Abstract:Regional cerebral blood flow, an index of local neuronal activity, was measured using positron emission tomography (PET) during the performance of the classic Stroop color/word task in eight healthy right-handed subjects.In the first condition of this paradigm, subjects name the color of the words presented on a video monitor. All the words are the color names congruent to the color presented (e.g., the noun "red" displayed in red color). In the second condition, subjects also name the color of the words prese… Show more
“…Different aspects of inhibitory control may be distinguished [56], especially those preventing access to goal-irrelevant information that may be partially activated, restraining access to strong but situationally inappropriate responses, and suppressing the activation of no longer relevant information. Most of the studies exploring inhibition processes have used different variants of the Stroop paradigm and showed increased activity during the interference condition (i.e., naming the font colour of letters that spell a colour word different than the colour-to-be-named) in the anterior cingulate gyrus and right orbitofrontal regions [15,70,91]. Moreover, increased activity has also been found in left inferior frontal regions [25,54,118] and in temporal and parietal areas [e.g., 25,118].…”
“…Different aspects of inhibitory control may be distinguished [56], especially those preventing access to goal-irrelevant information that may be partially activated, restraining access to strong but situationally inappropriate responses, and suppressing the activation of no longer relevant information. Most of the studies exploring inhibition processes have used different variants of the Stroop paradigm and showed increased activity during the interference condition (i.e., naming the font colour of letters that spell a colour word different than the colour-to-be-named) in the anterior cingulate gyrus and right orbitofrontal regions [15,70,91]. Moreover, increased activity has also been found in left inferior frontal regions [25,54,118] and in temporal and parietal areas [e.g., 25,118].…”
“…Converging evidence from PET and fMRI studies [41][42][43] have implicated this more dorsal/posterior region of the anterior cingulate, adjacent to the frontal limbic area, as playing a pivotal role in effortful attentional processes and conflict monitoring. These earlier findings are consistent with our hypothesis that effortful processing is reduced during the retrieval of positive words following reboxetine treatment.…”
Section: Reboxetine and Subsequent Recognitionmentioning
Recent neuropsychological studies in healthy volunteers suggest that antidepressants enhance the processing of positive emotional information. However, the neural substrates underpinning these changes have not been fully elucidated. The current study, therefore, used functional magnetic resonance imaging (fMRI) to map brain systems activated during successful categorization and subsequent recognition of self-referent positive and negative personality characteristics in healthy volunteers following short-term (7 days) repeated administration of the selective noradrenergic reuptake inhibitor reboxetine. Twenty-four healthy volunteers were randomly assigned to 7-day double-blind intervention with reboxetine or placebo. On day 7, neural responses during the categorization and subsequent recognition of positive and negative characteristics were assessed using fMRI. Questionnaires monitoring mood, hostility and anxiety were given before and during this intervention. During categorization, reboxetine was associated with greater activation to positive words, relative to negative words, in left precuneus and right inferior frontal gyrus. By contrast, at subsequent recognition reboxetine was associated with reduced response to positive words, relative to negative words, in left precuneus, anterior cingulate and medial frontal gyrus. These changes in the neural processing of positive and negative words occurred in the absence of significant differences in ratings of mood and anxiety. Such adaptations in the neural processing of emotional information support the hypothesis that antidepressants have early effects on emotional processing in a manner which would be expected to reverse negative biases in depression.
“…Based on these FMRI findings, it appears that a deficit in the neural circuitry for word fluency emerges with childhood-onset SLE, suggesting that FMRI may be sensitive in detecting early influences of childhood-onset SLE on the neural substrates of semantic association and other language functions. A variety of tests have been developed to measure attention (57,58). The CPT-IP task used in this study was designed to measure attention by requiring focus on a continuous stream of data while responding to specific stimuli, in accordance with a set of a priori instructions (59)(60)(61).…”
Section: Fmri In Childhood-onset Sle 4159mentioning
Objective. To investigate changes in brain activation patterns detected by functional magnetic resonance imaging (FMRI), and the relationship between FMRI activation patterns and results of formal neuropsychological testing, in patients with childhood-onset systemic lupus erythematosus (SLE).Methods. Ten patients with childhood-onset SLE underwent formal neuropsychological testing and FMRI using 3 paradigms: a continuous performance task (CPT) to evaluate attention, an N-Back task to assess working memory, and verb generation to evaluate language processing. Composite Z maps were generated to summarize the brain activation patterns for each FMRI paradigm in patients with childhood-onset SLE and to compare these patterns with those observed in healthy controls. Between-group comparison Z maps showing differences in activation between childhood-onset SLE patients and controls were generated, using a significance level of P < 0.05 in a general linear model.Results. Compared with the control group, the childhood-onset SLE group showed statistically significant increased activation of brain areas involved in the CPT, N-Back, and verb generation tasks. In contrast, in the absence of active stimulus, e.g., during times of the paradigm control tasks, childhood-onset SLE patients consistently undersuppressed activity in the expected brain areas. Activation in selected cortical areas was found to correlate negatively with results of a subset of individual neuropsychological test scores.Conclusion. FMRI abnormalities are present in childhood-onset SLE, manifesting as an imbalance between active and inhibitory responses to an array of stimuli. Differences in brain activation patterns compared with those observed in controls suggest that childhood-onset SLE may be associated with abnormalities in white matter connectivity resulting in neuronal network dysfunction, rather than injury of specific gray matter areas.Childhood-onset systemic lupus erythematosus (SLE) is among the most severe pediatric rheumatic diseases ("pediatric" defined as onset prior to age 16). Often diagnosed in US females of minority populations, SLE is associated with significant morbidity and at least 10 times higher mortality than that of the age-matched general population (1). The reported prevalence of neuropsychiatric involvement in SLE (NPSLE) varies between 15% and 95% (2,3), and children with SLE tend to exhibit a more severe phenotype than adults (4).
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