The anti-inflammatory properties of HDLs are impaired in gout

Wang, Yuan; Wang, Yan; Jia, Xiaoxia; Wang, Zongwei; Li, Xin; Lin, Ming Tsan; Zhang, Baoyu

doi:10.1007/s10067-020-05374-z

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…Gout is linked to dyslipidemia, and high SUA levels are positively correlated with LDL cholesterol and hypertriglyceridemia 18 . At the same time, impairment occurs in the anti‐inflammatory functions of HDL cholesterol in patients with gout, and this is independent of hyperlipidemia 19 . In addition, studies have shown that disturbances in the lipid profile may play a role in the pathogenesis of hearing loss in patients with gout.…”

Section: Discussionmentioning

confidence: 99%

“…18 At the same time, impairment occurs in the anti-inflammatory functions of HDL cholesterol in patients with gout, and this is independent of hyperlipidemia. 19 In addition, studies have shown that disturbances in the lipid profile may play a role in the pathogenesis of hearing loss in patients with gout. Yücel et al showed that HDL levels were positively correlated with TEOAE S/N and negatively correlated with audiometry thresholds.…”

Section: F I G U R E 1 (A) Hearing Thresholds Of Right Ear (B) Hearin...mentioning

confidence: 99%

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Early hearing loss detection in gout using extended high frequency audiometry

Şahin

Kılıç

Sakat

et al. 2022

Clinical Otolaryngology

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Objective The study aimed to analyse the hearing levels of patients with gout using extended high frequencies (EHFs) audiometry. Thus, we aimed to reveal the early detectability of potential hearing losses. Design Comparative cross‐sectional study. Settings A single centre patient was diagnosed with gout disease. Participants Two groups consisted of 32 patients with gout and 32 healthy volunteers. Main Outcome Measures The primary outcome was hearing thresholds in pure tone (PT) audiometry and EHFs audiometry. Also, the association between audiometric results and haematological and biochemical parameters were evaluated. Results There was no significant difference between groups in terms of mean hearing thresholds in PT audiometry. But, at all frequencies above 4000 Hz (4000–18 000 Hz), the hearing thresholds were significantly higher in patients with gout. Also, the hearing thresholds above 8000 Hz were positively correlated with serum uric acid levels. Hearing thresholds at higher frequencies were positively correlated with haemoglobin levels and negatively correlated with high‐density lipoprotein levels. Conclusion To our knowledge, this is the first study in the literature demonstrating the high frequency of hearing loss in patients with gout using EHFs audiometry. We consider that using EHFs audiometry should have an important place in the early detection of potential hearing losses in gout patients.

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Section: Discussionmentioning

confidence: 99%

Section: F I G U R E 1 (A) Hearing Thresholds Of Right Ear (B) Hearin...mentioning

confidence: 99%

Early hearing loss detection in gout using extended high frequency audiometry

Şahin

Kılıç

Sakat

et al. 2022

Clinical Otolaryngology

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“…In addition, activities of key RCT mediators, lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP), can be used as indicators of RCT effectiveness [52]. The anti-inflammatory properties of HDL can also be assessed by several methods, which are generally based on co-incubation of different cell types with HDL and measurement of the cellular response to inflammatory stimuli [52,56]. It was proposed that the HDL inflammatory index (calculated as a ratio of the measured effects with and without the presence of HDL in cell culture) could be used as a metric for HDL's anti-inflammatory properties [57].…”

Section: Functional Characteristics Of Hdl Particles In Crcmentioning

confidence: 99%

Revealing the Role of High-Density Lipoprotein in Colorectal Cancer

Zeljković

Mihajlović

Gojković

et al. 2021

IJMS

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Colorectal cancer (CRC) is a highly prevalent malignancy with multifactorial etiology, which includes metabolic alterations as contributors to disease development. Studies have shown that lipid status disorders are involved in colorectal carcinogenesis. In line with this, previous studies have also suggested that the serum high-density lipoprotein cholesterol (HDL-C) level decreases in patients with CRC, but more recently, the focus of investigations has shifted toward the exploration of qualitative properties of HDL in this malignancy. Herein, a comprehensive overview of available evidences regarding the putative role of HDL in CRC will be presented. We will analyze existing findings regarding alterations of HDL-C levels but also HDL particle structure and distribution in CRC. In addition, changes in HDL functionality in this malignancy will be discussed. Moreover, we will focus on the genetic regulation of HDL metabolism, as well as the involvement of HDL in disturbances of cholesterol trafficking in CRC. Finally, possible therapeutic implications related to HDL will be presented. Given the available evidence, future studies are needed to resolve all raised issues concerning the suggested protective role of HDL in CRC, its presumed function as a biomarker, and eventual therapeutic approaches based on HDL.

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“…According to the Third National Health and Nutrition Examination Survey Report in the United States, after adjusting for age and sex, elevated high-density lipoproteins in gout patients can lower the risk of gout. Studies have shown [46][47][48] that serum uratemediated effect between HDL-C and gout, suggesting that elevated HDL-C can reduce serum urate, thus directly affecting gout and indirectly lowering the risk of gout. Our research showed that HDL-C is a risk factor for kidney stone formation in gout patients, and its mechanism might be related to its impaired anti-inflammatory activity.…”

mentioning

confidence: 99%

Analysis of Risk Factors for Changes in the Renal Two-Dimensional Image in Gout Patients

Dang¹,

Xu²,

Luo³

et al. 2021

IJGM

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To explore the effects of different blood uric acid levels in gout patients on the twodimensional image of the kidney and the risk factors for gout-related kidney damage for providing clinical evidence to enable early prevention and treatment of gout-related kidney damage. Methods: We obtained information of 227 patients with primary gout and estimated the association between two-dimensional kidney images and clinical indicators using binary logistic regression. Results: Our study showed that different uric acid levels, age, disease course, cystatin C (CysC) level, and γ-glutamyl transpeptidase level were correlated with echo of the renal medulla (P < 0.05). CysC level was correlated with the renal cortex thickness and kidney stones in different uric acid-level groups (P < 0.05). Disease course, aspartate transaminase (AST) level, creatinine (CREA) level, and tophi were risk factors for renal cortex thinning in gout patients (P = 0.045, 0.026, 0.004, 0.006, respectively). The disease course, platelet (PLT) count, and high-density lipoprotein (HDL-C) level were risk factors for kidney stone formation in gout patients (P = 0.037, 0.022, 0.023, respectively), while CysC level and C-reactive protein (CRP) level were risk factors for increased renal medulla echo in these patients (P = 0.022, 0.028, respectively). Conclusion:Our study revealed disease course, AST level, CREA level, tophi, PLT count, HDL-C level, CysC level and CRP level may be important predictors of renal image changes.

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The anti-inflammatory properties of HDLs are impaired in gout

Cited by 4 publications

References 21 publications

Early hearing loss detection in gout using extended high frequency audiometry

Early hearing loss detection in gout using extended high frequency audiometry

Revealing the Role of High-Density Lipoprotein in Colorectal Cancer

Analysis of Risk Factors for Changes in the Renal Two-Dimensional Image in Gout Patients

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