The fact theat all ordinary Illeal induces (definite Two criteria were used for differentiation bet\-een a normal and abnormal response of the electrocardiogram to a meal: the response wras considered to be abnormal (1) when, according to accepted standards,14 it was normal or borderline before the meal but abnormal after the meal;(2) when the changes exceeded the expectancy range for 98 per cent of the normal population.13In normal subjects it was found that the changes of CF4 or V4 were very similar,"3 so that the normal standards for V4 may also be applied for CF4.Patients. All patients were ambulatory and in a state of apparent compensation at the time of the test. Most of them were between 40 and 60 years of age. About half of the patients (45) were members of a large experimental group of 500 subjects presently under study of this Laboratory l5 In 29 patients, the electrocardiograms were the only abnormal (or borderline) findings of a thorough physiologic and clinical examination. Thus, the majority of our patients were in an incipient phase of cardiovascular degeneration, except a group of 23 patients with diagnosed corona'y insufficiency,.The patients were grouped into six major categories: (I) Suspected coronary insufficiency (16 pa-