Geo-Epidemiology of Age-Related Macular Degeneration: New Clues Into the Pathogenesis

Reibaldi, Michele; Longo, Antonio; Pulvirenti, Alfredo; Avitabile, Teresio; Russo, Andrea; Cillino, Salvatore; Mariotti, Cesare; Casuccio, Alessandra

doi:10.1016/j.ajo.2015.09.031

Cited by 37 publications

(33 citation statements)

References 73 publications

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“…We already saw the positive action on retinal electrical activity in our previous study, and the current study has shown that scotopic ERG, BCVA and sensitivity detected by MY appear to be more intense in thicker retinas (Table 2, Figure 2, 3, and 4) [4, 19]. On the contrary, natural evolution shows inevitable visual impairment, according to clinical events [1–3]. …”

Section: Discussionsupporting

confidence: 51%

“…Age-related macular degeneration (AMD) is a heterogeneous clinical condition in which retinal degeneration occurs predominantly in the macula and leads to impairment of central visual acuity [1, 2]. AMD, the leading cause of blindness in people aged 55 years or older in developed countries, occurs in two general forms: 1) Wet AMD involving choroidal neovascularization with subsequent bleeding and fluid exudation; 2) Dry AMD, which involves a constellation of clinical features that can include: drusen, pigment clumping, abnormalities of the retinal pigment epithelium (RPE), and geographic atrophy (GA) [1–3].…”

Section: Introductionmentioning

confidence: 99%

“…AMD, the leading cause of blindness in people aged 55 years or older in developed countries, occurs in two general forms: 1) Wet AMD involving choroidal neovascularization with subsequent bleeding and fluid exudation; 2) Dry AMD, which involves a constellation of clinical features that can include: drusen, pigment clumping, abnormalities of the retinal pigment epithelium (RPE), and geographic atrophy (GA) [1–3]. The latter can begin as a thinning of the RPE and lead subsequently to an atrophic change in the macula with loss of overlying photoreceptors [2–4].…”

Section: Introductionmentioning

confidence: 99%

“…It is known that smoking may slow down choroidal blood flow, promoting ischemia, hypoxia, and microinfarctions, resulting in a reduction in macular pigments and in RPE damage. Oral supplement of antioxidants and smoking cessation can help to prevent or counter AMD development and progression [1–3]. However, dry AMD progression reduces VP causing discomfort to patients who become increasingly more visually impaired [3–4].…”

Section: Introductionmentioning

confidence: 99%

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Cell surgery and growth factors in dry age-related macular degeneration: visual prognosis and morphological study

Limoli¹,

Limoli²,

Vingolo

et al. 2016

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BackgroundThe aim of this research was to study the overall restoration effect on residual retinal cells through surgically grafted autologous cells onto the surrounding tissue, choroid and retina in order to produce a constant secretion of growth factors (GFs) in dry age-related macular degeneration (AMD) patients.Results6 months after surgery, several values were statistically significant in the group with higher RTA. Also patient compliance analysis (PCA) in relation to functional change perception appeared to be very good.MethodsThirty-six eyes of 25 patients (range 64-84 years of age) affected by dry AMD were included in study, and divided in two groups by spectral domain-optical coherence tomography (SD-OCT): group A with retinal thickness average (RTA) less than 250 microns (μm) and group B with RTA equal to or more than 250 μm. Adipocytes, adipose-derived stem cells from the stromal-vascular fraction, and platelets from platelet-rich plasma were implanted in the suprachoroidal space. Particularly, the following parameters were evaluated: best corrected visual acuity (BCVA) for far and near distance, retinal thickness maps, scotopic and photopic electroretinogram (ERG), and microperimetry (MY). All statistical analyses were performed with STATA 14.0 (Collage Station, Texas, USA).ConclusionsThe available set of GFs allowed biological retinal neuroenhancement. After 6 months it improved visual performance (VP), but the increase was better if RTA recorded by OCT was higher, probably in relation to the presence of areas with greater cellularity.

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Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cell surgery and growth factors in dry age-related macular degeneration: visual prognosis and morphological study

Limoli¹,

Limoli²,

Vingolo

et al. 2016

Oncotarget

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“…11 Polysomnograms were analysed and Apnoea/ Hypopnoea Index (AHI) was calculated as the number of obstructive apnoea episodes (complete cessation of airflow for at least 10 s) and of hypopnoea episodes (an airflow reduction of >50% for at least 10 s with a decrease in oxygen saturation of >3%) despite ongoing inspiratory efforts per hour of sleep. 12 An AHI of ≥5 events/hour was considered suggestive of OSA, defined as mild (5)(6)(7)(8)(9)(10)(11)(12)(13)(14), moderate (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) or severe (>30).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors of eye diseases in adult patients with obstructive sleep apnoea: results from the SLE.E.P.Y cohort study

et al. 2017

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ObjectivesTo assess the occurrence of glaucoma, eyelid, corneal and macular disorders in a cohort of patients with obstructive sleep apnoea (OSA) diagnosed by overnight polysomnography and to investigate into the risk factors for the above eye diseases (EDs).DesignCross-sectional cohort study between 2014 and 2015.SettingUnit of Respiratory Medicine and Eye Clinic of the University of Verona.Participants431 consecutive patients were considered eligible. Of these, 87 declined to participate, 35 were untraceable and 13 were deceased.InterventionsA complete ophthalmic evaluation of both eyes for each patient.Primary and secondary outcome measuresBest-corrected distance visual acuity, intraocular pressure, corneal, macular and optic nerve optical coherence tomography, ocular aberrometry, optic nerve laser polarimetry, visual field test, and eyelid examination.Results296 patients aged 64.5±12.8 years, 23% female and 77% male, underwent ophthalmic examination. There was 56% (n=166) prevalence of eyelid disorders, 27% (n=80) of corneal disorders, 13% (n=39) of macular disorders and 11% (n=33) of glaucoma. Advancing age was not associated with the severity of OSA, while significant differences were found for gender, body mass index, Oxygen Desaturation Index, smoking habit, hypertension and diabetes. Severe OSA was significantly associated with glaucoma (OR, 95% CI 1.05 to 5.93, p=0.037).ConclusionsEDs were more prevalent in our patinets with OSA than in the general population. Severe Apnoea/Hypopnoea Index level seemed to play a role as risk factor only for glaucoma.

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Molecular Mechanisms of Retina Pathology and Ways of Its Correction

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Geo-Epidemiology of Age-Related Macular Degeneration: New Clues Into the Pathogenesis

Cited by 37 publications

References 73 publications

Cell surgery and growth factors in dry age-related macular degeneration: visual prognosis and morphological study

Cell surgery and growth factors in dry age-related macular degeneration: visual prognosis and morphological study

Prevalence and risk factors of eye diseases in adult patients with obstructive sleep apnoea: results from the SLE.E.P.Y cohort study

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