Reconsidering the connection between vitamin D levels and age-related macular degeneration

Golan, Shani; Shalev, Varda; Treister, Giora; Chodick, Gabriel; Loewenstein, Anat

doi:10.1038/eye.2011.174

Cited by 43 publications

(36 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some studies did not found an association between levels of vitamin D and AMD, 71,72 in contrast with the majority of studies showing a significant correlation between reduced plasma level of vitamin D and a higher prevalence of the disease. [73][74][75][76][77][78] A biologically plausible explanation has been provided by studies showing immunomodulatory and antiangiogenic properties of vitamin D. 79 Worth of noting, a recent study, that demonstrated a protective role of ultraviolet irradiance against the development of neovascular AMD, identified an association between genetic variation in the major vitamin D catabolic gene, and risk for all forms of AMD.…”

Section: Accepted Manuscriptmentioning

confidence: 56%

Geo-Epidemiology of Age-Related Macular Degeneration: New Clues Into the Pathogenesis

Reibaldi

Longo

Pulvirenti

et al. 2016

American Journal of Ophthalmology

View full text Add to dashboard Cite

Section: Accepted Manuscriptmentioning

confidence: 56%

Geo-Epidemiology of Age-Related Macular Degeneration: New Clues Into the Pathogenesis

Reibaldi

Longo

Pulvirenti

et al. 2016

American Journal of Ophthalmology

View full text Add to dashboard Cite

“…First, Day et al (12), in a retrospective study, found no association between diagnosis of vitamin D deficiency and incidence of first diagnosis of non-neovascular and neovascular AMD in Medicare beneficiaries. Golan et al (13) found that which allowed studying seasonal variations. Third, the major potential confounders were taken into account, including sociodemographic status, factors related to vascular diseases, BMI, use of lipid-lowering medications, and the major AMDrelated genetic polymorphisms.…”

Section: Discussionmentioning

confidence: 98%

“…Indeed, vitamin D might protect against the onset and progression of AMD, in particular because of its anti-inflammatory properties (8,10,11). However, few epidemiologic studies have evaluated the relation between AMD and vitamin D status, with conflicting results (10)(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 98%

Vitamin D Deficiency in Community-Dwelling Elderly Is Not Associated with Age-Related Macular Degeneration

Cougnard‐Grégoire

Merle

Korobelnik

et al. 2015

The Journal of Nutrition

View full text Add to dashboard Cite

show abstract

“…27–29 Research in the Carotenoids in Age-Related Eye Disease Study (CAREDS) showed that postmenopausal women <75 years of age had an increased odds of AMD if they had low versus high vitamin D status assessed with intake of vitamin D and 25(OH)D concentrations. 23 We proposed 1) to investigate whether this previously observed association between 25(OH)D and AMD was stronger in women with established AMD risk genotypes, including several which influence inflammatory pathways, and 2) to investigate the association between AMD and SNPs in genes involved in vitamin D transport, metabolism and genomic function.…”

Section: Introductionmentioning

confidence: 99%

Association Between Vitamin D Status and Age-Related Macular Degeneration by Genetic Risk

et al. 2015

View full text Add to dashboard Cite

IMPORTANCE Deficient 25-hydroxyvitamin D (25[OH]D) concentrations have been associated with increased odds of age-related macular degeneration (AMD).OBJECTIVE To examine whether this association is modified by genetic risk for AMD and whether there is an association between AMD and single-nucleotide polymorphisms of genes involved in vitamin D transport, metabolism, and genomic function. DESIGN, SETTING, AND PARTICIPANTS Postmenopausal women (N = 913) who were participants of the Carotenoids in Age-Related Eye Disease Study (CAREDS) (aged 54 to <75 years) with available serum 25(OH)D concentrations (assessed October 1, 1993, to December 31, 1998), genetic data, and measures of AMD (n = 142) assessed at CAREDS baseline from May 14, 2001, through January 31, 2004, were studied.MAIN OUTCOMES AND MEASURES Prevalent early or late AMD was determined from graded, stereoscopic fundus photographs. Logistic regression was used to estimate odds ratios (ORs) and 95% CIs for AMD by the joint effects of 25(OH)D (<12, Ն12 to <20, Ն20 to <30, and Ն30 ng/mL) and risk genotype (noncarrier, 1 risk allele, or 2 risk alleles). The referent group was noncarriers with adequate vitamin D status (Ն30 ng/mL). Joint effect ORs were adjusted for age, smoking, iris pigmentation, self-reported cardiovascular disease, self-reported diabetes status, and hormone use. Additive and multiplicative interactions were assessed using the synergy index (SI) and an interaction term, respectively. To examine the association between AMD and variants in vitamin D-related genes, age-adjusted ORs and 95% CIs were estimated using logistic regression. RESULTS Among the 913 women, 550 had adequate levels of vitamin D (Ն20 ng/mL), 275 had inadequate levels (Ն12 to <20 mg/mL), and 88 had deficient levels (<12 ng/mL). A 6.7-fold increased odds of AMD (95% CI, 1.6-28.2) was observed among women with deficient vitamin D status (25[OH]D <12 ng/mL) and 2 risk alleles for CFH Y402H (SI for additive interaction, 1.4; 95% CI, 1.1-1.7; P for multiplicative interaction = .25). Significant additive (SI, 1.4; 95% CI, 1.1-1.7) and multiplicative interactions (P = .02) were observed for deficient women with 2 high-risk CFI (rs10033900) alleles (OR, 6.3; 95% CI, 1.6-24.2). The odds of AMD did not differ by genotype of candidate vitamin D genes. CONCLUSIONS AND RELEVANCEIn this study, the odds of AMD were highest in those with deficient vitamin D status and 2 risk alleles for the CFH and CFI genotypes, suggesting a synergistic effect between vitamin D status and complement cascade protein function. Limited sample size led to wide CIs. Findings may be due to chance or explained by residual confounding.

show abstract

Reconsidering the connection between vitamin D levels and age-related macular degeneration

Cited by 43 publications

References 47 publications

Geo-Epidemiology of Age-Related Macular Degeneration: New Clues Into the Pathogenesis

Geo-Epidemiology of Age-Related Macular Degeneration: New Clues Into the Pathogenesis

Vitamin D Deficiency in Community-Dwelling Elderly Is Not Associated with Age-Related Macular Degeneration

Association Between Vitamin D Status and Age-Related Macular Degeneration by Genetic Risk

Contact Info

Product

Resources

About