The ANKK1 Gene Associated with Addictions Is Expressed in Astroglial Cells and Upregulated by Apomorphine

Hoenicka, Janet; Quiñones-Lombraña, Adolfo; España‐Serrano, Laura; Alvira‐Botero, Ximena; Kremer, Leonor; Pérez‐González, Rocío; Rodríguez‐Jiménez, Roberto; Jiménez‐Arriero, Miguel Ángel; Ponce, G.; Palomo, Tomás

doi:10.1016/j.biopsych.2009.08.012

Cited by 60 publications

(88 citation statements)

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“…The A1 allele is linked with not only substance abuse disorders, in particular, alcohol (Gelernter et al 1999;Munafo et al 2007;Smith et al 2008;Yang et al 2008;Ridge and Dodd 2009), but also with impulsiveness (White et al 2009) and components of working memory (Stelzel et al 2009); the TaqIA SNP has been linked to addiction (Xu et al 2004), psychosis (Wu et al 2006;Ponce et al 2009;Shen et al 2009), extraverted personality (Smillie et al 2010), and antisocial personality (Ponce et al 2003;Hoenicka et al 2007). According to Hoenicka et al (2010), TaqIA is located in the coding region of the ANKK1 gene that overlaps DRD2 and encodes a predicted kinase ANKK1. These cited authors demonstrated that the ANKK1 mRNA and protein were expressed in the astrocytes of the adult CNS in humans and rodents, observing that ANKK1 mRNA levels in mouse astrocytes cultures were upregulated by apomorphine, thereby implicating DA.…”

Section: Genetic Influences In Brain Disordersmentioning

confidence: 99%

Epigenetics and Biomarkers in the Staging of Neuropsychiatric Disorders

et al. 2010

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Epigenetics, or alterations in the phenotype or gene expression due to mechanisms other than changes in the underlying DNA sequence, reflects the sensitivity and responsiveness of human and animal brains in constantly varying circumstances regulating gene expression profiles that define the biomarkers and present the ultimate phenotypical outcomes, such as cognition and emotion. Epigenetics is associated with functionally relevant alterations to the genome in such a fashion that under the particular conditions of early, adolescent, and adult life, environmental signals may activate intracellular pathways that remodel the "epigenome," triggering changes in gene expression and neural function. Thus, genetic influences in neuropsychiatric disorders that are subject to clinical staging, epigenetics in schizophrenia, epigenetic considerations in the expression of sensorimotor gating resulting from disease conditions, biomarkers of drug use and addiction, current notions on the role of dopamine in schizophrenia spectrum disorders, and the discrete interactions of biomarkers in persistent memory were to greater or lesser extents reflected upon. The relative contributions of endophenotypes and epistasis for mediating epigenetic phenomena and the outcomes as observed in the analysis of biomarkers appear to offer a multitude of interactive combinations to further complicate the labyrinthine machinations of diagnosis, intervention, and prognosis.

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Section: Genetic Influences In Brain Disordersmentioning

confidence: 99%

Epigenetics and Biomarkers in the Staging of Neuropsychiatric Disorders

et al. 2010

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“…This single-nucleotide polymorphism is, however, actually located 10 kB downstream of DRD2 in a neighboring gene called ankyrin-containing kinase 1 (ANKK1). A potential association of ANKK1 with dopaminergic neurotransmission has been explained as an upregulation of ANKK1 mRNA in mural astroglial cells caused by apomorphine [30]. The mutated A1 allele has a prevalence of 28% in the healthy Caucasian population; the prevalence of homozygotic A1 allele carriers is 3% [23].…”

Section: Introductionmentioning

confidence: 99%

Specific Reaction Patterns to Distinct Positive Emotional Cues Related to Incentive Motivation in Dependence of the Taq1A-Polymorphism: Molecular Genetic Associations of Early and Late Event-Related Potentials

