cells were pretreated with various concentrations of TCSGs, followed by exposure to 1.5 mM H2O2. Cell viability was determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-di-phenyltetrazolium bromide (MTT) assay. The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and nitric oxide (NO) were measured using colorimetric assays. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and the production of malondialdehyde (MDA) were also determined. Intracellular reactive oxygen species (ROS) levels were detected using a fluorescent probe. H2O2-induced oxidative toxicity was attenuated following treatment with TCSGs, as indicated by the increase in cell viability, the decreased levels of ALT, AST, LDH, NO, MDA and ROS, and the increased activities of SOD, CAT and GSH-Px. To further explore the possible mechanisms of action of TCSGs, the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-κB (NF)-κB pathways were examined. The results revealed that treatment with TCSGs markedly induced Nrf2 nuclear translocation and upregulated the expression of heme oxygenase-1 (HO-1) in the L02 cells damaged by H2O2. In addition, pretreatment with TCSGs inhibited the NF-κB signaling pathway by blocking the degradation of the inhibitor of nuclear factor κBα (IκBα), thereby reducing the expression and nuclear translocation of NF-κB, as well as reducing the expression of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2). On the whole, the findings of this study demonstrate that TCSGs can protect L02 cells against H2O2-induced oxidative toxicity and inflammatory injury by increasing the expression of Nrf2 and HO-1, mediated by the NF-κB signaling pathway.

show abstract

“…The total glycoside-fraction of Cynanchum auriculatum was also tested with the FST, TST, and LAT. In addition, the authors tested for the inhibition of 5-HT reuptake in rat brain synaptosomes to conclude that the antidepressant-like effects are due to the inhibitory effect on serotonin reuptake [172].…”

Section: Experimental Studies In Animals or Cellsmentioning

confidence: 99%

Untitled

2021

Planta Med

View full text Add to dashboard Cite

Depression is a syndrome characterized by profound sadness and a global inhibition of psychic functions. It is also the most common mental alteration among the general population, affecting about 322 million people worldwide [1]. It is estimated that the number of people living with depression increased by roughly 18 % between 2005 and 2015, making it one of the great epidemics of the 21st century [2]. Depression manifests itself as sadness, hopelessness, apathy, and anhedonia, with feelings of worthless-

show abstract

The antidepressant effect ofCynanchum auriculatumin mice

Cited by 17 publications

References 23 publications

Antidepressant-like effects of the aqueous macerate of the bulb of Gladiolus dalenii Van Geel (Iridaceae) in a rat model of epilepsy-associated depression

Antidepressant-like effects of the aqueous macerate of the bulb of Gladiolus dalenii Van Geel (Iridaceae) in a rat model of epilepsy-associated depression

Total C-21 steroidal glycosides, isolated from the root tuber of Cynanchum�auriculatum Royle ex Wight, attenuate hydrogen peroxide-induced oxidative injury and inflammation in L02 cells

Untitled

Contact Info

Product

Resources

About