The anticancer efficacy of pixantrone-loaded liposomes decorated with sialic acid–octadecylamine conjugate

Dual-ligand modified liposomes provide effective local targeted delivery of lung-cancer drug by antibody and tumor lineage-homing cell-penetrating peptide

“…Recently, active targeted liposomes modified with antibodies or other ligands have attracted researchers’ interest. These liposomes display improved anti-cancer therapeutic efficacy because they bind specifically with the over-expressed receptors of tumor cells (Al-Ahmady et al., 2014 ; Dicheva et al., 2014 ; She et al., 2014 ). However, they are not being used in clinical applications because (a) binding-site barriers prevent them from penetrating deeply into tumors, and (b) the dynamic and heterogeneous nature of tumor cells prevents them from efficient binding (Cai et al., 2014b ).…”

Using hyaluronic acid-functionalized pH stimuli-responsive mesoporous silica nanoparticles for targeted delivery to CD44-overexpressing cancer cells

“…Many methods have been developed to synthesize pH-responsive MSNs systems and pH-sensitive lipid membrane as drug carriers to deliver drugs and trigger the release of encapsulated drugs in tumor cells, an important role in all drug delivery systems. [14][15][16][17] The pH-sensitive lipid membrane that target tumors are stable at physiological pH values, but are designed to become unstable under acidic conditions, resulting in the release of their drug cargo. 18 Some studies have shown that coated nanoparticles of pH-sensitive lipid membrane can protect the drug and increase the drug concentration, which is favored to decrease systemic toxicity and enhance antitumor activity.…”

“…18 Some studies have shown that coated nanoparticles of pH-sensitive lipid membrane can protect the drug and increase the drug concentration, which is favored to decrease systemic toxicity and enhance antitumor activity. 14,15 Hyaluronic acid (HA) is a kind of functional material that acts as a drug carrier or targeting moiety, which is a natural ligand for cancer cells overexpressing CD44 and that could interact with a CD44 receptor excessively expressed in most tumor cells. 19 HA is one of the major components of vertebrate tissue and body fluid; it interacts with the CD44 receptors that trigger intracellular signals influencing cellular proliferation, differentiation, and migration.…”

Neutrophil-mediated delivery of pixantrone-loaded liposomes decorated with poly(sialic acid)–octadecylamine conjugate for lung cancer treatment

“…A xenograft mice model of S180 tumor in vivo was established by our research group (She et al., 2014 ; Yang et al., 2014 ; Sun et al., 2016 ; Zhang et al., 2016 ; Zhou et al., 2017 ). Briefly, 0.2 mL of S180 cells (1 × 10 7 cells/mL) were subcutaneously injected into the right axillary flank of male Kunming mice on day 0.…”