GLUT and HK: Two primary and essential key players in tumor glycolysis

Yadav, Dhiraj; Yadav, Anubha; Bhattacharya, Sujata; Dagar, Akansha; Kumar, Vinit; Rani, Reshma

doi:10.1016/j.semcancer.2024.03.001

Cited by 4 publications

(1 citation statement)

References 152 publications

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“…Indeed, it has been reported that overexpression of GLUTs correlates with aggressive tumor behavior since glycolytic-dominancy also known as "Warburg effect," is a key element for tumors growth and invasion. 34,35 Our findings are in line with what reported in literature, since it has been demonstrated that in pancreatic ductal adenocarcinoma cells, PON2 promoted cell proliferation by enhancing glucose transport, while in B cell acute lymphoblastic leukemia enabled glucose uptake by preventing stomatin-mediated inhibition of Glut1. 20 Finally, the loss of endogenous PON2 expression impaired key aspects of oxidative metabolism in lung adenocarcinoma cells, leading to the hindrance of cell proliferation.…”

Section: Discussionsupporting

confidence: 92%

Paraoxonase‐2 shRNA‐mediated gene silencing suppresses proliferation and migration, while promotes chemosensitivity in clear cell renal cell carcinoma cell lines

Schiavoni,

Emanuelli,

Campagna

et al. 2024

J of Cellular Biochemistry

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Clear cell renal cell carcinoma (ccRCC) represents the most common subtype of renal tumor. Despite recent advances in identifying novel target molecules, the prognosis of patients with ccRCC continues to be poor, mainly due to the lack of sensitivity to chemo‐ and radiotherapy and because of one‐third of renal cell carcinoma patients displays metastatic disease at diagnosis. Thus, identifying new molecules for early detection and for developing effective targeted therapies is mandatory. In this work, we focused on paraoxonase‐2 (PON2), an intracellular membrane‐bound enzyme ubiquitously expressed in human tissues, whose upregulation has been reported in a variety of malignancies, thus suggesting its possible role in cancer cell survival and proliferation. To investigate PON2 involvement in tumor cell metabolism, human ccRCC cell lines were transfected with plasmid vectors coding short harpin RNAs targeting PON2 transcript and the impact of PON2 silencing on cell viability, migration, and response to chemotherapeutic treatment was then explored. Our results showed that PON2 downregulation was able to trigger a decrease in proliferation and migration of ccRCC cells, as well as an enhancement of cell sensitivity to chemotherapy. Thus, taken together, data reported in this study suggest that the enzyme may represent an interesting therapeutic target for ccRCC.

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Section: Discussionsupporting

confidence: 92%

Paraoxonase‐2 shRNA‐mediated gene silencing suppresses proliferation and migration, while promotes chemosensitivity in clear cell renal cell carcinoma cell lines

Schiavoni,

Emanuelli,

Campagna

et al. 2024

J of Cellular Biochemistry

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Glucose Transporter 1 Inhibitors Induce Autophagy and Synergize With Lenvatinib in Thyroid Cancer Cells

Kuo,

Hsu,

Chen

et al. 2024

Head & Neck

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BackgroundLess differentiated thyroid cancer may upregulate the expression of glucose transporter 1 (GLUT1) and increase glycolytic activity. However, it is uncertain whether GLUT1 can be used as a target for therapy.MethodsThyroid cancer cell lines were treated with two different GLUT1 inhibitors, STF‐31 and BAY‐876. Functional assays were conducted to evaluate the effects of these inhibitors on cell biology.ResultsGLUT1 inhibitors dose‐dependently decreased cell growth and clonogenicity of thyroid cancer cells. Cell cycle analysis showed that these inhibitors caused G2/M arrest instead of apoptosis. Additionally, treatment with GLUT1 inhibitors led to the activation of autophagy. In both the Transwell and spheroid models, GLUT1 inhibitors significantly suppressed cell invasiveness. Moreover, GLUT1 inhibitors demonstrated synergistic interactions when combined with lenvatinib.ConclusionsTreatment with GLUT1 inhibitors activates autophagy and provokes cell cycle arrest, accompanied by a decrease in colony formation and invasive capacity in thyroid cancer cells.

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Regulatory mechanisms and potential therapeutic targets in precancerous lesions of gastric cancer: A comprehensive review

Zhang,

Zhong,

Song

et al. 2024

Biomedicine & Pharmacotherapy

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GLUT and HK: Two primary and essential key players in tumor glycolysis

Cited by 4 publications

References 152 publications

Paraoxonase‐2 shRNA‐mediated gene silencing suppresses proliferation and migration, while promotes chemosensitivity in clear cell renal cell carcinoma cell lines

Paraoxonase‐2 shRNA‐mediated gene silencing suppresses proliferation and migration, while promotes chemosensitivity in clear cell renal cell carcinoma cell lines

Glucose Transporter 1 Inhibitors Induce Autophagy and Synergize With Lenvatinib in Thyroid Cancer Cells

Regulatory mechanisms and potential therapeutic targets in precancerous lesions of gastric cancer: A comprehensive review

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