Brain imaging of the central executive component of working memory

Collette, Fabienne; Linden, Martial Van der

doi:10.1016/s0149-7634(01)00063-x

Cited by 498 publications

(325 citation statements)

References 118 publications

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“…Combining these findings with the evidence of lateral prefrontal cortexTs involvement in other cognitive switching tasks (e.g., Dove et al, 2000;Kimberg et al, 2000;Sohn et al, 2000) and in executive control in general (Collette and Linden, 2002;Funahashi, 2001;Osaka et al, 2004;Smith and Jonides, 1999), it seems that language switching involves inhibitory control function located in the lateral prefrontal cortex.…”

Section: Introductionmentioning

confidence: 63%

Neural bases of asymmetric language switching in second-language learners: An ER-fMRI study

et al. 2007

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Using the ER-fMRI technique, the present study was designed to investigate the neural substrates of language switching among secondlanguage learners. Twelve Chinese college students who were learning English were scanned when they performed language switching tasks (naming pictures in their first [L1, Chinese] and second [L2, English] languages according to response cues). Compared to non-switching conditions, language switching elicited greater activation in the right superior prefrontal cortex (BA9/10/32), left middle and superior frontal cortex (BA8/9/46), and right middle cingulum and caudate (BA11). When the direction of switching was considered, forward switching (from L1 to L2), but not backward switching (from L2 to L1), activated several brain regions related to executive functions (i.e., bilateral frontal cortices and left ACC) relative to non-switching conditions. These results suggest that neural correlates of language switching differ depending on the direction of the switch and that there does not seem to be a specific brain area acting as a "language switch".

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Section: Introductionmentioning

confidence: 63%

Neural bases of asymmetric language switching in second-language learners: An ER-fMRI study

et al. 2007

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“…Previous studies have demonstrated that the performance of various executive tasks (such as manipulation of information, inhibition, shifting, and updating) is associated with increased cerebral activity in both prefrontal and parietal areas (for a review, see [13]). These results suggest that executive functioning is based on a network of anterior and posterior cerebral areas and is not subserved by the frontal lobes alone.…”

Section: Discussionmentioning

confidence: 99%

Involvement of both prefrontal and inferior parietal cortex in dual-task performance

Collette

Olivier

Linden

et al. 2005

Cognitive Brain Research

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135

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This PET study explored the neural substrate of both dual-task management and integration task using single tasks that are known not to evoke any prefrontal activation. The paradigm included two simple (visual and auditory) discrimination tasks, a dual task and an integration task (requiring simultaneous visual and auditory discrimination), and baseline tasks (passive viewing and hearing). Data were analyzed using SPM99. As predicted, the comparison of each single task to the baseline task showed no activity in prefrontal areas. The comparison of the dual task to the single tasks demonstrated left-sided foci of activity in the frontal gyrus (BA 9/46, BA 10/47 and BA 6), inferior parietal gyrus (BA 40), and cerebellum. By reference to previous neuroimaging studies, BA 9/46 was associated with the coordinated manipulation of simultaneously presented information, BA 10/47 with selection processes, BA 6 with articulatory rehearsal, and BA 40 with attentional shifting. Globally similar regions were found for the integration task, except that the inferior parietal gyrus was not recruited. These results confirm the hypothesis that the left prefrontal cortex is implicated in dual-task performance. Moreover, the involvement of a parietal area in the dual task is in keeping with the hypothesis that a parieto-frontal network sustains executive functioning. Theme: Neural basis of behaviorTopic: Cognition

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“…Among the executive functions, inhibition has been recognized as an essential system (e.g. Collette and Van der Linden 2002). A hypothesis that has attracted increasing attention suggests that alcoholism is a 'disinhibitory disorder'.…”

Section: Introductionmentioning

confidence: 99%

Alcohol cues increase cognitive impulsivity in individuals with alcoholism

et al. 2007

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Background Individuals with alcoholism are characterized by both attentional bias for alcohol cues and prepotent response inhibition deficit. We tested the hypothesis that alcoholics exhibit greater cognitive disinhibition when the response to be suppressed is associated with alcohol-related information. Methods Forty recently detoxified individuals with alcoholism were compared with 40 healthy non-substance abusers on the "Alcohol-Shifting Task", a variant of the go/no-go paradigm requiring a motor response to targets and no response to distracters. The aim was to test the ability of alcoholics to discriminate between alcohol-related and neutral words. Sometimes, the alcohol-related words were the targets for the "go" response, with neutral words as distracters, sometimes the reverse. Several shifts in target type occurred during the task. Results Alcoholics made significantly more commission errors (i.e., press a key when a distracter displayed) and more omission errors (i.e., not press a key when a target displayed) than controls. Moreover, the number of commission errors was greater in alcoholics when alcoholrelated stimuli had to be detected. Conclusions These results demonstrate that alcoholics exhibit a basic prepotent response inhibition deficit, which is enhanced when the response to be suppressed is related to alcohol. We discuss clinical and theoretical implications of these findings.

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Brain imaging of the central executive component of working memory

Cited by 498 publications

References 118 publications

Neural bases of asymmetric language switching in second-language learners: An ER-fMRI study

Neural bases of asymmetric language switching in second-language learners: An ER-fMRI study

Involvement of both prefrontal and inferior parietal cortex in dual-task performance

Alcohol cues increase cognitive impulsivity in individuals with alcoholism

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