The angiotensin II receptors type 1 blockage affects the urinary bladder activity in hyperosmolar-induced detrusor overactivity in rats: Preliminary results

Abstract

Background. Angiotensin II receptors play a role in the pathogenesis of urinary bladder dysfunction, especially in the case of bladder outlet obstruction. The function of these receptors in the detrusor overactivity (DO) still remains unclear.

Comparative effects of angiotensin II on the contractility of muscularis mucosae and detrusor in the pig urinary bladder

“…The DSM has been shown to possess enzymes that generate ATII, and receptors for this peptide which when activated induce contractile responses. 12,[16][17][18][19] Angiotensin receptors have been identified on the arteries in the submucosa, but our study show that ATR1 are also present in the mucosa on the MM. Furthermore, the receptors are functional, increasing basal tonic tension and accelerating phasic contractile activity.…”

“…Whether local ATII synthesis within the bladder is altered in conditions, such as OAB is currently unclear. However, angiotensin receptor blockers and ACE inhibitors have been shown to reduce bladder dysfunction in several animal models of bladder overactivity 18,23 . Since the contractility of MM is enhanced by pM range of ATII, MM can readily sense circadian rhythms of RAS or its upregulation in pathological conditions.…”

“…However, angiotensin receptor blockers and ACE inhibitors have been shown to reduce bladder dysfunction in several animal models of bladder overactivity. 18,23 Since the contractility of MM is enhanced by pM range of ATII, MM can readily sense circadian rhythms of RAS or its upregulation in pathological conditions. Thus, MM appears to play an important role in normal bladder function and in bladder pathology in association with RAS.…”

“…The results from our functional antagonist study suggest that the responses of the porcine MM to ATII are mediated via the ATR1 subtype. This receptor has been previously identified in the DSM of the rat, rabbit and human bladder, 11,15,18,19 but its effect has never previously been examined in the MM. Our results show that the greatest responses to ATII occur in the MM and not the detrusor, with MM contractions being 10-fold greater than DSM responses.…”

Unveiling the Angiotensin-(1–7) Actions on the Urinary Bladder in Female Rats

“…The regulation of UB function is dependent on the autonomic and somatic nervous systems. Cholinergic (via muscarinic receptors) and adrenergic (via α and β receptors) transmissions, as well as noncholinergic/nonadrenergic mechanisms (NCNA), exert an important function in the storage of urine and voiding ( Juszczak and Maciukiewicz, 2017 ). Several neurotransmitters of the NCNA branch of the autonomic nervous system, for instance, ATP, substance P, and neuropeptide Y, can play stimulatory or inhibitory neuromodulation of cholinergic, adrenergic, or purinergic transmission in the lower urinary tract ( Hoyle, 1994 ; Juszczak and Maciukiewicz, 2017 ).…”