The anti-diabetic effects of ethanol extract from two variants of Artemisia princeps Pampanini in C57BL/KsJ-db/db mice

Jung, Un Ju; Baek, Nam‐In; Chung, Hae‐Gon; Bang, Myun‐Ho; Yoo, Jinhwa; Jeong, Tae Sook; Lee, K T; Kang, Young-Jin; Lee, M K; Kim, H J; Yeo, Jiyoung; Choi, Myung‐Sook

doi:10.1016/j.fct.2007.04.021

Cited by 70 publications

(51 citation statements)

References 45 publications

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“…Several enzymes may be involved, but the best described in this regard are hepatic glucokinase and glucose-6-phosphatase [30,31] . Previous studies have reported that altered hepatic glucokinase and glucose-6-phosphatase activities result in the abnormal hepatic glycogen synthesis associated with the diabetic condition [32,33] . These studies also report that intervention with antidiabetic plant extracts or synthesized organic compounds further influence these enzymes, increasing liver glycogen synthesis and in turn lowering FBG levels [30,31] .…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Onion (<i>Allium cepa</i> L.) in a High-Fat Diet Streptozotocin-Induced Diabetes Rodent Model

Islam¹,

Choi²,

Loots³

2008

Ann Nutr Metab

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Background/Aims: The present study was conducted to investigate the effects of two dietary doses of freeze-dried onion powder on diabetes-related symptoms in a high-fat (HF) diet streptozotocin (STZ)-induced diabetes rat model. Methods: Five-week-old male Sprague-Dawley rats were fed a HF diet for 2 weeks and then randomly divided into 4 groups as follows: HF control (HFC), diabetic control (DBC), onion low (ONL; 0.5%) and onion high (ONH; 2.0%). Diabetes was induced by an intraperitoneal injection of STZ (40 mg/kg body weight) in all groups except the HFC group. Results: After 4 weeks on the experimental diets, fasting blood glucose levels for both onion-fed groups were higher than in the DBC and HFC groups, albeit only significantly so (p < 0.05) in the ONL group. Serum insulin concentrations and insulin resistance were dose-dependently increased (however, not significantly so) in the onion-fed groups compared to the DBC group. Pancreatic β-cell function and liver glycogen concentrations were nonsignificantly higher in the DBC and ONH groups compared to the ONL group. Additionally, the ONH group had significantly higher lipid concentrations (except for high-density lipoprotein cholesterol) compared to all other groups. The ONL group showed a similar hyperlipidemic trend, however to a lesser extent, with only triglycerides significantly differing from those of the DBC and HFC groups. Conclusion: The results suggest that the HF onion diet may increase insulin secretion and consequently insulin resistance in a dose-dependent manner, resulting in a worsened hyperglycemic and hyperlipidemic diabetic state. We conclude that higher dietary fat may impair the antidiabetic effects of dietary onion intake as has been previously reported.

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Section: Discussionmentioning

confidence: 99%

Effects of Dietary Onion (<i>Allium cepa</i> L.) in a High-Fat Diet Streptozotocin-Induced Diabetes Rodent Model

Islam¹,

Choi²,

Loots³

2008

Ann Nutr Metab

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“…7,8) The active constituent is thought to be a flavone, eupatilin, which had a functional anti-diabetic effect by enhancing hepatic and plasma glucose metabolism. 8) Hence, we analyzed the amount of eupatilin in our APE by HPLC analysis, and confirmed that our APE did not contain eupatilin.…”

Section: Discussionmentioning

confidence: 99%

“…A previous study reported that one of the flavones, eupatilin, is an active compound in A. princeps. 7,8) We checked the amount of eupatilin in our APE as compared with standard compounds obtained from PhytoLab (Vestenbergsgreuth, Germany), and confirmed that our APE did not contain eupatilin. We could not identify some peaks because they were absent from our polyphenolic library data, but one of the unidentified a The phenolic content of APE was determined using an HPLC system constructed for simultaneous determination of polyphenols in foods.…”

Section: Polyphenol Analysismentioning

confidence: 99%

Artemisia princeps Extract Promoted Glucose Uptake in Cultured L6 Muscle Cells via Glucose Transporter 4 Translocation

Yamamoto¹,

Ueda

Kawabata

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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“…Traditionally, the decoction of this herb has been used as health food and for the treatment of inflammation, carbuncle, diarrhea, and circulatory disorders and a hepatoprotective and antibacterial agent in Korea, China, and Japan (Jung et al, 2007). A. princeps extract have been reported to have anti-tumor promotion effects (Seo et al, 2002) and anti-cancer effects against several cancers via the induction of apoptosis (Cho et al, 2011;Sarath et al, 2007).…”

Section: Introductionmentioning

confidence: 96%

Chemopreventive effects of standardized ethanol extract from the aerial parts of Artemisia princeps Pampanini cv. Sajabal via NF-κB inactivation on colitis-associated colon tumorigenesis in mice

Chung

Choi

Shin³

et al. 2015

Food and Chemical Toxicology

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The anti-diabetic effects of ethanol extract from two variants of Artemisia princeps Pampanini in C57BL/KsJ-db/db mice

Cited by 70 publications

References 45 publications

Effects of Dietary Onion (<i>Allium cepa</i> L.) in a High-Fat Diet Streptozotocin-Induced Diabetes Rodent Model

Effects of Dietary Onion (<i>Allium cepa</i> L.) in a High-Fat Diet Streptozotocin-Induced Diabetes Rodent Model

Artemisia princeps Extract Promoted Glucose Uptake in Cultured L6 Muscle Cells via Glucose Transporter 4 Translocation

Chemopreventive effects of standardized ethanol extract from the aerial parts of Artemisia princeps Pampanini cv. Sajabal via NF-κB inactivation on colitis-associated colon tumorigenesis in mice

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