Chemopreventive effects of standardized ethanol extract from the aerial parts of Artemisia princeps Pampanini cv. Sajabal via NF-κB inactivation on colitis-associated colon tumorigenesis in mice

Chung, Kyung‐Sook; Choi, Hyun‐Chul; Shin, Ji‐Sun; Cho, Eu-Jin; Cho, Young-Wuk; Choi, Jung‐Hye; Baek, Nam‐In; Lee, Kyung‐Tae

doi:10.1016/j.fct.2014.11.007

Cited by 14 publications

(12 citation statements)

References 56 publications

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“…The genus Artemisia is a mostly perennial plant distributed in the northern hemisphere and is composed of approximately 250 species. They have a wide range of applications including uses in medicines, food, and spices [ 1 , 2 ]. Artemisia princeps (Japanese mugwort or yomogi ) is cultivated in East Asia and has been used in traditional Asian medicine for the treatment of inflammation, diarrhea, carbuncles, bacterial infection, and circulatory disorders [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…They have a wide range of applications including uses in medicines, food, and spices [ 1 , 2 ]. Artemisia princeps (Japanese mugwort or yomogi ) is cultivated in East Asia and has been used in traditional Asian medicine for the treatment of inflammation, diarrhea, carbuncles, bacterial infection, and circulatory disorders [ 1 , 2 ]. Many studies have demonstrated the anti-atherosclerotic, anti-oxidant, and anti-inflammatory effects of Artemisia princeps extract [ 1 , 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway

Hirano

Goto

Mitsui

et al. 2017

IJMS

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The Japanese mugwort, Artemisia princeps (yomogi in Japanese), has anti-inflammatory and antioxidant effects. Skin care products containing Artemisia princeps extract (APE) are known to improve dry skin symptoms in atopic dermatitis. Atopic dry skin is associated with a marked reduction of skin barrier proteins, such as filaggrin (FLG) and loricrin (LOR). Recently, aryl hydrocarbon receptor (AHR), and its downstream transcription factor OVO-like 1 (OVOL1), have been shown to regulate the gene expression of FLG and LOR. The focus of this paper is to evaluate the effects of APE on the AHR/OVOL1/FLG or LOR pathway since they have remained unknown to this point. We first demonstrated that non-cytotoxic concentrations of APE significantly upregulated antioxidant enzymes, NAD(P)H dehydrogenase quinone 1 and heme oxygenase 1, in human keratinocytes. Even at these low concentrations, APE induced nuclear translocation of AHR and significantly upregulated CYP1A1 (a specific target gene for AHR activation), FLG, and LOR expression. AHR knockdown downregulated OVOL1 expression. The APE-induced upregulation of FLG and LOR was canceled in keratinocytes with AHR or OVOL1 knockdown. In conclusion, antioxidant APE is a potent phytoextract that upregulates FLG and LOR expression in an AHR/OVOL1-dependent manner and this may underpin the barrier-repairing effects of APE in treating atopic dry skin.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway

Hirano

Goto

Mitsui

et al. 2017

IJMS

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“…A. princeps, Japanese mugwort, is a perennial and very vigorous plant known as yomogi in Japanese. Recently, the leaves of A. argyi and A. princeps and their components have been shown to have antitumour [5–8], antifungal [9], anticoagulant [10], antidiabetic [11], and anti-inflammatory [12, 13] activity.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effects ofArtemisiaLeaf Extract in Mice with Contact DermatitisIn VitroandIn Vivo

Yun

Jung

Chun

et al. 2016

Mediators of Inflammation

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The leaves of Artemisia argyi Lev. et Vant. and A. princeps Pamp. are well known medicinal herbs used to treat patients in China, Japan, and Korea with skin problems such as eczema and itching, as well as abdominal pain and dysmenorrhoea. We investigated the anti-inflammatory effects of Artemisia leaf extract (ALE) using CD mice and Raw 264.7 cells. The effects of ALE on histopathological changes and cytokine production in ear tissues were assessed in mice with CD induced by 1-fluoro-2,4-dinitrobenzene (DNFB). Moreover, the anti-inflammatory effects on production levels of prostaglandin E2 (PGE2) and nitric oxide (NO) and expression levels of cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) were investigated in Raw 264.7 cells. Topical application of ALE effectively prevented ear swelling induced by repeated DNFB application. ALE prevented epidermal hyperplasia and infiltration of immune cells and lowered the production of interferon- (IFN-) gamma (γ), tumour necrosis factor- (TNF-) alpha (α), and interleukin- (IL-) 6 in inflamed tissues. In addition, ALE inhibited expression of COX-2 and iNOS and production of NO and PGE2 in Raw 264.7 cells. These results indicate that Artemisia leaf can be used as a therapeutic agent for inflammatory skin diseases and that its anti-inflammatory effects are closely related to the inhibition of inflammatory mediator release from macrophages and inflammatory cytokine production in inflamed tissues.

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“…The tablet was added to the dissolution medium (900 mL of acidic buffer solution at pH 1.2 supplemented with 0.5 % SLS) without a sinker and rotated at a speed of 50 rpm at 37.0 ± 0.2 °C (n =12). Samples were collected at specific time intervals (5,10,15,30,45, and 60 min) to analyze the amount of eupatilin using HPLC.…”

Section: Dissolution Rate Of Tablets At Ph 12 (Determination Of Disimentioning

confidence: 99%

“…Therefore, the isopropanol extract of A. princeps is expected to have more potent pharmacological actions and fewer toxic or unwanted side effects. Although various biological activities of A. princeps have been demonstrated, including anti-cancer, immunomodulatory, anti-oxidant, anti-diabetic and antiatherosclerotic activities (15,16), no report has been published on gastroprotective or anti-ulcer activities of isopropanol extracts from the aerial parts of A. princeps (IPAP). In this study, we investigated the gastroprotective potential of IPAP in rats with ethanol and HCl or indomethacin-induced gastric ulcer with or without pylorus ligation.…”

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confidence: 99%

Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury

et al. 2017

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In this study, we investigated the gastroprotective effect of an isopropanol extract from the aerial parts of Artemisia princeps (IPAP) and developed a gastroretentive floating tablet of IPAP (IPAP-FR) for maximized local gastroprotective effects. Pre-treatment with IPAP ameliorated the gastric mucosal hemorrhagic lesions in ethanol/HCl-or indomethacin-treated rats. IPAP decreased mucosal hemorrhage of gastric ulcers induced by ethanol or indomethacin plus pyloric ligation in rats. The optimized floating tablet, IPAP-FR, floated on medium surface with more sustained eupatilin release compared to the non-floating control tablet. X-ray photographs in beagle dogs showed that IPAP-FR was retained for > 2 h in the stomach. In the ethanol-induced gastric ulcer rat model, the gastric hemorrhagic lesion was improved more substantially with IPAP-FR compared to the non-floating control tablet. Based on these data, our data suggest that IPAP-FR has an improved therapeutic potential for the treatment of gastric ulcer.

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Chemopreventive effects of standardized ethanol extract from the aerial parts of Artemisia princeps Pampanini cv. Sajabal via NF-κB inactivation on colitis-associated colon tumorigenesis in mice

Cited by 14 publications

References 56 publications

Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway

Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway

Anti-Inflammatory Effects ofArtemisiaLeaf Extract in Mice with Contact DermatitisIn VitroandIn Vivo

Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury

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