The antibody repertoire in evolution: Chance, selection, and continuity

Marchalonis, John J.; Adelman, Miranda K.; Schluter, Samuel F.; Ramsland, Paul A.

doi:10.1016/j.dci.2005.06.011

Cited by 28 publications

(20 citation statements)

References 161 publications

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“…The basis for 2) and 3) above could be the same. For example, human V3-23, mouse V H 283 (a V H 2 family gene), and shark V H genes share .80% sequence similarity at the protein level (7,21) and encode BCRs that are polyreactive and recognize bacterial polysaccharides (22). In humans and mice, such Abs are often associated with IgG3 (23,24) and class switch that occurs in the absence of environmental Ag (25,26) and in CD40/CD40L-deficient mice (27).…”

mentioning

confidence: 99%

Antibody Repertoire Development in Fetal and Neonatal Piglets. XI. The Relationship of Variable Heavy Chain Gene Usage and the Genomic Organization of the Variable Heavy Chain Locus

Eguchi-Ogawa

Wertz

Sun

et al. 2010

The Journal of Immunology

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confidence: 99%

Antibody Repertoire Development in Fetal and Neonatal Piglets. XI. The Relationship of Variable Heavy Chain Gene Usage and the Genomic Organization of the Variable Heavy Chain Locus

Eguchi-Ogawa

Wertz

Sun

et al. 2010

The Journal of Immunology

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“…These include the progressive development of the adaptive immune system that becomes superimposed on the innate immune system that developed during fetal life. The transition is ''cushioned'' by passive immunity and germline-encoded pre-adaptive or ''natural'' antibodies that provide protection by recognizing many ubiquitous epitopes on bacterial pathogens [2,3]. Development of adaptive immunity during this period in truly naïve neonates is initiated through stimulation of TLRs and NOD receptors of the innate system by MAMPs (microbial associated molecular patterns) provided by colonizing bacteria which perhaps may do so by causing maturation of APCs [4][5][6].…”

Section: Introductionmentioning

confidence: 98%

The isolator piglet: a model for studying the development of adaptive immunity

Butler

Šinkora

2007

Immunol Res

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The period from late gestation to weaning in neonatal mammals is a critical window when the adaptive immune system develops and replaces the protection temporarily provided by passive immunity and pre-adaptive antibodies. It is also when oral tolerance to dietary antigen and the distinction between commensal and pathogenic gut bacteria becomes established resulting in immune homeostasis. The reproductive biology of swine provides a unique model for distinguishing the effects of different factors on immune development during this critical period because all extrinsic factors are controlled by the experimenter. This chapter reviews this early stage of development and the usefulness of the piglet model for understanding events during this transitional stage. The review also describes the major features of the porcine immune system and the immune stimulatory and dysregulatory factors that act during this period. The value of the model to medical science in such areas as food allergy, organ transplantation, cystic fibrosis and the production of humanized antibodies for immuno-therapy is discussed.

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“…2006) on the antibody repertoire from fish to man. In that same issue Marchalonis et al (2006) summarized antibody evolution as follows: "Overall, antibodies of jawed vertebrates show tremendous individual diversity, but are constructed in incorporating design factors that arose with the evolutionary emergence of the jawed vertebrates and have been conserved through at least 450 million years of evolutionary time". These conclusions would suggest that evolution had "all the time in the world" to develop immune mechanisms that would help to protect young children from severe, often fatal diseases.…”

Section: Our Longtime Search For the "O" Infectious Agents Associatedmentioning

confidence: 99%

The Possible Role of Transplacentally‐Acquired Antibodies to Infectious Agents, With Molecular Mimicry to Nervous System Sialic Acid Epitopes, as Causes of Neuromental Disorders: Prevention and Vaccine Implications

Nahmias

Nahmias²,

Danielsson

2006

Journal of Immunology Research

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Proof of causality of most neuromental disorders (NMD's) is largely unavailable. Lessons from four-decade investigations of the epidemiology, immunology, pathogenesis, prevention and therapy of perinatal infectious agents, which invade directly the nervous system, have led us to propose a new indirect effect hypothesis: maternal transplacentally-acquired antibodies, to agents with epitope molecular mimicry with the developing nervous system, can cross the fetus/infant's blood -nervous system barriers to cause NMD's, clinically manifest years later.Further rationale is provided by relevant evolutionary/developmental (EVO -DEVO) considerations-applicable also to some vaccines. The hypothesis is being tested in: (a) older pregnancy studies with available maternal and newborn sera, and follow-up of the progeny for NMD's; and (b) NMD registry individuals linked to their stored newborn blood spots. Preliminary results support a possible role for schizophrenia of high-tittered antibodies to some agents (toxoplasma, influenza and herpes simplex type 2 virus).A model that includes likely genetic and postnatal influences is schematized and a list of putative agents and factors, based on varying rationales, is tabulated. In case pilot studies are confirmed, the identified agent(s) and antibodies would need to be tested in new prospectively enrolled pregnant women, so as to establish further risk factors leading to possible preventive modalities.

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The antibody repertoire in evolution: Chance, selection, and continuity

Cited by 28 publications

References 161 publications

Antibody Repertoire Development in Fetal and Neonatal Piglets. XI. The Relationship of Variable Heavy Chain Gene Usage and the Genomic Organization of the Variable Heavy Chain Locus

Antibody Repertoire Development in Fetal and Neonatal Piglets. XI. The Relationship of Variable Heavy Chain Gene Usage and the Genomic Organization of the Variable Heavy Chain Locus

The isolator piglet: a model for studying the development of adaptive immunity

The Possible Role of Transplacentally‐Acquired Antibodies to Infectious Agents, With Molecular Mimicry to Nervous System Sialic Acid Epitopes, as Causes of Neuromental Disorders: Prevention and Vaccine Implications

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