We thank Unlu et al 1 and Altun and Cintosun 2 for their interest in our study entitled ''The Ankle-Brachial Index Is Associated With Cardiovascular Complications After Noncardiac Surgery.'' 3 Altun and Cintosun 2 argue that pulse wave velocity (PWV) and ankle-brachial index (ABI) are markers of cardiovascular (CV) disease and that PWV is considered the gold standard for the measurement of arterial stiffness (AS). 4 They suggest that measuring PWV could have been useful in our study. 3 We agree that the relationship between AS (assessed by PWV) and postoperative CV complications should be investigated. However, in our study, we used the ABI as a marker of lower extremity peripheral arterial disease (PAD) and not as a marker of AS. Although PAD and AS may coexist, they are distinct and may not be present simultaneously (eg, a patient with an ABI > 1.4 may have AS but not always occlusive disease).Several studies have assessed the relationship of troponin elevation and CV complications after surgery. The Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) trial and other studies, including 2 meta-analyses, have shown that isolated troponin elevation after surgery is associated with a worse prognosis in short-term and longterm follow-up. [5][6][7][8][9] The higher the troponin value, the worse the prognosis.In our study, preoperative serum creatinine (2.1 + 2.4 mg/dL vs 1.0 + 0.4 mg/dL, P ¼ .001), abnormal ABI (47.4% vs 20.0%, P ¼ .018), duration of anesthesia (444 + 184 minutes vs 372, + 176 minutes, P ¼ .041), and hemodynamic instability (46.0% vs 14.1%, P ¼ .001) were all associated with elevated levels of troponin. After logistic regression, an abnormal ABI (odds ratio [OR]: 13.4, 95% confidence interval [