The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS

Fan, Guanwei; Gao, Xiumei; Wang, Hong; Zhu, Yan; Zhang, Ju; Hu, Limin; Su, Yi; Kang, Lan; Zhang, Boli

doi:10.1016/j.jsbmb.2009.01.011

Cited by 185 publications

(145 citation statements)

References 24 publications

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“…TanIIA also inhibited the translocation of Cdk5 from the nucleus into the cytoplasm of primary neurons induced by Aβ [25][26][27][28][29][30][31][32][33][34][35] . Fan and coworkers [41] demonstrated that TSAII exerts anti-inflammatory effects by inhibition of inflammation cytokine (IL-1β, IL-6, and TNF-α) expression via the ER-dependent pathway and inhibition of iNOS gene expression and NO production. Proinflammatory cytokines have been implicated in the disruption of the BBB and the invasion of inflammatory cells into the CNS [41].…”

Section: Tanshinone Iiamentioning

confidence: 99%

“…Fan and coworkers [41] demonstrated that TSAII exerts anti-inflammatory effects by inhibition of inflammation cytokine (IL-1β, IL-6, and TNF-α) expression via the ER-dependent pathway and inhibition of iNOS gene expression and NO production. Proinflammatory cytokines have been implicated in the disruption of the BBB and the invasion of inflammatory cells into the CNS [41]. TSAII suppressed the expression of proinflammatory cytokines TNF-α and IL-8, upregulated the expression of the anti-inflammatory cytokine IL-10, and increased the TGF-β1 level.…”

Section: Tanshinone Iiamentioning

confidence: 99%

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Effects of Salvia miltiorrhiza on CNS Neuronal Injury and Degeneration: A Plausible Complementary Role of Tanshinones and Depsides

Bonaccini

Karioti²,

Bergonzi

et al. 2015

Planta Med

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Section: Tanshinone Iiamentioning

confidence: 99%

Section: Tanshinone Iiamentioning

confidence: 99%

Effects of Salvia miltiorrhiza on CNS Neuronal Injury and Degeneration: A Plausible Complementary Role of Tanshinones and Depsides

Bonaccini

Karioti²,

Bergonzi

et al. 2015

Planta Med

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“…However, treatment with isoliquiritigenin had no significant effect on these molecules, suggesting that the anti-angiogenesis action of Tanshinone IIA, isolated from the root of Salvia miltiorrhiza, is widely used in the prescriptions for treating vascular diseases. While the scientific evidence supporting its beneficial effect on vasculature in humans is not well established, some studies showed that tanshinone IIA protects against vascular inflammation and promotes vasodilatation [34][35][36]. In addition, tanshinone IIA has been shown to inhibit proliferation and migration of cancer cells [37][38][39].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Isoliquiritigenin Inhibits Angiogenesis Ex Vivo and Corneal Neovascularization in Mice

Yang¹,

He²,

Qu³

et al. 2014

Altern Integr Med

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Neovascularization is often involved in many diseases and there is no effective treatment for this pathological process. In searching for potential therapies for neovascularization, we screened nineteen pre-selected small molecules isolated from herbal extracts for their possible anti-angiogenic effect in vitro and in vivo. We found that isoliquiritigenin, a chalconoid compound isolated from Chinese herb medicine licorice, potently inhibited vascular endothelial cell (EC) proliferation, migration, tube -like structure formation ex vivo. Western blot analysis shows that exposure of ECs to isoliquiritigenin inhibited extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation. In Matrigel plug assay, isoliquiritigenin effectively blocked fibroblast growth factor-induced in vivo angiogenesis in mice. Consistently, topical application of isoliquiritigenin significantly inhibited chemical injury-induced corneal neovascularization in mice. Collectively, these results suggest that isoliquiritigenin may be a low-cost and effective natural agent to treat angiogenesis-dependent diseases.

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“…그러므로 혈액뇌관문 7,8) . 丹蔘에 대한 실험적 연구로 항염증 9) , 항혈전 10), 항산화 11) , 항알레르기 12) , 신경세포 자연사 13) 및 뇌세포 보호 효과 (Fig. 1).…”

Section: 서 론 1)unclassified

Effects of Salviae Miltiorrhizae Radix on Blood-Brain Barrier Impairment of ICH-Induced Rats

Park¹,

Kim²

2014

The Korea Journal of Herbology

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Objectives : This study was performed in order to evaluate the effects of Salviae Miltiorrhizae Radix (SMR) water extract against the cerebral hemorrhage and the blood-brain barrier (BBB) impairment in the intracerebral hemorrhage (ICH). Method : ICH was induced by the stereotaxic intrastriatal injection of bacterial collagenase type IV in Sprague-Dawley rats. SMR was orally given three times every 20 hours during 3 days after the ICH induction. Hematoma volume, water content of brain tissue and volume of evans blue leakage were examined. Myeloperoxidase (MPO) positive neutrophils and tumor necrosis factor-α (TNF-α) were observed with immunofluorescence labeling and confocal microscope. Results : SMR significantly reduced the hematoma volume of the ICH-induced rat brain. SMR significantly reduced the water content of brain tissue of the ICH-induced rat brain. SMR reduced the percentage of the evans blue leakage around the hematoma on the caudate putamen compared to the ICH group, especially on the cerebral cortex. SMR significantly reduced the volume of the evans blue leakage level in the peri-hematoma regions of the ICH-induced rat brain. SMR significantly reduced MPO positive neutrophils in the peri-hematoma regions of the ICH-induced rat brain. SMR reduced the TNF-α expression in peri-hematoma regions of the ICH-induced rat brain. TNF-α immuno-labeled cells were coincided with MPO immuno-labeled neutrophils in peri-hematoma regions of the ICH-induced rat brain. Conclusion : These results suggest that SMR plays a protective role against the blood-brain barrier impairment in the ICH through suppression of inflammation in the rat brain tissues.

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The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS

Cited by 185 publications

References 24 publications

Effects of Salvia miltiorrhiza on CNS Neuronal Injury and Degeneration: A Plausible Complementary Role of Tanshinones and Depsides

Effects of Salvia miltiorrhiza on CNS Neuronal Injury and Degeneration: A Plausible Complementary Role of Tanshinones and Depsides

Phytochemical Isoliquiritigenin Inhibits Angiogenesis Ex Vivo and Corneal Neovascularization in Mice

Effects of Salviae Miltiorrhizae Radix on Blood-Brain Barrier Impairment of ICH-Induced Rats

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