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502LETTERS TO THE EDITOR for a 7 ray of energy (990±30) Mev. The error is statistical. We estimate systematic errors to be about 30% primarily arising from uncertainty about the bremsstrahlung spectrum close to the upper end. The beam integration was carried out using a total absorption ion chamber. 2 Measurements of the photoproduction of K mesons by 1-Bev 7 rays have been reported previously by Donoho and Walker at the California Institute of Technology. 3 Their measurements together with ours are plotted in Fig. 2. The curves drawn are from calculations by Fujii and Marshak. 4 The curve labeled S' is calculated for a scalar K meson and the one labeled PS' is for a pseudoscalar K meson. An anomalous magnetic moment of 1.793 nm is taken for the proton and 1.212 nm for the A 0 in both cases. The form of the curve for scalar K mesons is typical of photoelectric production (retarded sin 2 0) and seems to be rather insensitive to the detailed assumptions of the theory. The PS' curve depends critically on the assumption of the theory, particularly the sign and magnitude of the anomalous moment of the A 0 . The absolute values of the cross sections determine the coupling constant GNKA 2 /^ which is otherwise arbitrary in the theory. The results are consistent with a scalar K meson with a coupling constant 6W#A 2 /47T=3:±:1. This is a rather large coupling constant. It should be emphasized that the above statement is meant to indicate a trend and should not be taken as strong evidence against pseudoscalar K mesons. 5 Because of the sensitivity of the calculations to the precise choice of anomalous moment, the present experimental data are insufficient to allow a reliable choice between the scalar and pseudoscalar 0.4 0.3h .0 0.2 h L.-\*^ 1 > ^ < k Cornell Point 6 C.I.T. Points ' \ "f / V 30° 60° 90° 0cm. 120° 150° 180° FIG. 2. Plot of the measured differential cross sections from this experiment and that of Donoho and Walker. The curves labeled PS' and S' are taken from the calculations of Fujii and Marshak. The assumptions under which the calculations were made are discussed in the text.theories to be made. This decision must await more complete information about the angular distribution, particularly at forward angles.T HE recent demonstration 1 that parity conservation, charge-conjugation invariance, and perhaps time-reversal (TR) invariance do not hold in weak interactions should cause physicists to re-examine the foundations of their beliefs that strong interactions are invariant with respect to these symmetries. Lee and Yang 2 summarize some of the older evidence for believing in the parity conservation of strong interactions; their conclusions have been considerably strengthened by recent experiments, 3 which indicate that states with opposite parity are not mixed by nuclear forces with amplitudes as large as 10~3 to 10~~4.We have accepted the evidence for parity conservation in strong interactions as amply convincing, and have examined in some detail TR invariance in nuclear interactions. One conclusion of thi...
502LETTERS TO THE EDITOR for a 7 ray of energy (990±30) Mev. The error is statistical. We estimate systematic errors to be about 30% primarily arising from uncertainty about the bremsstrahlung spectrum close to the upper end. The beam integration was carried out using a total absorption ion chamber. 2 Measurements of the photoproduction of K mesons by 1-Bev 7 rays have been reported previously by Donoho and Walker at the California Institute of Technology. 3 Their measurements together with ours are plotted in Fig. 2. The curves drawn are from calculations by Fujii and Marshak. 4 The curve labeled S' is calculated for a scalar K meson and the one labeled PS' is for a pseudoscalar K meson. An anomalous magnetic moment of 1.793 nm is taken for the proton and 1.212 nm for the A 0 in both cases. The form of the curve for scalar K mesons is typical of photoelectric production (retarded sin 2 0) and seems to be rather insensitive to the detailed assumptions of the theory. The PS' curve depends critically on the assumption of the theory, particularly the sign and magnitude of the anomalous moment of the A 0 . The absolute values of the cross sections determine the coupling constant GNKA 2 /^ which is otherwise arbitrary in the theory. The results are consistent with a scalar K meson with a coupling constant 6W#A 2 /47T=3:±:1. This is a rather large coupling constant. It should be emphasized that the above statement is meant to indicate a trend and should not be taken as strong evidence against pseudoscalar K mesons. 5 Because of the sensitivity of the calculations to the precise choice of anomalous moment, the present experimental data are insufficient to allow a reliable choice between the scalar and pseudoscalar 0.4 0.3h .0 0.2 h L.-\*^ 1 > ^ < k Cornell Point 6 C.I.T. Points ' \ "f / V 30° 60° 90° 0cm. 120° 150° 180° FIG. 2. Plot of the measured differential cross sections from this experiment and that of Donoho and Walker. The curves labeled PS' and S' are taken from the calculations of Fujii and Marshak. The assumptions under which the calculations were made are discussed in the text.theories to be made. This decision must await more complete information about the angular distribution, particularly at forward angles.T HE recent demonstration 1 that parity conservation, charge-conjugation invariance, and perhaps time-reversal (TR) invariance do not hold in weak interactions should cause physicists to re-examine the foundations of their beliefs that strong interactions are invariant with respect to these symmetries. Lee and Yang 2 summarize some of the older evidence for believing in the parity conservation of strong interactions; their conclusions have been considerably strengthened by recent experiments, 3 which indicate that states with opposite parity are not mixed by nuclear forces with amplitudes as large as 10~3 to 10~~4.We have accepted the evidence for parity conservation in strong interactions as amply convincing, and have examined in some detail TR invariance in nuclear interactions. One conclusion of thi...
supplemental data, there are expanded opportunities for researchers to disseminate actual study data; this should facilitate independent evaluation by regulatory agencies. As scientists specializing in regulatory safety evaluations, we have extensive experience in interpreting chemical toxicity studies from government, academia, and private-sector laboratories. In conducting chemical risk assessments, we believe that scientists from all sectors should support the use of objective criteria for determining data quality and study reliability (Schneider et al. 2009) coupled with a structured evaluative framework, such as that of the World Health Organization International Programme on Chemical Safety (Boobis et al. 2006, 2008), to provide a systematic approach for assessing the overall weight of the evidence for observed effects and the postulated mode of action. In this manner, data from laboratory experiments, epidemiological investigations, and cutting-edge mecha-nistic research from all relevant studies-GLP and non-GLP-and from all investigators, regardless of affiliation or funding source, can be comprehensively reviewed, given appropriate weight, and integrated in a manner that provides a robust, biologically plausible understanding of the potential hazards and risks that exposures to a substance could pose. This letter has been reviewed in accordance with the peer-and administrative-review poli cies of the authors' organizations. The views expressed here are those of the authors and do not necessarily reflect the opinions and/or policies of their employers. The authors are employed by trade associa tions whose members manufacture and use chemicals.
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