The anti‐inflammatory effects of 1,25‐dihydroxyvitamin D3 on Th2 cells in vivo are due in part to the control of integrin‐mediated T lymphocyte homing

Abstract

The fat soluble vitamin D3 metabolite 1,25-dihydroxyvitamin D3 [1,25(OH)

Vitamin D Receptor-Deficient Mice Fail to Develop Experimental Allergic Asthma

“…Matheu et al (18) used a different strain of mouse (B10.RIII) and there were other differences in the experimental protocol including injecting 1,25(OH) 2 D 3 every other day instead of feeding the mice continuously. More recently, Topilski et al (19) reported that 1,25(OH) 2 D 3 suppressed eosinophilia, and lung inflammation scores in what may be the same model of allergic asthma induced in either BALB/c or C57BL/6 mice. Unfortunately, the experimental details of the Topilski et al experiments are not clearly stated.…”

“…Unfortunately, the experimental details of the Topilski et al experiments are not clearly stated. There could be differences in the OVA immunization, OVA dose, and what type of mice were used (BALB/c or C57BL/6, and it is unclear whether intranasal or aerosolized exposure of the mice was done (19). In addition, 1,25(OH) 2 D 3 was injected and not fed (19).…”

Reconsidering the connection between vitamin D levels and age-related macular degeneration

“…Therefore, it is unlikely that our negative results are explained by type II error. Several studies have reported that vitamin D decreases the proliferation of T-helper cells, 23 T-cytotoxic cells and natural killer cells 24 and enhances T-suppressor cell activity. 31 Other studies have reported that vitamin D also decreases the production of proinflammatory agents, such as IL-2, 25,26 IL-8, 27 IL-6 28 and IL-12.…”

“…[11][12][13][14]16 Evidence of inflammatory cell involvement in the later stages of AMD includes the presence of multinucleated giant cells and leukocytes in the choroid of AMD eyes 15 and in excised choroidal neovascularization. 20,22 A number of in vitro and in vivo studies have suggested an anti-inflammatory role for vitamin D. 23,24 It was also shown that vitamin D reduces the proliferation of cells of the immune system, [25][26][27][28][29] and that there is an inverse relationship between vitamin D levels and several chronic conditions associated with inflammation. [30][31][32][33] Owing to the potential causative role of inflammation in AMD development and progression, it is possible that vitamin D may protect against the occurrence and progression of AMD by virtue of its anti-inflammatory properties.…”

Vitamin D receptor expression by the lung micro-environment is required for maximal induction of lung inflammation

“…The active form of vitamin D (1,25-dihydroxyvitamin D3; 1,25(OH) 2 D 3 ) can modulate the immune response with beneficial effects on autoimmune diseases (reviewed in [4]). In models of experimental allergic asthma there is evidence that 1,25(OH) 2 D 3 treatment can be beneficial [5,6], has no effect [7] or is harmful [5,7] when various markers of this disease are examined. More information on the role of vitamin D and 1,25(OH) 2 D 3 in experimental asthma is required to resolve the controversy.…”