Antidepressant-like effects of the aqueous macerate of the bulb of Gladiolus dalenii Van Geel (Iridaceae) in a rat model of epilepsy-associated depression

Ngoupaye, Gwladys Temkou; Bum, Elisabeth Ngo; Daniels, Willie M. U.

doi:10.1186/1472-6882-13-272

Cited by 22 publications

(15 citation statements)

References 36 publications

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“…17 Duration of immobility is the indicator behaviour observed in both tests. 18 The methanol stem bark extract of A. digitata (MEAD) significantly decreased the immobility time indicating its antidepressant activity when assessed in FST and in TST. In addition, the extract MEAD significantly (P ≤ 0.001) increased swimming time but not climbing behaviour, unlike the standard drug imipramine which significantly (P ≤ 0.001) increased climbing behaviour with no effect on the swimming time ( Figure 3).…”

Section: Resultsmentioning

confidence: 99%

Antidepressant Effect of Methanol Stem Bark Extract of Adansonia digitata L. (Malvaceae) in Mice

Shehu¹,

Magaji²,

Ya’u³

et al. 2018

TJNPR

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Phytochemical investigation has shown the presence of flavonoids, phytosterols, amino acids, fatty acids, vitamins and minerals. 7 The present study, therefore, is aimed at evaluating the antidepressant activity of the methanol stem bark extract of Adansonia digitata.Adansonia digitata (Malvaceae) is a plant native to Africa with all its parts used extensively since ancient times in traditional medicine for different purposes including psychiatric disorders. The plant has been used ethnomedicinally as a remedy for depression. The aim of the study was to investigate the antidepressant activity of the methanol stem bark extract of A. digitata. Phytochemical screening and acute oral toxicity (LD50) study were done using standard procedures. Antidepressant activity of the extract (250-1000 mg/kg) was evaluated using tail suspension test (TST) and forced swim test (FST) in mice. Tests for motor co-ordination deficit and stimulant activity were evaluated using beam walking assay (BWA) and open field test (OFT), respectively. The effect of the methanol stem bark extract of A. digitata was tested using the novel object recognition task (NORT). The phytochemical screening of the extract showed the presence of steroids, tannins, flavonoids, alkaloids and saponins. The LD50 was found to be greater than 5000 mg/kg orally. The extract significantly (P < 0.01) and dose-dependently decreased the duration of immobility in the TST and FST. There was no significant change in the number of lines crossed and on the number of foot slips in the OFT and BWA, respectively. The extract showed no significant effect on cognition in the NORT. In conclusion, the methanol stem bark extract of A. digitata possesses antidepressant activity.

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Section: Resultsmentioning

confidence: 99%

Antidepressant Effect of Methanol Stem Bark Extract of Adansonia digitata L. (Malvaceae) in Mice

Shehu¹,

Magaji²,

Ya’u³

et al. 2018

TJNPR

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“…However, the resulting adverse effects associated with these agents have limited their use [12]. Despite the availability of different approaches for the discovery of therapeutics, natural plant products still remain one of the best sources of new structural types [13]. Moreover, the World Health Organization has estimated that in developing countries, medicinal plants contribute significantly to primary health [13, 14].…”

Section: Introductionmentioning

confidence: 99%

“…Despite the availability of different approaches for the discovery of therapeutics, natural plant products still remain one of the best sources of new structural types [13]. Moreover, the World Health Organization has estimated that in developing countries, medicinal plants contribute significantly to primary health [13, 14]. Therefore, it is worthwhile to explore the utility of medicinal plants for the treatment of various cognitive disorders.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective and Antiamnesic Effects ofMitragyna inermisWilld (Rubiaceae) on Scopolamine-Induced Memory Impairment in Mice

Pahaye

Bum

Taïwé

et al. 2017

Behavioural Neurology

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Aim. To assess memory improvement and neuroprotective and antioxidant effects of Mitragyna inermis (M. inermis) leaf decoction on the central nervous system. Methodology. Leaf decoction of M. inermis was tested on learning and memory in normal and scopolamine-induced cognitive impairment in mice using memory behavioral tests such as the Morris water maze, object recognition task, and elevated plus maze. Oxidative stress enzymes—catalase, superoxide dismutase, and the thiobarbituric acid reactive substance, a product of lipid peroxidation—were quantified. In each test, mice 18 to 25 g were divided into groups of 5. Results. The extract reversed the effects of scopolamine in mice. The extract significantly increased discrimination index in the object recognition task test and inflexion ratio in the elevated plus maze test. The times spent in target quadrant in MWM increased while the transfer latency decreased in mice treated by M. inermis at the dose of 196.5 mg/kg. The activity levels of superoxide dismutase and catalase were significantly increased, whereas the thiobarbituric acid reactive substance was significantly decreased after 8 consecutive days of treatment with M. inermis at the dose of 393 mg/kg. Conclusion. These results suggest that M. inermis leaf extract possess potential antiamnesic effects.

