The anti-tumor potential of sinomenine: a narrative review

Abstract

Background and Objective Currently, chemotherapy is the main treatment for most tumors. However, drug resistance and many adverse reactions associated with chemotherapy greatly limit its use. Therefore, an increasing number of researchers have shifted the research focus the anti-tumor activity of traditional Chinese medicine. The objective of this article is to review the anti-tumor mechanism of sinomenine and its derivatives to provide a reference for further study and clinical transformation. Methods In this study, we searched for relevant articles on the anti-tumor mechanism of Sinomenium using databases such as PubMed and Medline. Key Content and Findings Sinomenine is a monomer alkaloid component extracted from the rhizome of Sinomenium acuturn . A number of basic studies have proven that sinomenine and its derivatives show significant anti-tumor activity in breast cancer, lung cancer, liver cancer, stomach cancer, ovarian cancer, osteosarcoma and other tumors. They can induce apoptosis and autophagic death of tumor cells, inhibit proliferation, migration and invasion of tumor cells, increase the sensitivity of tumor cells to radiotherapy and chemotherapy, and reverse the drug resistance through various molecular mechanisms. In addition, sinomenine can effectively relieve osteolysis and bone pain in tumor patients. At present, anti-tumor research on sinomenine remains in the basic experimental stage. Conclusions Sinomenine and its derivatives are rich in substances with high anti-tumor potential. This analysis provides a review of the anti-tumor effects and mechanisms of sinomenine, with the hope of further exploring the medical value of sinomenine in anti-tumor treatments.

Sinomenine ameliorates bleomycin-induced pulmonary fibrosis by inhibiting the differentiation of fibroblast into myofibroblast

“…Historically, SIN has been employed in Chinese medicine for centuries to treat arthritis due to its regulatory impact on the secretion of multiple inflammatory cytokines and immune cells [ 22 ]. Recent research has expanded the understanding of SIN's pharmacological activities, encompassing anti-tumor [ 23 ] and neuroprotective functions [ 24 ]. Feasible evidence suggests that SIN could attenuate renal fibrosis through Nrf2-mediated inhibition of oxidative stress and TGF-β1 signaling [ 25 ].…”