Munk

Wielpuetz²,

Osinsky³

et al. 2016

Neuropsychobiology

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Background/Aims: Early and late event-related potential (ERP) responses, representing early subconscious and late motivational processes, were recorded for positive emotional words related to ‘wanting' and ‘liking', in dependence of the dopamine-related Taq1A genotype (ANKK1/DRD2). Research suggests that ‘wanting' as opposed to ‘liking' is related to dopaminergic processes. Therefore, it was hypothesized that risk allele carriers of the Taq1A polymorphism exhibit late ERP changes in reaction to words representing incentive motivation, i.e. ‘wanting' (word categories ‘lust' and ‘anticipation'), but not to words representing ‘liking' (‘closeness'). Methods: Seventy-two male participants performed an emotional-word Stroop task during EEG recording and were genotyped according to the Taq1A polymorphism of ANKK1/DRD2. Results: Positive emotional words related to anticipation and lust revealed blunted responses in the late positive potential (LPP) in carriers of the A1 allele, an effect absent in response to ‘liking'-related words. These differences were not evident in the earlier posterior negativity (EPN). Conclusion: As no differences in dependence of the Taq1A genotype were observed in reaction to ‘wanting'- and ‘liking'-related words in the EPN, but merely in the LPP, it can be assumed that incentive-motivational stimuli only modify motivation-related ERP responses in carriers of the A1 allele of the Taq1A polymorphism, indicating the role of dopamine in late ERP components.

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“…2010). Here, since ANKK1 and DRD2 are overlapping genes at their 3′ untranslated regions (3′ UTR) (Hoenicka et al.…”

Section: Resultsmentioning

confidence: 99%

“…The ANKK1 gene encodes a putative kinase of unknown function which might also be connected with dopaminergic system functioning (Hoenicka et al. 2010; Garrido et al. 2011).…”

Section: Introductionmentioning

confidence: 99%

The ANKK1/DRD2 locus is a genomic substrate for affective priming and recognition of angry faces

et al. 2015

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IntroductionAnkyrin repeat and kinase domain containing I (ANKK1) and dopamine D2 receptor (DRD2) genes have been associated with psychopathic traits in clinical samples. On the other hand, individuals high in psychopathy show reduced affective priming and deficits in facial expression recognition. We have hypothesized that these emotion‐related cognitive phenomena are associated with Taq IA (rs18000497) SNP (single nucleotide polymorphism) of the ANKK1 gene and with C957T (rs6277) SNP of the DRD2 gene.MethodsWe performed a genetic association analysis in 94 self‐reported Caucasian healthy volunteers. The participants completed 144 trials of an affective priming task, in which primes and targets were emotional words. They also had to recognize 64 facial expressions of happiness, sadness, anger, and fear in an expression recognition task. Regarding the genetic analyses, Taq IA and C957T SNPs were genotyped.ResultsWe found that the C957T SNP TT genotype was associated with a stronger priming effect and a better recognition of angry expressions. No associations were found for the Taq IA SNP. In addition, in silico analysis demonstrated that C957T SNP is a marker of a regulatory sequence at the 5′ UTR of ANKK1 gene, thus suggesting the involvement of the whole ANKK1/DRD2 locus in cognitive–emotional processing.ConclusionsThese results suggest that affective priming and recognition of angry facial expressions are endophenotypes that lie on the pathway between the ANKK1/DRD2 locus and some deviant phenotypes.

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The ANKK1 Gene Associated with Addictions Is Expressed in Astroglial Cells and Upregulated by Apomorphine

Cited by 60 publications

References 43 publications

Epigenetics and Biomarkers in the Staging of Neuropsychiatric Disorders

Epigenetics and Biomarkers in the Staging of Neuropsychiatric Disorders

Specific Reaction Patterns to Distinct Positive Emotional Cues Related to Incentive Motivation in Dependence of the Taq1A-Polymorphism: Molecular Genetic Associations of Early and Late Event-Related Potentials

The ANKK1/DRD2 locus is a genomic substrate for affective priming and recognition of angry faces

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