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“…Several plants have proven anxiolytic-like effects in animal models. For example, Afrormosia laxiflora (Benth) Harms (Fabaceae), Chenopodium ambrosioides Linn (Chenopodiaceae), Microglossa pyrifolia Kuntze (Lam) (Asteraceae), Mimosa pudica Linn (Mimosaceae), Nelsonia canescens (Acanthaceae), and Gladiolus dalenii Van Geel (Iridaceae) ( Ngo Bum et al, 2011 ; Ngoupaye et al, 2013a ; Fotsing et al, 2016 ). G. dalenii is plant of the Iridaceae family generally used in Cameroon pharmacopoeia, especially in the West region to cure various ailments like schizophrenia, depression, and headaches.…”

Section: Introductionmentioning

confidence: 99%

Effects of Gladiolus dalenii on the Stress-Induced Behavioral, Neurochemical, and Reproductive Changes in Rats

et al. 2017

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Gladiolus dalenii is a plant commonly used in many regions of Cameroon as a cure for various diseases like headaches, epilepsy, schizophrenia, and mood disorders. Recent studies have revealed that the aqueous extract of G. dalenii (AEGD) exhibited antidepressant-like properties in rats. Therefore, we hypothesized that the AEGD could protect from the stress-induced behavioral, neurochemical, and reproductive changes in rats. The objective of the present study was to elucidate the effect of the AEGD on behavioral, neurochemical, and reproductive characteristics, using female rats subjected to chronic immobilization stress. The chronic immobilization stress (3 h per day for 28 days) was applied to induce female reproductive and behavioral impairments in rats. The immobilization stress was provoked in rats by putting them separately inside cylindrical restrainers with ventilated doors at ambient temperature. The plant extract was given to rats orally everyday during 28 days, 5 min before induction of stress. On a daily basis, a vaginal smear was made to assess the duration of the different phases of the estrous cycle and at the end of the 28 days of chronic immobilization stress, the rat’s behavior was assessed in the elevated plus maze. They were sacrificed by cervical disruption. The organs were weighed, the ovary histology done, and the biochemical parameters assessed. The findings of this research revealed that G. dalenii increased the entries and the time of open arm exploration in the elevated plus maze. Evaluation of the biochemical parameters levels indicated that there was a significant reduction in the corticosterone, progesterone, and prolactin levels in the G. dalenii aqueous extract treated rats compared to stressed rats whereas the levels of serotonin, triglycerides, adrenaline, cholesterol, glucose estradiol, follicle stimulating hormone and luteinizing hormone were significantly increased in the stressed rats treated with, G. dalenii, diazepam and in co-administration of the plant extract and diazepam treated rats. Moreover stressed rats showed significant changes in estrous cycle phases compared to vehicle control and these changes of the estrous cycle were less in the rats treated with G. dalenii compared to the negative control rats. G. dalenii extract showed antagonizing effects on the stress-induced reproductive, behavioral, and neurochemical changes. These effects could be related to the bioactive molecules and secondary metabolites like alkaloids and flavonoids in the plant.

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Antidepressant-like effects of the aqueous macerate of the bulb of Gladiolus dalenii Van Geel (Iridaceae) in a rat model of epilepsy-associated depression

Cited by 22 publications

References 36 publications

Antidepressant Effect of Methanol Stem Bark Extract of Adansonia digitata L. (Malvaceae) in Mice

Antidepressant Effect of Methanol Stem Bark Extract of Adansonia digitata L. (Malvaceae) in Mice

Neuroprotective and Antiamnesic Effects ofMitragyna inermisWilld (Rubiaceae) on Scopolamine-Induced Memory Impairment in Mice

Effects of Gladiolus dalenii on the Stress-Induced Behavioral, Neurochemical, and Reproductive Changes in Rats

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