The Antibiotic and Membrane-damaging Activities of Cellobiose Lipids and Sophorose Lipids

Kulakovskaya, Ekaterina; Баскунов, Б. П.; Zvonarev, Anton

doi:10.5650/jos.ess14037

Cited by 27 publications

(23 citation statements)

References 23 publications

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“…Interestingly, the hydroxylated form of CL is considered less bioactive against fungus and bacteria in solution. 35,70 These experiments confirm that the phenomena observed are not specific to sophorolipid, as previously assumed, 26 but they can be reproduced on surfaces coated with other glycoconjugate molecules. The conformation of the sugars is an important parameter to consider.…”

Section: Discussionsupporting

confidence: 84%

“…Cellobioselipid (CL), another microbial glycolipid with a cellobiose headgroup, produced by the fungus Ustilago maydis and also known to be a membrane disruptor, 35 is also tested for its structural proximity to sophorolipids. All compounds were immobilized on gold surfaces by grafting their free carboxylic acid moiety onto a self-assembled monolayer of short thiol amines, following the protocols developed in our previous works.…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial properties of glycosylated surfaces: variation of the glucosidal moiety and fatty acid conformation of grafted microbial glycolipids

Valotteau

Roelants

Dasaiyan

et al. 2020

Mol. Syst. Des. Eng.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Antibacterial properties of glycosylated surfaces: variation of the glucosidal moiety and fatty acid conformation of grafted microbial glycolipids

Valotteau

Roelants

Dasaiyan

et al. 2020

Mol. Syst. Des. Eng.

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“…2 a). SL are synthesized metabolically in two main forms, lactonic or acidic, that lead to a mixture of different congeners and quantities in the final production lines [ 53 , 54 ]. Acidic SL are alicyclic and have a carboxylic acid group (COOH) at the end of the hydrophobic portion, while lactonic SL are cyclic with ester functionality [ 55 , 56 ].…”

Section: Structural Classes Properties and Applicationsmentioning

confidence: 99%

Fungal biosurfactants, from nature to biotechnological product: bioprospection, production and potential applications

Silva

Banat

Giachini

et al. 2021

Bioprocess Biosyst Eng

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Biosurfactants are in demand by the global market as natural commodities that can be added to commercial products or use in environmental applications. These biomolecules reduce the surface/interfacial tension between fluid phases and exhibit superior stability to chemical surfactants under different physico-chemical conditions. Biotechnological production of biosurfactants is still emerging. Fungi are promising producers of these molecules with unique chemical structures, such as sophorolipids, mannosylerythritol lipids, cellobiose lipids, xylolipids, polyol lipids and hydrophobins. In this review, we aimed to contextualize concepts related to fungal biosurfactant production and its application in industry and the environment. Concepts related to the thermodynamic and physico-chemical properties of biosurfactants are presented, which allows detailed analysis of their structural and application. Promising niches for isolating biosurfactant-producing fungi are presented, as well as screening methodologies are discussed. Finally, strategies related to process parameters and variables, simultaneous production, process optimization through statistical and genetic tools, downstream processing and some aspects of commercial products formulations are presented.

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“…The antimicrobial activity of SLs is related to the synergistic effect of their sugar and lipid portions (surfactant effect) [9,11]. This mechanism is characterized by changes or rupture in the cellular membrane, inducing the outpouring of their cytoplasmic contents and the consequent release of intracellular enzymes, for instance, malate dehydrogenase indicating the interaction of SLs with the cellular membrane [12,13]. Although the mechanism of action of biosurfactants is not well known, an activity of altering charge-charge properties is hypothesized, which may decrease the chances for bacteria to acquire antibiotic resistance [14].…”

Section: Antimicrobial Activity Of Slsmentioning

confidence: 99%

Antimicrobial applications of sophorolipid from Candida bombicola: A promising alternative to conventional drugs

2018

jabb

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Sophorolipids (SLs) are extracellular glycolipids, produced mainly by yeast Candida bombicola, composed of a disaccharide sophorose (O-β-D-glucopyranosyl-2-1-β-D-glucopyranose) linked by a glycosidic bound to the terminal or sub-terminal carbon of a fatty acid chain. Due to these structural characteristics, SLs have been reported with several applications, which are directly related to the predominance of their acidic and lactonic forms. SLs are the most promising and attractive biosurfactant, highlighting its antimicrobial action against Gram-positive and Gram-negative bacteria. The antimicrobial activities of SLs are due to the mechanism of changes or rupture in the cellular membrane, inducing the outpouring of their cytoplasmic contents, and the consequent death of the pathogen. This surfactant can be used as an alternative for the substitution of conventional drugs.

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The Antibiotic and Membrane-damaging Activities of Cellobiose Lipids and Sophorose Lipids

Cited by 27 publications

References 23 publications

Antibacterial properties of glycosylated surfaces: variation of the glucosidal moiety and fatty acid conformation of grafted microbial glycolipids

Antibacterial properties of glycosylated surfaces: variation of the glucosidal moiety and fatty acid conformation of grafted microbial glycolipids

Fungal biosurfactants, from nature to biotechnological product: bioprospection, production and potential applications

Antimicrobial applications of sophorolipid from Candida bombicola: A promising alternative to conventional drugs

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